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General Exam ACVIM > Interleukins > Flashcards

Interleukins Flashcards

1
Q

IL-1 source

A

Macrophages

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2
Q

IL-1 activity

A

lymphocyte activating factor; stem. T cells and APC; B-cell growth and ab production. Promotes hematopoiesis

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3
Q

IL-2 source

A

Activated T cells (MHC I, CD8+)

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4
Q

IL-2 Target: activity

A

T cells: proliferation and differentiation into effector and memory cells; promotes regulatory T cell development, survival, and function
NK cells: proliferation, activation
B cells: proliferation, antibody synthesis (in vitro)

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5
Q

IL - 4 Source

A

CD4+ T cells, (Th2), Mast cells

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6
Q

IL - 4 Target: Activity

A

B cells: isotype switching to IgE
T cells: T H 2 differentiation, proliferation
Macrophages: alternative activation and inhibition of IFN-γ–mediated classical activation
Mast cells: proliferation (in vitro)

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7
Q

IL - 5 source

A

CD4+ T cells (Th2)

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8
Q

IL - 5 Target: activity

A

Eosinophils: activation, increased generation

B cells: proliferation, IgA production (in vitro)

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9
Q

IL - 6 source

A

Macrophages, endothelial cells, T cells

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10
Q

IL - 6 target: activity

A

Liver: synthesis of acute-phase protein
B cells: proliferation of antibody-producing cells.

Induction of fever, synergistic w/ TNFa

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11
Q

IL - 7 source

A

Fibroblasts, bone marrow stromal cells; thymus

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12
Q

IL - 7 target: activity

A

Immature lymphoid progenitors: proliferation of early T and B cell progenitors
T lymphocytes: survival of naive and memory cells

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13
Q

IL - 8 source

A

Macrophages

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14
Q

IL - 8 target: activity

A

chemoattracts neutrophils produced by monocytes and hepatocytes

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15
Q

IL - 9 source

A

CD4+ T cells

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16
Q

IL - 9 target: activity

A

Mast cells, B cells, T cells, and tissue cells: survival and activation

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17
Q

IL-10 source

A

Activated T cells (Th2), b cells, & monocytes - OR - Macrophages and Treg

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18
Q

IL -10 target: activity

A 
cytokine synthesis inhibitory factor; inhibits production of IL-2 and interferon gamma by Th1 -OR-
Macrophages, dendritic cells: inhibition of expression of IL-12, costimulators, and class II MHC
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19
Q

IL - 11 source

A

Bone marrow stromal cells

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20
Q

IL - 11 target: activity

A

Production of platelets

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21
Q

IL-12 source

A

Macrophages, dendritic cells

22
Q

IL -12 target: activity

A

T cells: T H 1 differentiation

NK cells and T cells: IFN-γ synthesis, increased cytotoxic activity

23
Q

IL-13 source

A

CD4 + T cells (T H 2), NKT cells, group 2 innate lymphoid cells, mast cells

24
Q

IL -13 target: activity

A

B cells: isotype switching to IgE
Epithelial cells: increased mucus production
Fibroblasts: increased collagen synthesis
Macrophages: alternative activation

25
Q

IL-15 source

A

Macrophages, other cell types

26
Q

IL -15 target: activity

A

NK cells: proliferation

T cells: survival and proliferation of memory CD8 + cells

27
Q

IL-16 source

A

T cells, mast cells, eosinophils, epithelial cells

28
Q

IL -16 target: activity

A

CD4 + T cells, monocytes, and eosinophils: chemoattractant

29
Q

IL-17 source

A

CD4 + T cells (T H 17), group 3 innate lymphoid cells

30
Q

IL -17 target: activity

A

Endothelial cells: increased chemokine production
Macrophages: increased chemokine and cytokine production
Epithelial cells: GM-CSF and G-CSF production

31
Q

IL-18 source

A

Monocytes, macrophages, dendritic cells, Kupffer cells, keratinocytes, chondrocytes, synovial fibroblasts, osteoblasts

32
Q

IL -18 target: activity

A

NK cells and T cells: IFN-γ synthesis
Monocytes: expression of GM-CSF, TNF, IL-1β
Neutrophils: activation, cytokine release

33
Q

IL-19 source

A

Macrophages

34
Q

IL -19 target: activity

A

Macrophages: stimulates IL-1 and TNF secretion
Keratinocytes: proliferation

35
Q

IL-21 source

A

T H 2 cells, T H 17 cells, T FH cells

36
Q

IL -21 target: activity

A

B cells: activation, proliferation, differentiation
T FH cells: development
T H 17 cells: increased generation
NK cells: functional maturation

37
Q

IL-23 source

A

Macrophages, dendritic cells

38
Q

IL -23 target: activity

A

T cells: differentiation and expansion of T H 17 cells

39
Q

IL-25 source

A

T cells, mast cells, eosinophils, macrophages, mucosal epithelial cells

40
Q

IL -25 target: activity

A

T cells and various other cell types: expression of IL-4, IL-5, IL-13

41
Q

IFNa source

A

Plasmacytoid dendritic cells, macrophages

42
Q

IFNa target: activity

A 
All cells: anti-viral state, increased class I MHC expression 
NK cells: activation
43
Q

IFNb source

A

Fibroblasts, plasmacytoid dendritic cells

44
Q

IFNb source

A 
All cells: anti-viral state, increased class I MHC expression 
NK cells: activation
45
Q

IFNgam source

A

T cells (T H 1, CD8 + T cells), NK cells

46
Q

IFNgam source

A 
Macrophages: classical activation (increased microbicidal functions) 
B cells: isotype switching to opsonizing and complement-fixing IgG subclasses (established in mice) 
T cells: T H 1 differentiation 
Various cells: increased expression of class I and class II MHC molecules, increased antigen processing and presentation to T cells
47
Q

IL-22 source

A

Th17 cells

48
Q

IL - 22 target: activity

A

Epithelial cells: production of defensins, increased barrier function
Hepatocytes: survival

49
Q

TNF source

A

Macrophages, NK cells, T cells

50
Q

TNF target: activity

A

Endothelial cells: activation (inflammation, coagulation)
Neutrophils: activation
Hypothalamus: fever
Muscle, fat: catabolism (cachexia)

51
Q

TGF - beta (Transforming growth factor) source

A

T cells (mainly Tregs), macrophages, other cell types

52
Q

TGF - beta target:activity

A

T cells: inhibition of proliferation and effector functions; differentiation of T H 17 and Treg
B cells: inhibition of proliferation; IgA production
Macrophages: inhibition of activation; stimulation of angiogenic factors
Fibroblasts: increased collagen synthesis

General Exam ACVIM (17 decks)

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