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Unit 3: Pathology - CH29 The Eye > Ocular Neoplasms > Flashcards

Ocular Neoplasms Flashcards

1
Q

From what cell does retinoblastoma come from?

A

Immature retinal neurons

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2
Q

From what cells do melanomas come from?

A

Melanocytes

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3
Q

What cells can uveal melanomas be composed of?

A

Spindle A cells, Spindle B cells, Epithelioid cells, and a smaller epithelioid cell

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4
Q

What is a Spindle A cell?

A

Spindle-shaped cell w/o nucleoli

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5
Q

What is a Spindle B cell?

A

Spindle-shaped cell w/ prominent nucleoli

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6
Q

What is an Epithelioid cell?

A

Polygonal cell with distinct cell borders and prominent nucleoli

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7
Q

Describe lymphatic spread of ocular melanomas

A

Lymphatic spread does not occur

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8
Q

By what methods do ocular melanomas spread?

A

Hematogenous and traversing scleral tissues to enter the orbital tissues

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9
Q

What is a clue for Dx of ocular melanoma?

A

Enlarged liver and a patient with a “glass eye”

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10
Q

What type of melanomas have the worst prognosis?

A

Epithelioid cells

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11
Q

What is the genetic cause of retinoblastoma?

A

Either inherited or acquired deletion of/mutations in Rb tumor suppressor gene located on 13

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12
Q

What is an endophytic retinoblastoma?

A

Rbs that grow towards the vitreous humor

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13
Q

What is an exophytic retinoblastoma?

A

Rbs that grow betwixt the sensory retina and the retinal pigment epithelium thereby detaching the retina

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14
Q

What are Flexner-Wintersteiner rosettes?

A

Cells arranged radially around a central cavity as they differentiate towards photoreceptors

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15
Q

What are the routes of spread of retinoblastoma?

A

Optic nerve intracranially, hematogenous

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16
Q

What are the clinical findings of retinoblastoma?

A

Leukocoria, strabismus, poor vision, spontaneous hyphema or a red painful eye

17
Q

What is hyphema?

A

Blood in the anterior chamber of the eye

18
Q

What is the most common type of eye cancer?

A

Secondary metastatic eye tumors

Unit 3: Pathology - CH29 The Eye (12 decks)

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