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BMB401 > Test2, Replication and Transcription > Flashcards

Test2, Replication and Transcription Flashcards

Memorize the drugs pertinent to inhibition of replication, transcription, and translational (gene expression) processes

1
Q

What is Psoralen?

A

Upon activation by UV radiation, intercalates across strands of DNA,(2, 2+2 cycloadditions) linking thymines in 5’TpA sequences. Effect: Arrests DNA replication

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2
Q

What is Rifampin

A

Semisynthetic drug derived from a compound isolated from A. rifamycinica. Primarily used in treatment of tuberculosis. Effect: Block prokaryotic transcription after 2-3 ribonucleotides. Binds near bacterial RNAP active site.

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3
Q

Adderall

A

Amphetamine mixture (D/L amphetamine). Adrenergic Receptor Agonist (Stimulant, GPCR agonist)

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4
Q

Benadryl, Zyrtec, Claritin

A

Histamine (H1) Receptor Antagonists (Allergy Relief) (3)

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5
Q

Tagamet, Zantac, Pepsid

A

Histamine (H2) Receptor Antagonists (Stomach acid relief) (3)

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6
Q

Hydrocortisone, cortisone, prednisone, dexamethasone, betamethasone

A

Glucocorticoids, steroids (anti-inflammatory/immunosuppressants) (5)

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7
Q

Iressa, Tarceva, Tykerb

A

EGFR inhibitors; Lung and breast cancer (3)

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8
Q

Jakafi, Xeljanz

A

JAK inhibitors; Myelofibrosis, rheumatoid arthritis (2)

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9
Q

rev

Upon activation by UV radiation, intercalates across strands of DNA,(2, 2+2 cycloadditions) linking thymines in 5’TpA sequences. Effect: Arrests DNA replication

A

What is Psoralen?

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10
Q

rev

Semisynthetic drug derived from a compound isolated from A. rifamycinica. Primarily used in treatment of tuberculosis. Effect: Block prokaryotic transcription after 2-3 ribonucleotides. Binds near bacterial RNAP active site.

A

What is Rifampin

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11
Q

rev

Amphetamine mixture (D/L amphetamine). Adrenergic Receptor Agonist (Stimulant, GPCR agonist)

A

Adderall

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12
Q

rev

Histamine (H1) Receptor Antagonists (Allergy Relief) (3)

A

Benadryl, Zyrtec, Claritin

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13
Q

rev

Histamine (H2) Receptor Antagonists (Stomach acid relief) (3)

A

Tagamet, Zantac, Pepsid

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14
Q

rev

Glucocorticoids, steroids (anti-inflammatory/immunosuppressants) (5)

A

Hydrocortisone, cortisone, prednisone, dexamethasone, betamethasone

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15
Q

rev

EGFR inhibitors; Lung and breast cancer (3)

A

Iressa, Tarceva, Tykerb

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16
Q

rev

JAK inhibitors; Myelofibrosis, rheumatoid arthritis (2)

A

Jakafi, Xeljanz

17
Q

Actinomycin D

A

Eukaryotic transcription arrest

BMB401 (6 decks)

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