Quinolones

Question 1

Quinolones MOA

Answer 1

inhibits DNA synthesis

Broad-spec + bactericidal

Question 2

Quinolones use

Answer 2

lower RTIs, UTIs (avoid in MRSA infections as innate resistance)

Question 3

Quinolones e.g.

Answer 3

~ ciprofloxacin
~ levofloxacin
~ moxifloxacin (QT prolongation; Hepatotoxic)
~ nalidixic acid (1st gen; uncomplicated UTIs. Avoid in eGFR <20)
~ norfloxacin
~ ofloxacin

Question 4

Quinolones SEs

Answer 4

1. Seizures ~ lowers seizure thresholds
2. Tendon damage
3. QT prolongation
4. Arthropathy; avoid in pregnancy, children, young adults

DISCONTINUE IF PSYCHIATRIC, NEUROLOGICAL, HYPERSENSITIVTY REACTIONS OCCUR

Question 5

Quinolones interactions

Answer 5

~ increased risk of QT prolongation; ventricular arrythmias (SSRIs, Quinine, Amiodarone, Macrolides, Antipsychotics)

~ increased risk of seizures; Cipro & theophylline

~ NSAID induces convulsions

Question 6

Quinolones counselling points

Answer 6

~ Driving (impair driving)
~ antacids and zinc/iron ( leave 2h before or after taking quinolone avoid milk with ciprofloxacin)
~ Protect skin from sunlight