The heart Flashcards
Mention the parts of the heart.
What are the 3 types of cardiac muscle that compose the heart and what type of muscle is the cardiac muscle?
Cardiac muscle is striated. The 3 major typer of cardiac muscle are: atrial muscle, ventricular muscle, and specialized excitatory and conductive muscle fibers.
Whta type of myofibrils are found in the cardiac muscle?
Actin and myosin
Why is the heart considered a synccytium and what are the 2 syncytiums it is composed of?
It is a syncytium because the many cardiac cells are so interconnected that when one cell becomes excited, the action potential rapidly spreads to all of them.
The heart is composed of two syncytiums: the atrial syncytium, and the ventricular syncytium
What are the phases of the action potetial in the heart?
Phase 0 (depolarization). Membrane potential becomes more positive. Voltage-gated sodium channels (fast sodium channels) open and permit sodium to rapidly flow into the cell and depolarize it.
Phase 1 (initial repolarization). The fast sodium channels close, the cell begins to repolarize, and potassium ions leave the cell through open potassium channels.
Phase 2 (plateau). L-type calcium channels (slow calcium channels, or calcium -sodium channels) open and fast potassium channels close. A brief initial repolarization occurs and the action potential plateaus due to (1) increased Ca permeability and (2) decreased K permeability. The voltage-gated Ca channels open slowly on phases 1 and 0, and Ca enters the cell, K channels then close. Combination of low K efflux and high Ca influx maintains a prolonged depolarization period, causing the action potential to plateau.
Phase 3 (rapid repolarization), Ca channels close and slow K channels open. This permits K ions to rapidly exit the cell, ending the plateau and returning the cell membrane potential to its resting level.
Phase 4 (resting membrane potential)
Define systole and diastole.
Diastole is the period of relaxation, during which the heart fills with blood.
Systole is the period of contraction.
Diastole - deja - release - relax / Systole - sigue - continue - contract
What are P, Q, R, S and T waves on the ECG ?
Mention their relationship with the heart cycle.
P wave - caused by spread of depolarization through the atria. It is followed by atrial contraction causing a slight rise in the atrial pressure curve.
QRS waves - are a result of electrical depolarization of the ventricles. This initiates contraction of the ventricles and causes the ventricular pressure to rise. QRS complex begins slightly before ventricular systole.
T wave - represents repolarization of the ventricles when the ventricular muscle fibers begin to relax. Occurs slightly before the end of ventricular contraction.
What does a, c, and v mean in the atrial pressure wave??
a wave - caused by atrial contraction.
c wave - the ventricles begin to contract; caused partly by slight backflow of blood into the atria, but mainly by bulging of the A-V valves backward toward the atria (due to increasing pressure in the ventricles).
v wave - occurs toward the end of ventricular contraction. It results from slow flow of blood into the atria from the veins
What is the period of isovoluic contraction?
It is the period when contraction is occurring in the ventricles, but no emptying occurs (period of isovolumic or isometric contraction).
Ocurrs after ventricular contraction begins, the ventricular pressure rises abruptly, causing the A-V valves to close. Time is required for the ventricle to build up sufficient pressure to push the semilunar valves open against the pressures in the aorta and pulmonary artery.
Mention 3 important aspects of the period of ventricular ejection.
- When ventricular pressure rises pushing the semilunar valves open, 60% of the blood in the ventricle is ejected during systole
- The first third is called the period of rapid ejection (about 70% of this portion flows out during theses period).
- The last two thirds are called the period of slow ejection (the remaining 30% empties during these period).
Mention the relationship of the heart sound with the heart cycle.
First heart sound (S1) - Contraction of the ventricles. First a sound caused by closure of the A-V valves is heard (vibration pitch is low and relatively long-lasting)
Second heart sound (S2) - When aortic and pulmonary valves close at the end of systole. A a rapid snap (valves close rapidly), and the surroundings vibrate for a short period.
Third heart sound (S3) - Occurs at the beginning of the middle 3rd of diastole. It is believed that is caused by the oscillation of blood back and forth between the walls of the ventricles initiated by inrushing blood from the atria.
Fourth heart sound (S4) - Atrial contraction sound. Presumably, it is caused by the inrush of blood into the ventricles, which initiates vibrations similar to those of the third heart sound.
Mention the 4 phases during the cardiac cycle.
- Phase I: Period of filling. The amount of blood that remains in the ventricle after the previous heartbeat, is called end-systolic volume
- Phase II: Period of isovolumic contraction. Volume of the ventricle does not change (all valves are closed), however, the pressure inside the ventricle increases.
- Phase III: Period of ejection. Systolic pressure rises and volume of the ventricle decreases.
- Phase IV: Period of isovolumic relaxation. At the end of the period of ejection the aortic valve closes and the ventricular pressure falls back to the diastolic pressure.
What is the Frank-Starling mechanism?
It is the ability of the heart to adapt to increasing volumes of inflowing blood. It means that the greater the heart muscle is stretched during filling, the greater is the force of contraction and the greater the quantity of blood pumped into the aorta.
In addition to the important effect of lengthening the heart muscle, the stretch of the right atrial wall directly increases the heart rate by 10 to 20%, which also helps increase the amount of blood pumped each minute, (this contribution is less than the Frank-Starling mechanism).
What is the effect of sympathetic and parasympathetic stimulation of the heart?
Strong sympathetic stimulation can increase the heart rate. It can also increase the force of heart contraction to as much as double the normal rate, increasing the volume of blood pumped and increasing the ejection pressure.
Parasympathetic (Vagal) stimulation reduces HR and strength of contraction. Strong stimulation of the vagus nerves to the heart can stop the heartbeat for a few seconds, but then the heart usually “escapes” and beats at a lower rate as long as the parasympathetic stimulation continues. Vagal stimulation can also decrease the strength of heart muscle contraction by 20 - 30%
What is the effect of K and Ca ions in the heart?
Excess K causes the heart to become dilated and flaccid and also slows the heart rate. It can block conduction of the cardiac impulse from the atria to the ventricles through the A-V bundle.
This results because high K concentration decreases the resting membrane potential and partially depolarizes the cell membrane, causing the membrane potential to be less negative. This decreases the intensity of the action potential, making contraction of the heart progressively weaker.
Excess Ca effect is almost exactly opposite to K, Ca ions initiate the cardiac contractile process, causing the heart to move toward spastic contraction. Conversely, deficiency of calcium ions causes cardiac weakness.