The cytokines Flashcards
who secretes TNF?
macrophages and T cells
what does TNF do to endothelial cells?
activates them causing inflammation and coagulation
what does TNF do to neutrophils?
activates them
what does TNF do to other cells?
induces apoptosis
Who secretes IL-1?
macrophages and endothelial cells
what does IL-1 do in endothelial cells?
inflammation
who secretes chemokines?
macrophages, dendritic cells, endothelial cells, T cells
what will chemokines do to leukocytes?
increase integrin affinityattract leukocytes to site of infection
who secretes IL-12?
dendritic cell and macrophages
what does IL-12 do to T cells?
causes the differentiation into TH1
What does IL-12 do to NK cells?
causes the release of IFN-y
What are the 2 type 1 interferons?
alpha and beta
who secretes type 1 interferon alpha?
dendritic cells and macrophages
who secretes type 1 interferon beta?
fibroblasts
what do type 1 interferons do in all cells?
they are anti-viral and increse MHC 1 expression
what will type 1 interferons do to NK cells?
they will activate them
who secretes IL-10?
macrophages, dendritic cells and Tcells
what does IL-10 do to macrophages and dendritic cells?
it inhibits IL-2, IL-12 and IL-5 production
reduces co-stimulatorsreduces MHC 2
what does IL-10 do to T cells?
it will inhibit activated t cells
what does IL-6 do?
will cause B cells to become plasma cells
who secretes IL-6?
macrophages and T cells
Who secretes IL-15
Macrophages
What does IL-15 do?
Causes Natural killer cells and T cells to proliferate
