Test 4: PACU (pt 3/3) Hypothermia, PONV Flashcards

1
Q

What is the definition of hypothermia?

A

A condition marked by an abnormally low internal body temperature (below 36°C), that occurs when systemic heat loss exceeds heat production.

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2
Q

The greatest amount of heat loss occurs during the _____ hour in the periop setting, and patients in rooms at a temperature of ____ degrees C will all develop hypothermia.

A

Reports suggest that the greatest amount of heat loss occurs during the first hour in the perioperative setting and that patients in rooms at a temperature of 21°C will all develop hypothermia.

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3
Q

What are the 4 Mechanisms for heat loss?

A

Radiation
Evaporation
Convection
Conduction

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4
Q

What is the mechanism responsible for the majority of heat loss?

A

Radiation

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5
Q

What is Radiation Heat Loss?

A

The loss of heat from a warm or hot surface (the body) to a cooler one (the environment).
-It does not require that the two surfaces be in direct contact with each other.
-Accounts for 40% to 60% of heat loss to the environment.
-Especially profound in the elderly, debilitated, and neonatal populations.

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6
Q

What is Convection Heat Loss?

A

-2nd most important contributor
-Convective heat loss depends on the existence of a temperature gradient between the body and the ambient air.
-This type of heat loss may occur in the OR, particularly in laminar flow rooms, and accounts for 25% to 50% of heat loss.

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7
Q

What is Conductive Heat Loss?

A

Loss of heat from a warm surface that comes into contact with a cooler one; it accounts for as much as 10% of heat loss in the OR, where patients lose heat to cooler OR tables, sheets, drapes, skin preparation fluids, and IV fluids or irrigants.

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8
Q

What is Evaporative Heat Loss?

A

Transfer of heat during the change from a liquid to a gas. Evaporative heat loss occurs via perspiration, respiration, or exposed viscera during surgery. Evaporation accounts for as much as 25% of heat loss in the OR.

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9
Q

What are other surgical related factors that cause hypothermia?

A

-Ambient room temperature
-Redistribution of lower-temp blood from the vasodilated, anesthetized periphery to the central compartment also accounts for significant heat loss.
-General and regional anesthesia inhibit thermoregulation and cause significant vasodilation such that temperature monitoring is warranted.
-Opioids and muscle relaxants depress shivering
-Any patient in whom a body cavity is entered will lose heat via convection/evaporation
-Irrigation solutions are cold
-During local anesthesia or sedation, temperature monitoring should be considered under circumstances in which the patient is at risk of hypothermia and should always be immediately available.

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10
Q

General anesthetics depress the _______________ center, with a usual temperature drop of ___°C to ____°C.

A

General anesthetics depress the thermoregulatory center, with a usual temperature drop of 1°C to 3°C.

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11
Q

Warming ____ induction can reduce redistribution hypothermia.

A

BEFORE induction

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12
Q

What are the physiologic consequences of Hypothermia?

A

-Increased O2 consumption 400-500% through shivering
-Increased risk CV events, MI, and sickling with sickle cell dz
-Impaired coagulation and cold-induced defect in platelet function (Increases surgical blood loss → increased transfusion rates)
-Decreased drug metabolism and elimination
-CNS depression
-Discomfort and decreased patient satisfaction
-Impaired wound healing, surgical site infection
-Prolonged PACU stay and increased hospital costs

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13
Q

____ of hypothermia is far superior to ______________________!!!

A

Prevention far superior to active rewarming!!!

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14
Q

What are strategies for Hypothermia Prevention?

A

-Assess every patient of the need for prewarming in preop
-Preoperative cutaneous warming: forced air warming blanket
-Airway heating and humidification (HME): More effective in pediatrics
-Warm IV fluids and fluid warmers (1U PRBC or 1 L crystalloid can decrease temp by 0.25oC )
-Warm ambient OR temperature (> 23oC required to maintain normothermia)
-Cutaneous heating: warm blankets, forced air warming systems

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15
Q

Postoperative nausea and vomiting (PONV) affects ___% to ___% of all surgical patients, and the chance for PONV can be as high as ___ to ___% for high-risk patients.

A

Postoperative nausea and vomiting (PONV) affects 20% to 30% of all surgical patients, and the chance for PONV can be as high as 70% to 80% for high-risk patients.

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16
Q

What are the patient-related factors that increase risk for PONV?

A

-Female gender
-Non-smoker
-Hx PONV/Motion sickness
-Childhood after infancy and younger adulthood

Possible factors:
-PS 1 or 2
-Hx of migraines
-Preop anxiety
-Hx of PONV in 1st degree relative

17
Q

What are the surgery-related factors that increase risk for PONV?

A

-Increased duration of surgery (>3 hrs)
-Dehydration (ensure adequate hydration)

Possible factors:
-Type of surgery (Intra-abd, hernia repair, laparoscopic, gyn, ENT (strabismus), orthopedic)
-NPO status

18
Q

What are the anesthesia-related factors that increase risk for PONV?

