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Block 3 pharm > The Alcohols > Flashcards

The Alcohols Flashcards

1
Q

ADH Pathway

A
  • Convert Alcohol to Acetaldehyde

- Most of it occurs in the stomach

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2
Q

ALDH

A
  • Acetaldehyde to Acetate in Liver
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3
Q

Acute Alcohol Intox Rx

A

Glucose
Phosphate
Thiamine (Tx of Wernicke-Karsakoff Syndrome)
Potassium

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4
Q

Alcohol Withdrawal Rx

A
  • Substitute a Hypnotic for alcohol
  • Gradual Tapering Dose
    Chlordiazepoxide
    Diazepam
    Lorazepam (safer, not metabolized in liver)
    Oxazepam (safer, not metabolized in liver)
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5
Q

Tx of Alcoholism

A
  • Naltrexone: Reduces craving and relapse
  • Acamprosate: Weak NMDA antagonist, GABAa Agonist
  • Disulfiram: Inhibits ALDH inhibitor; Sweating, headache, nausea, etc. few minutes after drinking alcohol
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6
Q

Methanol Poisoning Rx

A

Ethanol
Fomepizole
Bicarb
Hemodialysis

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7
Q

Ethylene Glycol Poisoning Rx

A

Ethanol
Fomepizole
Hemodialysis

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Block 3 pharm (10 decks)

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