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Immunology Block 1 > The cytokines > Flashcards

The cytokines Flashcards

1
Q

who secretes TNF?

A

macrophages and T cells

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2
Q

what does TNF do to endothelial cells?

A

activates them causing inflammation and coagulation

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3
Q

what does TNF do to neutrophils?

A

activates them

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4
Q

what does TNF do to other cells?

A

induces apoptosis

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5
Q

Who secretes IL-1?

A

macrophages and endothelial cells

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6
Q

what does IL-1 do in endothelial cells?

A

inflammation

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7
Q

who secretes chemokines?

A

macrophages, dendritic cells, endothelial cells, T cells

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8
Q

what will chemokines do to leukocytes?

A

increase integrin affinityattract leukocytes to site of infection

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9
Q

who secretes IL-12?

A

dendritic cell and macrophages

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10
Q

what does IL-12 do to T cells?

A

causes the differentiation into TH1

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11
Q

What does IL-12 do to NK cells?

A

causes the release of IFN-y

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12
Q

What are the 2 type 1 interferons?

A

alpha and beta

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13
Q

who secretes type 1 interferon alpha?

A

dendritic cells and macrophages

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14
Q

who secretes type 1 interferon beta?

A

fibroblasts

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15
Q

what do type 1 interferons do in all cells?

A

they are anti-viral and increse MHC 1 expression

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16
Q

what will type 1 interferons do to NK cells?

A

they will activate them

17
Q

who secretes IL-10?

A

macrophages, dendritic cells and Tcells

18
Q

what does IL-10 do to macrophages and dendritic cells?

A

it inhibits IL-2, IL-12 and IL-5 production

reduces co-stimulatorsreduces MHC 2

19
Q

what does IL-10 do to T cells?

A

it will inhibit activated t cells

20
Q

what does IL-6 do?

A

will cause B cells to become plasma cells

21
Q

who secretes IL-6?

A

macrophages and T cells

22
Q

Who secretes IL-15

A

Macrophages

23
Q

What does IL-15 do?

A

Causes Natural killer cells and T cells to proliferate

Immunology Block 1 (5 decks)

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