the cell cycle, cell growth, death and differentiation Flashcards
define the cell cycle
the cycle of stages that take place in a cell as it grows and divides to produce new daughter cells
define the three components that new cells are needed constantly for
- Growth and development
- Maintenance and repair
- Reproduction
define growth and development
all humans begin as a single cell: from there we replicate rapidly, becoming an embryo, foetus, and then a baby. As we grow larger, our cells dont become larger. Instead, we are simply made of more cells. Therefore, for a multicellular organism to grow and develop, it is important that cells replicate.
define maintenance and repair
cells are constantly dying as they age or become more damaged. Cell replication allows these cells to be replicated, ensuring the proper functioning of an organism.
define reproduction
prokaryotic and eukaryotic cells replicate to reproduce. When they replicate, they are enlarging their population.
prokaryotic cells cycle consists of _________. This is ________
prokaryotic cells cycle consists of binary fission. This is the asexual reproduction process by which one prokaryotic cell divides into two genetically identical daughter cells.
define asexual reproduction
a method of reproduction that produces genetically identical cells without the fusion of gametes (sex cells)
define plasmid
a small, circular loop of DNA that is seperate from a chromosomes, typically found in bacteria.
define septum
a dividing wall formed during binary fission
define the first step of binary fission
define the second step of binary fission
define the third step of binary fission
define the fourth step of binary fission
define the fifth step of binary fission
cytokinesis definition
the division of the cytoplasm and even distribution of organelles as the plasma membrane pinches in the formation of two seperate nuclei, producing two daughter cells
recall the three stages of the eukaryotic cell cycle
- Interphase
- Mitosis
- Cytokenesis
define the interphase
the interphase is the longest stage of the eukaryotic cell cyclev where the cell synthesises the necessary DNA, proteins and organelles required for growth and replication. At this time, DNA in the nucleus exists as long chromatin threads instead of discrete chromosomes.
Identify the three substages of the interphase
- G1 phase
- S phase
- G2 phase
- If further cell replication is not required, the cell can exit the cycle during the G1 phase and enter the G0 (resting phase)
define the G0/ Gap phase
cells that are not required to replicate rest in the G0 phase. Cells in G0 are either quiescent or terminally differentiated. While quiescent cells are dormant and have the ability to re-enter the cell cycle, terminally differentiated cells remain in G0 indefinitely.
define quiescent cells
dormant cells which can re-enter the cell cycle
define terminally differentiated cells
cells that have fully specialised and no longer replicate
define the G1 phase
cells grow by increasing the volume of its cytosol, synthesising proteins for DNA replication and replicating its organelles. At the end of the G1 phase, the cell can either proceed to the S phase or exit the cell cycle and enter the G0 phase.
fill in
define chromosome
a structure composed of DNA tightly wrapped around histone proteins. Carries genetic information (genes) of a cell.
define sister chromatids
the two identical halves of a replicated chromosome
define chromatin
chromosomes (DNA and proteins) that have been unwound and loosely packed during the interphase.
define the G2 phase
during the G2/S phase, the cell replicates its DNA turning one chromosome into two genetically identical sister chromatids. Similarities to G1 phase in that it involves: increasing the volume of the cytosol, synthesizing proteins in preparation for mitosis.
define mitosis
mitosis is the second stage of the eukaryotic cell cycle and involves the seperation of the newly replicated chromosomes into two new Genetically identical nuclei.
identify the 4 stages of mitosis
- Prophase
- Metaphase
- Anaphase
- Telophase
define prophase
chromosomes supercoil/condense and become visible, centrioles move apart to opposite poles and spindle fibres begin to form. Nucleur membrane begins to breakdown.
define metaphase
chromosomes appear as two sister chromatids joined at the centromere, chromosomes lines up at the equator, microtubules of spindle attach to centromere.
define anaphase
microtubules/spindle fibres contract, splitting the centromere and pulling sister chromatids to opposite ends of the cell. Chromatids are now considered new chromosomes.
define telophase
the chromosomes densely pack together at either end of the cell and new nucleur membranes form, producing two genetically identical nuclei. The spindle fibres disintegrate and the chromosomes decondense.
identify the stage of mitosis
identify the stage of mitosis
identify the stage of mitosis
identify the stage of mitosis
define chromosome condensation
the shortening and thickening of chromosomes, as DNA is tightly wrapped around histone proteins
define centrioles
cylindrical structures composed of protein which form the spindle fibres during mitosis and meiosis
define spindle fibres
structures which aid in the movement of chromosomes to either pole of the cell during mitosis or meiosis
define equator
the centre line between oppposite ends of the cell that the chromosomes line up on during metaphase
define cleavage furrow
an indentation of the plasma membrane during cytokenesis
define cell plate
a component involved in the formation of a cell wall
define cytokenesis in animal cells
this occurs when a cleavage furrow develops and pinches the plasma membrane into two cells
fill in
fill in
define cytokenesis in plant cells
because they have a cell wall, a cell plate first forms at the equator before seperating into two cells.
