tetracyclin

Question 1

what is the moa of tetracyclin

Answer 1

bind to the 30s
block the binding of aminoacetylated tRNA to the A site
prevent the growth of peptide chain
binding reversible

Question 2

what is the spectrum of activity of tetracyclin

Answer 2

rickettsia
mycoplasma 
chlymadid 
some gram negative 
spirochetes 
protozoa 
non-tb mycobacteria 
norcadia

Question 3

what are the indications of doxycycline

Answer 3

acne 
m.pneumonia 
cad 
chlymadia 
rickettsial infection 
pid 
mefloquinone and floroquinone resistant malaria px

Question 4

indication for monocyclin

Answer 4

leprosy

Question 5

what is the pk of tetracycylin q

Answer 5

A; GI good but incomplete dairy cc no affect
wide; urine, prostate and CSF, placenta NO
kidney elimination except doxy which has bile and reabsorption in enterrohepatic circulation