A

-Use of Volatile anesthetics/ N2O
-Use of intra and postop opioids

Possible factors:
-Increased duration (>3 hrs)
-Use of GA
-Use of longer acting opioids (morphine)
-Use of Neostigmine for reversal (>2.5 mg)

19
Q

1-2 risk factors is what risk for PONV? How do you prevent it?

A

Moderate-to-severe risk
-Prevention with 2 to 3 drugs from different classes

20
Q

3-4 risk factors is what risk for PONV? How do you prevent it?

A

Severe risk
-Consider avoiding GA or use a propofol-based anesthetic
-Minimize opioids (5)
-Prevention with 3 drugs from different classes

21
Q

What should you do if you cannot avoid GA?

A

-Use TIVA with propofol and opioid adjuncts
-Opioid sparing techniques
-Encourage preop oral intake of clear fluids

22
Q

What medications are utilized in PONV Prophylaxis?

A

-Ondansetron (5HT3 antagonist)
-Metoclopramide (D2 Antagonist in the CTZ)
-Droperidol (D2 Antagonist) - caution with sedation effects up to 12 hrs
-Dexamethasone (suppresses GI peritubular inflammation)
-Scopolamine transdermal (Anti-muscarinic: most useful with motion sickness)
-Pregabalin (reduces need for opioids)

23
Q

What are the intended and adverse effects of Scopolamine?

A

-Acetylcholine muscarinic antagonist
-Crosses the BBB
-Long acting effects (up to 72 hrs): good for PDNV

Adverse effects:
-Sedation
-Dry mouth
-Blurry vision
-Confusion
-Central cholinergic syndrome
-Mydriasis and cycloplegia
-Can worsen narrow-angle glaucoma

24
Q

What are the goals of fluid management during the perioperative period?

A

To maintain adequate intravascular fluid volume, left ventricular filling pressure, cardiac output, systemic blood pressure, and oxygen delivery to tissues.
-Appropriate concentrations of body fluid and electrolytes in the perioperative patient is essential to normal physiologic function of all body systems.

25
Q

What are the symptoms of hypovolemia?

A

-UO can be misleading
-Poor skin perfusion (cool, pale, and clammy skin, particularly in the feet)
-oliguria
-hypotension
-tachycardia
-tachypnea

26
Q

What causes hypovolemia in the periop period?

A

-Failure to replace preoperative fluid deficit and fluid or blood lost during surgery
-Ongoing hemorrhage, sweating, and exudation of fluid into tissues (i.e., third-space losses) in the PACU
-Occult blood loss (RP bleeding)
-Diffuse oozing r/t coagulopathy
-Hemorrhage into muscle after trauma or orthopedic procedures

27
Q

T/F: Hypothermia can mask low intravascular volume.

A

True; In a hypothermic, vasoconstricted patient, a low intravascular volume might maintain cardiac output on PACU admission but cause hypotension when venous capacity increases during rewarming.

28
Q

What is the leading cause of AKI in hospitalized patients?

A

Surgery

29
Q

What are triggers of tubular dysfunction?

A

-hypotension
-hypovolemia
-cardiac dysfunction
-nephrotoxins (meds and contrast dye)
-tissue edema
-fluid overload
-abdominal hypertension
-microvascular dysfunction
-inflammatory-mediated sepsis

30
Q

What are patient risk factors for AKI and Oliguria (<0.5 mL/kg/hr)?

A

-CKD
-obesity/metabolic syndrome
-DM
-CV dz
-hepatobiliary dz
-anemia
-Foley catheter functioning?

31
Q

What provides the greatest protective benefit for kidney function?

A

Maintaining mean arterial pressure within renal autoregulation and administration of appropriate fluid therapy provide the greatest protective benefit.

32
Q

What are the Renal Protective Strategies?

A

1) Correct anemia and minimize blood transfusions
2) Maintain perfusion MAP 80-160mmHg (Autoregulation)
3) Avoid nephrotoxins (aminoglycosides, vanco, contrast)
-If contrast is needed, give N-acetylcysteine and Sodium Bicarb for protection
4) Use balanced crystalloid solutions
-Avoid 0.9% NaCl and HES solutions
5) Avoid diuretics: furosemide and mannitol
6) Continue statin therapy
7) Maintain normoglycemia
8) Consider low-dose dexmedetomidine and sodium bicarbonate infusions
9) Dexamethasone (protective effect)
10) Early initiation renal replacement therapy

33
Q

What meds do you hold preop to prevent AKI?

A

-ACEIs
-ARBs
-NSAIDs
-Diuretics

34
Q

What do PACU orders typically include?

A

-Vital signs & parameters
-Respiratory support (NC, CPAP, nebulizers)
-Fluids
-Analgesics, anxiolytics, antiemetics
-Other PRN medications: antihypertensives, respiratory, insulin
-Laboratory and diagnostic tests (CXR)
-Discharge criteria

35
Q

What is the most commonly used PACU discharge assessment score? What criteria does it use and what is the discharge criteria score?

A

Aldrete;
LOC, Activity, Circulation, Respiratory effort, and Oxygenation
-Discharge criteria is 9-10