Tetracycline Antibiotics Flashcards
How do tetracyclines work?
By inhibiting protein synthesis
What is the issue with tetracyclines?
They are broad spectrum antibiotics, but their value has dropped due to increasing bacterial resistance
Name 3 common tetracyclines?
- Tetracycline
- Doxycycline
- Tigecycline
What are the indications of the drug tetracycline?
IT IS THE SAME AS DOXYCYCLINE
- Exacerbation of COPD
- Chlamydia
- Lyme Disease
- Mycoplasma
- Rickettsiae
- Brucella
- Anthrax
- Syphilis
- MRSA
- Malaria prophylaxis
What are the indications of the drug doxycycline?
IT IS THE SAME AS TETRACYCLINE
- Exacerbation of COPD
- Chlamydia
- Lyme Disease
- Mycoplasma
- Rickettsiae
- Brucella
- Anthrax
- Syphilis
- MRSA
- Malaria prophylaxis
What are the indications of the drug tigecycline?
- Gram positive and gram negative infections including β-lactam-resistant strains
What are the side effects of tetracycline?
IT IS THE SAME AS DOXYCYCLINE
- Nausea and vomiting
- Clostridium difficile infection
- Fatty liver
- Idiopathic intracranial hypertension
What are the side effects of doxycycline?
IT IS THE SAME AS TETRACYCLINE
- Nausea and vomiting
- Clostridium difficile infection
- Fatty liver
- Idiopathic intracranial hypertension
What are the side effects of tigecycline?
- Nausea and vomiting
- Photosensitivity
- Increase in liver function test results
What are the contraindications for tetracyline and doxycycline?
Contraindicated in those who are
- Pregnant
- Under 8 years old
What is mycoplasma?
A genus of bacteria that lack a cell wall around their cell membranes (thus making them naturally resistant to antibiotics that target cell wall synthesis).
What is rickettsiae?
Gram-negative bacteria found in ticks, lice, fleas, mites, chiggers, and mammals
What is brucella?
Gram-negative bacteria causing illness
