The endocrine pancreas Flashcards
What is secreted from the d-cells of the endocrine pancreas?
Somatostatin
Which cells secrete pancreatic polypeptide?
The F cells
Are insulin and glucagon water soluble?
Yes
Is insulin an anabolic or catabolic hormone?
Anabolic
What hormone am I describing? “It consists of two un-branched peptide chains which are connected by 2 di-sulphide bridges this ensures stability”
Insulin
Preproinsuilin -> proinsulin involves the excision of the …….. ….. and ……. ……. to form
It involves the excision of the signal peptide and disulphide bonds to form
Which receptor does glucose use to move into B cells?
Glut 2 cells
How does insulin increase glucose uptake?
Glut 4 insertion
What effect does insulin have on muscles?
Increased uptake of amino acids leading to increased protein synthesis
Margination is seen in glucagon and insulin. What is margination?
It is the movement of storage vesicles to the cell surface
What effects does glucagon cause in the liver?
Increased glycogenolysis
What is diabetes inspidus?
An uncommon condition that occurs when the kidneys are unable to conserve water as they perform their function of filtering blood
What is insulin resistance?
The main sites of glucose utilisation show decreased response to normal circulating concentrations
Where are enzymes from the pancreas secreted into?
The duodenum
