Tetracyclines Flashcards
What are indications of tetracyclines?
Acne
Chlamydia
Genital infections
MRSA infections
Resp infections
What is the mode of action of tetracyclines?
Inhibits bacterial protein synthesis
Brad spectrum
What bacteria are tetracyclines active against?
gram positive and negative: staph aureus, streptococcus pneumonia, haemophilus influenzaem neisseria gonorrhoeae and clostridium
What are the cautions and contraindications?
Causes teeth staining in children less than 12
Avoid in hepatic imapirment
Oxytetracycline can exacerbate renal fialure
Muscle weakness may be exacerbated in myasthenia gravis
What are the interactions? one major
Isotretinoin - increases the risk of intracranial hypertension.
May have been on for acne beforehand
Intracranial hypertension symptoms include headache, visual disturbance- discontinue if this occurs
What tetracyclines can be taken with milk?
Doxycycline, lymecyline and minocycline
DOES LIKE MILK
What patient and carer advice should you give to someone taking tetracyclines- specifically doxycycline?
Take with lots of water
Take after food
Requires skin protection
Can you take tetracyclines when pregnant or breastfeeding?
No because of the staining of teeth and bones
What is a tetracycline that has a broader spectrum of activity?
Minocycline - active against neisseria meningitis
What tetracycline has a long duration of action?
Doxycycline
What tetracycline is more associated with photosensitivity?
demeclocycline
What skin reactions are tetracyclines known for?
steven johnson syndrome
Systemic lupus erythrematosus
