Testicular Tumors Flashcards

1
Q

What are testicular tumor types?

A
  • Germ Cell (90-95%)

- Stromal

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2
Q

Germ cell tumors are separated into what 2 categories?

A
  • Seminoma

- Non seminoma

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3
Q

Stromal tumors are separated into what 3 categories?

A
  • Leydig
  • Sertoli
  • Granulosa
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4
Q

What are RFs for testicular tumors?

A
  • Cryptorchidism
  • Family hx
  • Personal hx
  • HIV
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5
Q

How do testicular tumors present?

A
  • Painless mass or swelling in testicle
  • R > L
  • Back pain or abd mass
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6
Q

What are characteristics of metastatic testicular tumors?

A
  • Bilateral
  • Lymphatic: retroperitoneal lymph nodes
  • Distant: lung, liver, brain, bone, kidney, adrenal, spleen
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7
Q

What are the 3 tumor markers used?

A
  • Alpha-fetoprotein (AFP)
  • Beta-HCG
  • Lactate dehydrogenase (LDH)
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8
Q

What imaging studies are used to dx testicular tumors?

A
  • U/S

- CXR (metastasis?)

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9
Q

What labs are used to dx testicular tumors?

A
  • LFTs
  • CBC
  • Creatinine
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10
Q

Which type of tumors require referral to oncology?

A

Lymphomas

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11
Q

How do you tx testicular tumors?

A

Radical orchiectomy (scrotal or inguinal)

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12
Q

Describe: radical orchiectomy

A
  • outpatient
  • scrotal compression
  • ice pack, elevation, analgesics
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13
Q

How long should you wait to check tumor markers post orchiectomy?

A

Five 1/2 lives

  • AFP: 5 wks
  • B-HCG: 1-2 wks
  • LDH: 3 wks
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14
Q

What imaging should be performed post orchiectomy?

A

CT chest/abd/pelvis

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15
Q

How do you stage testicular tumors?

A

TNM system

  • Tumor: Tx-T4
  • Lymph nodes: Nx-N3
  • Distant met: M0-M1b

S: serum tumor markers post orchiectomy

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16
Q

What are the 5 stages of testicular tumors?

A
  • Stage I
  • Stage IIA
  • Stage IIB
  • Stage IIC
  • Stage III
17
Q

What are the tx options post-orchiectomy?

A
  • Surveillance
  • Chemo
  • Radiation
  • Retroperitoneal Lymph Node Dissection (RPLND)
18
Q

Describe: surveillance post-orchiectomy

A
  • H&P, tumor markers q 3-4mos x 2 yrs

- H&P, tumor markers q 6-12 mos x 2 yrs then annually

19
Q

What is the imaging schedule for surveillance post-orchiectomy?

A
  • CT abd/pelvis q 6mos x 2 yrs

- CT abd/pelvis q 6-12mos x 1 yr, then annually

20
Q

What are side-effects of chemo?

A
  • Myelosuppression
  • Nausea
  • Fatigue
  • Poss infertility
21
Q

What are the acute side effects of radiation?

A
  • Nausea

- Less frequent: vomiting, fatigue, myelosuppression

22
Q

What are the long-term side effects of radiation?

A
  • PUD, gastritis
  • Increased CV risk
  • Increased risk of 2ndary CA