the basis of behaviour Flashcards
What does the agonist do?
it mimics neurotransmitter action
What does the antagonist do?
it opposes action of a neurotransmitter
What can drugs do to synapses?
It can block receptor sites
How do neurotransmitters bind to receptor sites?
Lock and key method
What are monoamines?
dopamine, norepinephrine, and serotonin
What causes Parkinson’s?
Low levels of dopamine (da)
What causes schizophrenia?
High levels of dopamine
What causes depression?
low levels of norepinephrine (ne)
What does serotonin control?
Sleep and aggression
What can low levels of serotonin cause?
Eating disorders & OCD- dysregulation of 5HT sites (low levels of 5HT)
What does GABA do?
Produce inhibitory PSP’s
What does glutamate do?
excitatory
Involved in learning & memory
What do endorphins do?
mimic opiates & induce pleasure
Functions of acetylcholine?
- activates motor neurons controlling skeletal muscles
- contributes to the regulation of attention, arousal, and memory
- some ACh receptors can be stimulated by nicotine
Functions of dopamine
- contributes to control of volountary movement, pleasureable emotions
- decreased levels are associated with Parkinson’s
- overactivity at da synapses are associated with schizophrenia
- cocaine and amphetamines elevate activity at da synapses
functions of norepinephrine
- contributes to modulation of mood and arousal
- cocaine and amphetamines elevate activity at ne synapses
Functions of serotonin
- involved in regulation of sleep and wakefulness, eating, aggression
- abnormal levels contribute to depression and obsessive compulsive disorder
- prozac and similar medications affect serotonin circuits
functions of GABA
- serves as widely distributed inhibitory transmitter
- valium and similar antianxiety drugs work at gaba synapses