Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

IFM Study > Testosterone > Flashcards

Testosterone Flashcards

1
Q

What is primary testosterone deficiency?

A

Low T, Elevated LH/FSH (testicular failure)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is secondary testosterone deficiency?

A

Low T, low or normal LH/FSH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is criteria for testosterone deficiency diagnosis?

A
  1. Low T
  2. Signs/symptoms of low T.
  3. H&P findings consistent with low T.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are some comorbidities of low T?

A

DM, Metsyn, IR, depression, CVD, osteoporosis, sarcopenia, hypothyroid, sleep loss, leptin resistance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is low T a biomarker for?

A

cardiometabolic disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How does treating low T affect metsyn?

A

improves insulin sensitivity
improves body composition
improves lipid profiles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How does testosterone levels correlate with OSA?

A

Negatively correlated with severity of OSA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Does fixing OSA help testosterone levels?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How does sleep affect testosterone?

A

Less sleep esp <5 hours decreases levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Why does stress lower T?

A

Glucocorticoids inhibit GnRh

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is opioid effect on T?

A

Suppresses GnRh, dose dependant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What vitamin is needed for spermatogenesis?

A

Vitamin A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What mineral helps Cd toxicity?

A

Selenium(and Zn)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What mineral increases T?

A

Zinc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What mineral deficiency should be considered in pubertal arrest ?

A

Zinc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How does Vitamin D affect T?

A

It increases, free, total and bioactive forms T

17
Q

How does insulin, stress, leptin affect detox of testosterone?

A

It increases aromatase, 5 alpha reductase so less testosterone

18
Q

What are 4 nutritional supports for T?

A

Vitamin A, D, Se, Zn

19
Q

What is problem with Total Testosterone?

A

It has high false positive rate; Has low false negative rate so good at ruling out.

20
Q

What happens to SHBG as men age?

A

It increases

21
Q

What is biggest leverage point for low T?

A

Weight

22
Q

What inhibits 17,20 lyase?

A

Hyperinsulinemia
Stress
Inflammation
Licorice

23
Q

What stimulates 17,20 lyase?

A

Meditation

24
Q

What upregulates aromatase?

A 
Etoh
Zinc def
IR, stress, obesity, cortisol, leptin, aging
Inflammation PGE2
Gonadotropins
BPA
25
Q

What is BPA effect on SHBG?

A

Increases

26
Q

How does metabolic endotoxemia affect T?

A

Creates inflammation which produces IL1B, TNFa, IL6 and impairs testicular leydig steroidogenesis

27
Q

How does obesity affect T?

A

Adipose tissue has high aromatase
Heating of testicles by pelvic fat, oxidative stress, leptin
Increased expression of 11 b hydroxysteroid dehydrogenase in adipose tissue which coverts cortosol into inactive form.

28
Q

What endocrine disruptor plays a role in low T?

A

Pthalates

29
Q

What metals are associated with low T?

A

Cd, Pb, Hg

30
Q

What happens to testosterone/cortisol ratio with heavy drinking?

A

Decreases

31
Q

How does marijuana affect T?

A

disrupts LH and HPA axis
disrupts spermatogenesis
disrupts orgasm, spermatogenesis and orgasm

32
Q

What structural problems does T help reverse?

A

Osteoporosis, sarcopenia

33
Q

What is biggest factor in elevated SHBG?

A

Age

34
Q

What are some hormonal decreases with aging men?

A

T, DHEA by 30
Progesterone by 50
Pregnenolone by 30

35
Q

What are some hormonal increases with aging men?

A 
SHBG
PSA, prostate volume
E2 around age 50
LH, FSH
Prolactin
36
Q

How does estrogen affect DHT?

A

It inhibits DHT metabolism by interfering with hydroxylation

It increases DHT receptors on prostate which inhibits prostate cell apoptosis and increases cell growth

37
Q

What blocks leptin’s signal to brain?

A

TGL

38
Q

What are 3 botanicals for BPH?

A

Rye Grass Pollen,

Pygeum, Stinging nettle(root, not leaf)

39
Q

How does zinc inhibit BPH?

A

Weak 5 a reductase inhibitor
Prevents androgens from binding to DHT receptor
Inhibits prolactin(which like E2, increases DHT receptors on the prostate)

IFM Study (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions