OTC & Pharmacogenomics Flashcards
1
Q
OTC Agents
A
Acetaminophen
Ibuprofen
Aspirin
Diphenhydramine
2
Q
Nasal Decongestants Misuse
A
- Rebound Congestion
- INC BP
3
Q
NSAIDs Misuse
A
- Impair ACE inhibitor effects by blocking Bradykinin vasodilation
4
Q
Antitussives Misuse
A
Addiction
5
Q
Antihistamines Misuse
A
Sedation
6
Q
Prescription Plant Drugs
A
Atropine
Digoxin
Morphine
7
Q
Saw Palmetto
A
- Rx for BPH (5AR Inhibitor)
8
Q
St John’s Wort
A
- Antidepressant
- Enhances Serotonin
9
Q
Ginkgo
A
- Rx of Alzheimer’s
- Intermittent Claudication
- Antioxidant
10
Q
Echinacea
A
- Rx of Common Cold
- Enhances interleukin
11
Q
Melatonin
A
- Insomnia and Jet Lag
- Serotonin Effects
12
Q
Ephedra
A
- Weight loss and congestion
- Sympathomimetic
13
Q
Ginseng
A
- Mental and Physical Enhancer
14
Q
Garlic
A
- Heart Dx and Cancer
- Inibits HMG-CoA reductase
- ACE inhibitors
15
Q
Dehydroepiandosterone
A
- Anti-aging
- SLE
- Androgen precursor
16
Q
Kava
A
- Rx of Anxiety
- Enhances GABA
17
Q
Feverfew
A
- Rx of migraine
- DEC LTs and PGs
18
Q
Milk Thistle
A
- Rx of Liver Dx
- Rx of Mushroom Poisoning
- Antioxidant
19
Q
Genetic Polymorphisms
A
- Substitution of a single base pair by another
20
Q
Succinylcholine (Genetic Polymorphisms)
A
- BCE Defect
- Prolonged Resp Paralysis
21
Q
Isoniazid (Genetic Polymorphisms)
A
- Slow Acetylators
- High incidence of peripheral neuritis
- SLE
22
Q
Procainamide (Genetic Polymorphisms)
A
- Slow Acetylator
- SLE
23
Q
6MP (Genetic Polymorphisms)
A
- TPMT Defect
- INC BMC
24
Q
CYP2D6 (GP)
A
- Poor metabolism of Tamoxifen (INC Risk of relapsed Breast Cancer)
- DEC Endoxifen
- CYP2C19*17 allele exhibit higher metabolic activation of Tamoxifen and Clopidogrel
25
Q
Ultra Rapid Metabolizers (GP)
A
- Saudi Arabians need high doses of Nortryptiline antidepressants
- Codeine - Morphine induced death of breastfeeding infant
26
Q
CYP2C9*3 (GP)
A
Warfarin Toxicity
27
Q
UGT1A1*28
A
- Gilbert Syndrome from impaired drug conjugation or elimination
28
Q
CYP2C9
A
- Warfarin Toxicity
- Phenytoin Toxicity
