Tetracyclines

Question 1

Tetracyclines are

Answer 1

broad spec Abx

Question 2

Tetracyclines used to tx

Answer 2

~ Chlamydia
~ Rickettsia
~ Brucella
~ Lyme disease
~ acne
~ periodontal
~ bronchitis
~ MRSA infections

Question 3

Tetracyclines MOA

Answer 3

INHIBIT BACTERIAL PROTEIN SYNTHESIS, BINDS TO RIBOSOMAL subunit
~ broad-spec + bacteriostatic

Question 4

Tetracyclines uses

Answer 4

lower UTIs, Acne, Rosacea, Malaria, Chlamydia

Question 5

Tetracyclines e.g.

Answer 5

~ tetracycline
~ oxytetracycline
~ demeclocycline
~ lymecycline
~ minocycline
~ doxycycline (malaria/chlamydia, OD)

Question 6

Tetracyclines SEs

Answer 6

Benign intracranial HTN
~ stop if headaches, visual disturbances

Question 7

Tetracyclines contra-indications

Answer 7

Children <12y
Pregnancy/BF
deposits in growing bone & teeth = teeth discoloration and dental hypoplasia

Question 8

Tetracyclines renal/hepatic impairment

Answer 8

Reanl
~ avoid, execpt doxycycline /Minocycline

Hepatic
~ are hepatotoxic, so avoid/caution

Question 9

Tetracyclines counselling point

Answer 9

1. Photosensitivity (DD,demeclocycline, dpxycycline )
2. Decreased absorption with antacids, Zn/Fe, Mg, Ca 2g before or after
3. Esophageal irritation