Th Cells

Question 1

Th1

Answer 1

T-bet
IFN-gamma
Produces cytokines that activate macrophages to destroy intercellular microbes
Defence against intracellular parasites

Question 2

Th2

Answer 2

GATA3
IL4/5/13
Produces cytokines that promote humoral responses
Stimulates eosinophils, mast cells
Alternatively activated macrophages for tissue repair
‘Cellular and Ab responses to parasites’

Question 3

Th17

Answer 3

RORgamma3
IL-17
Antimicrobial immunity at epithelial barriers. Promotes recruitment of neutrophils to sites of infection.
Enhances neutrophil response to extracellular bacteria and some fungi

Question 4

Tfh

Answer 4

Bcl6
IL-6 activates, releases CXCR5
Help localise helper cells in B cell follicles and activate B cells
Isotope switching, affinity maturation

Question 5

Treg

Answer 5

FoxP3
TGFbeta, IL-10
Suppress T cell activity (protect from autoimmunity). Produces an anti inflammatory environment