The Guide Flashcards
The Guide IACUC Composition Rules
No minimum
Must have:
Veterinarian with program authority
Non-affiliated member
Practicing scientist
Inspection Requirements from The Guide
2 voting members
The Guide on Delivering Annual Report to IO
No mention on how this must be done
Per The Guide, how often must an IACUC meet?
As often as needed, minimum of every 6 months
Which document describes the training requirements for an IACUC?
The Guide
(NOT mentioned in AWA)
What is The Guide’s definition of an ANIMAL
Any warm-blooded animal
Which document describes training requirements for IACUC Members?
The Guide (p9)
According to the Guide, Identification/Cage Cards should include…?
Source of the animal, strain or stock, names and locations of the responsible investigators, pertinent dates, and protocol number
What the Guide says about Multiple Major Survival Surgery?
The guide discourages multiple major survival surgery
The Guide suggests that reasons for multiple major survival surgery may include procedures that are related components of a research project, procedures that will conserve scarce animal resources, or procedures conducted for clinical reasons. The Guide precludes cost savings as the soul justification for multiple major survival surgery. Subsequent to approval of multiple major survival surgery the IACUC should ensure that there is sufficient ongoing oversight of the project.
How does The Guide define laboratory animals?
Any vertebrate animal (literally any, including wildlife) produced for or used in research, testing, or teaching.
How does The Guide define animal use?
The proper care, use, and humane treatment of laboratory animals produced for or used in research, testing, or teaching
How does The Guide define humane care?
Actions taken to ensure that laboratory animals are treated according to high ethical and scientific standards.
How does The Guide define animal care and use program?
The policies, procedures, standards, organizational structure, staffing, facilities, and practices put into place by an institution to achieve the humane care and use of animals in the laboratory and throughout the institution.
How does The Guide define an engineering standard?
A standard or guideline that specifies in detail a method, technology, or technique for achieving a desired outcome.
It does not provide for modification in the event that acceptable alternative methods are available or unusual circumstances arise.
They are prescriptive and provide limited flexibility for implementation, but can be useful to establish a baseline and relatively easy to use when evaluating compliance.
How does The Guide define performance standard?
A standard or guideline that, while describing a desert outcome, provides flexibility in achieving this outcome by granting discretion to those responsible for managing the animal care and use program, the researcher, and the IACUC.
The desired outcomes and/or goals must be clearly defined and appropriate performance measures regularly monitored in order to verify the success of the process.
They accommodate the consideration of many variables so that the implementation can be best tailored to meeting the recommendations in the guide.
How does The Guide define practice standard?
The application of professional judgment by qualified, experienced individuals to a task or process over time, and approach that has been demonstrated to benefit or enhance animal care and use.
This can come from information in the peer-reviewed scientific literature, textbooks, and from time proven experiences in the field.
In the absence of public scientific literature or other definitive sources, where experiences demonstrated that the particular practice improves animal care and use, practice standards have been used in determining appropriate recommendations in the Guide
How does The Guide define policies?
Policies are commonly derived from a public agency or private entity. They are generally practical statements of collective wisdom, convention, or management direction that are internal to the entity.
Policies may assume broader force when they become the means by which and implementing agency interprets existing statutes, such as the PHS policy.
How does The Guide define principles?
Principles are broader in scope and intended application, and are accepted generalizations but a topic that are frequently endorsed by many and diverse organizations, such as the US government principles.
How does the guide define procedures?
Procedures (often called operating procedures or standard operating procedures) are typically detailed step by step processes meant to ensure the consistent application of institutional practices.
Establishing SOPs can assist an institution in complying with regulations, policies, and principles as well as with day-to-day operations.
Must v Should v May
Must indicates actions that are considered an imperative and mandatory duty or a requirement for providing humane animal care and use.
Should indicates a strong recommendation for achieving a goal, however circumstances might justify an alternative strategy.
May indicates a suggestion to be considered.
Responsibilities and Involvement of the IO
Bears ultimate responsibility for the program, though overall program direction should be a shared responsibility among IO, AV, and IACUC.
The IO has the authority to allocate necessary resources to ensure overall program effectiveness.
The IO represents senior administration at the institution and his responsible for resource planning and ensuring alignment of program goals with the Institution’s mission.
Responsibilities and Involvement of the AV
The AV is responsible for the health and wellbeing of all lab animals used at the institution.
The institution must grant the AV sufficient authority, including access to all animals and resources to manage their program of veterinary care.
AVs you should also oversee other aspects of animal care and use to ensure that the program complies with the guide.
AVs may be full-time, part-time, or consultative, as the needs and size of the program suggest.
If AVs are not full-time, there must be an individual with a signed responsibility for daily animal care and use and facility management.
Responsibilities and Involvement of the IACUC
The IACUC is responsible for assessment and oversight of the Institution’s program components and facilities.
