Biochemical findings Flashcards
In which condition would the following biochemical findings be present?
- High IGF-1
- Failure to suppress GH following administration of 75g of glucose (oral glucose tolerance test)
Acromegaly
In which condition would the following biochemical findings be present?
- Raised Urea
- Raised Creatinine
- Raised K+
- Metabolic acidosis
Acute Kidney Injury
In which condition would the following biochemical findings be present?
- High amylase
- Other findings may be present, dependent upon cause
Acute pancreatitis
In which condition would the following biochemical findings be present?
- High Bilirubin
- High ALP
- High GGT
- (ALT and AST may also be raised)
Cholestasis
In which condition would the following biochemical findings be present?
- High urea
- High creatinine
- High potassium
- Low calcium (and low 1,25 dihydroxy vit. D)
- High phosphate
- Anaemia
- Metabolic acidosis
Chronic Kidney Disease
In which condition would the following biochemical findings be present?
- Low Potassium
- Metabolic alkalosis
- High urine potassium
- High aldosterone
- Low renin
Conn’s syndrome
In which condition would the following biochemical findings be present?
- High 24hr urine cortisol
- Failure to suppress ACTH during overnight dexamethasone test
Cushing’s syndrome
In which condition would the following biochemical findings be present?
- High sodium
- High urea
- High plasma osmolality
- Low urine osmolality
Diabetes insipidus
In which condition would the following biochemical findings be present?
- High glucose
- High ketones
- Metabolic acidosis (with raised anion gap)
Diabetic ketoacidosis
In which condition would the following biochemical findings be present?
- High total cholesterol
- High LDL
Familial hypercholesterolaemia
In which condition would the following biochemical findings be present?
- High calcium
- High or normal PTH
- Low 24h urine calcium
Familial hypocalciuric hypercalcaemia
In which condition would the following biochemical findings be present?
- High bilirubin
- Defect found in UTG1A1 gene (UDP-glucuronosyltransferase 1A1)
Gilbert’s Syndrome
In which condition would the following biochemical findings be present?
- Failure to show increase in growth hormone following insulin tolerance test
Growth hormone deficiency
In which condition would the following biochemical findings be present?
- High ALT
- High AST
- Bilirubin, ALP and GGT may also be raised
Hepatitis
In which condition would the following biochemical findings be present?
- Respiratory alkalosis
Hyperventilation
In which condition would the following biochemical findings be present?
- Low calcium
- High phosphate
- Low PTH
Hypoparathyroidism
In which condition would the following biochemical findings be present?
- Low glucose
- High insulin
- High C-peptide
Insulinoma
In which condition would the following biochemical findings be present?
- High calcium
- Low PTH
Malignant hypercalcaemia
In which condition would the following biochemical findings be present?
- Metabolic acidosis (raised anion gap)
- High osmolar gap
Methanol overdose
In which condition would the following biochemical findings be present?
- High troponin
- High CK
Myocardial infraction
In which condition would the following biochemical findings be present?
- Low albumin
- Low sodium
- High 24h urine protein
Nephrotic syndrome
In which condition would the following biochemical findings be present?
- High ALP
Paget’s disease
In which condition would the following biochemical findings be present?
- High 24h urine metadrenalines
Consider investigation for Multiple Endocrine Neoplasia type II
Phaechromocytoma
In which condition would the following biochemical findings be present?
- Cholestatic LFTs (high bilirubin, ALP, GGT and possibly ALT and AST)
- Positive Anti-microbial antibodies
Primary Biliary Cirrhosis
In which condition would the following biochemical findings be present?
- High calcium
- Low phosphate
- Inappropriately high PTH
Consider investigations for Multiple Endocrine Neoplasia
Primary Hyperparathyroidism
In which condition would the following biochemical findings be present?
- Low T4
- Low T3
- High TSH
Primary hypothyroidism
In which condition would the following biochemical findings be present?
- Low sodium
- Normal Plasma osmolality
Pseudohyponatraemia
In which condition would the following biochemical findings be present?
- Low phosphate
- Low potassium
- Low magnesium
Refeeding syndrome
In which condition would the following biochemical findings be present?
- Metabolic acidosis (with normal anion gap)
Renal tubular acidosis
In which condition would the following biochemical findings be present?
- Low T4
- Low T3
- Low (or low normal TSH)
Secondary hypothyroidism
In which condition would the following biochemical findings be present?
- Low sodium
- Low plasma osmolality
- High urine osmolality
- Urine sodium > 20mmol/L
SIADH
In which condition would the following biochemical findings be present?
- High T4
- High T3
- Low TSH
Thyroid antibodies may be positivie, depending upon cause
Thyrotoxicosis
In which condition would the following biochemical findings be present?
- High Glucose
- High Ketones (in DKA)
- Positive anti-GAD antibodies
- Positive islet cell antibodies
Type I Diabetes
In which condition would the following biochemical findings be present?
- Low calcium
- Low phosphate
- High ALP
Vitamin D deficiency
