aminoglycosides Flashcards
1
Q
moa action aminoglycosides
A
inhibit protein synthesis
bind ir to 30 s causing cell membrane damage and cell death
enterance facilitated by aqueous channels formed on surface of bacteria by porin proteins
2
Q
what is the spectrum aminoglycosides
A
Serretia psudonomas acintobacter citrobacter enterrobacteriasis morgella providencia
3
Q
indication
A
serious -ve infection, systemic enterococcal and endocarditis
p.aeriginosa
px
4
Q
interesting point on pk
A
it doesnt go into mast cell and csf but increases when inflammation is present.m
