The Cornea Flashcards
What is the difference in presentation between a primary corneal infection with HSV1 and a reactivation of HSV1?
Asymptomatic plaques that heal w/o ulceration versus corneal ulceration and more severe inflammatory rxn
How are HSV lesions of the cornea visualized?
Fluorescein
What is the name for HSV-affected epithelial cells?
Lipschuetz bodies
What is the name for the disc shaped corneal opacity beneath the epithelium in, owing to edema in an HSV cornea?
Disciform keratitis
What is the common name for Onchocerciasis? What is the bug?
River blindness; Onchocerca volvulus
What is Arcus Lipoides and what causes it?
White arc due to lipid deposition in peripheral cornea
What is Band Keratopathy?
Opaque horizontal band across cornea containing either phosphate or noncalcified protein
What is Calcific Band Keratopathy? What condition can it be associated with?
Calcium Phosphate deposited in horizontal line across cornea; Hypercalcemia
What is Chronic actinic keratopathy caused by?
Excessive exposure to UV
What type of genetic inheritance are most corneal dystrophies?
Autosomal dominant, rare cases of X linked recessive
What is Meesmann dystrophy? What genes are commonly affected and what do they code for?
Genetic corneal epithelial dystrophy; KRT3 and KRT12; Code for keratin 3 and 12, respectively
What is familial subepithelial corneal dystrophy? What gene is affected? What is found under the corneal epithelium?
Genetic corneal epithelial dystrophy; TACSTD2; amyloid
Name the gene that is commonly mutated in corneal stromal dystrophies
TFGBI gene
What is the Descemet membrane?
Basement membrane betwixt the corneal proper substance (stroma) and the endothelial layer of the cornea
What is the gene mutated that is associated (and mutation) with Fuchs endothelial corneal dystrophy?
Missense mutation in COL8A2