describe cell cycle regulation
if errors are detected at checkpoints the cell either repairs itself of will undergo programmed cell death - apoptosis
what does apoptosis ensure
that malfunctioning, damaged and cells that are no longer needed are removed from the body
recall the three checkpoints in the eukaryotic cell cycle
- G1 checkpoint
- G2 checkpoint
- Metaphase checkpoint
define the G1 checkpoint
verifies that the cell has grown the correct size, has synthesised enough proteins for DNA replication, and checks if the DNA has been damaged during mitosis and cell growth
define the G2 checkpoint
ensures that DNA has replicated properly in the S phase, and that the cell has enough resources for mitosis
define the metaphase checkpoint
the cell checks the formation of the spindle fibres. If the chromosomes are lined up in the correct location, fibres attach then the cell proceeds to anaphase
describe possible problems in the checkpoints
checkpoints in the cell cycle detect and repair cell and DNA damage before the cell replicates. But mutagens/ DNA mutations or individual genetics can cause checkpoints to malfunction
define apoptosis
the controlled death of cells in the body. Also known as programmed cell death.
recall the two pathways for apoptosis
- Mitochondrial pathway
- Death receptor pathway
define the mitochondrial pathway
the pathway of apoptosis which is initiated by the detection of internal cellular damage. Also known as the intrinsic pathway,
intrinsic pathway definition
internal pathway triggered by internal signals
define the death receptor pathway
the pathway of apoptosis which is initiated by the detection of external cellular damager. Also known as the extrinsic pathway.
extrinsic pathway definition
external pathway triggered by signals external to the cell
define caspase enzymes
catalysts that cleave/ split specific intracellular proteins during apoptosis
define Cyrochrome C
a protein embedded in the inner mitochondrial membrane
define blebbing
the bulging of the plasma membrane to form apoptic bodies
define apoptotic bodies
vesicles containing cell contents that are released from a dying cell during apoptosis and engulfed by phagocytes
phagocyte definition
a cell of the immune system responsible for engulfing and destroying harmful micro-organisms and foreign material
define phagocytosis
endocytosis of solid material or food particles
recall the 4 steps of apoptosis
- Activation of Caspase
- Digestion of cell contents
- Cell shrinks
- Membrane blebbing and breakage
define step 1 of apoptosis
the mitochondria detect internal DNA damage and release Cytochrome C
define step 2 of apoptosis
caspases cleave/split intracellular proteins, which leads to the breakdown of organelles
define step 3 of apoptosis
the cell and nucleus shrink as intracellular material is broken down
define step 4 of apoptosis
as the cytoskeleton is digested, the structural integrity of the cell is weakened. The cell warps and breaks down into membrane-enclosed vesicles known as apoptotic bodies which contain the broken down intracellular material.
what happens after apopotosis
phagocytes engulf and digest the free floating apoptotic bodies during phagocytosis
define necrosis
necrosis is the unregulated deaths of cells initiated by significant damage which causes the cell to swell, burst, and release cell contents into the surrounding environment. This may lead to inflammation and damage in nearby cell tissues.
what can mutagens do?
mutagens such as UV, nucleur radiation or certain chemicals can change the base code of DNA - mutating it. They can make non-functioning or hyper-functioning proteins that dont work or overstimulate the cell cycle.
define proto-oncogenes
responsible for maintaining and promoting the growth and development of cells. A mutated proto-oncogene can become an oncogene, which leads to the uncontrollable growth of cells due to over-stimulation of growth signals.
define tumour surpressor genes
negative regulators of the cell cycle that can inhibit cell growth and promote apoptosis in damaged cells. When they mutate the cell cycle often remains unregulated, resulting in the rapid unimpended production of cells.
define tumour
a mass of abnormal cells
define benign tumor
a tumor that lacks the ability to spread throughout other tissues and organs
define malignant tumor
abnormal cells with the ability to invade nearby tissue and migrate to other parts of the body. Also known as cancerous cells
define cancer
a disease caused by the uncontrolled replication of cells with the ability to migrate to other parts of the body
define metastasis
the migration of tumor cells from the primary tumor site to distant parts of the body
recall the five characteristics of tumors
- Self sufficiency
- Antigrowth deactivation
- Increased survival
- Blood supply formation
- Tissue invasion and metastisis