Test 4 Flashcards
pharmacodynamic
how the drug affects the body; based upon drug receptor binding
pharmacokinetics
how the body affects the drug
receptor
where a ligand or drug binds initiating an effect
when a binding substance (ligand, hormone, neurotransmitter) interacts with a receptor it can bind because of
typically reversible chemical bonds
binding reaction
rate of association (kon)
unbinding reaction
rate of dissociation (koff)
Kd
the point at which the formation of a drug receptor complex and the dissociation of a drug receptor complex will equal out; point of equilibrium
as ligand concentration increases the concentration of bound receptors will
increase
if the free receptor concentration increases, the concentration of bound receptors will
increase
an increase in concentration of either the ligand or free receptor will result in an
increase drug binding effect
kd
the ligand concentration at which 50% of all available receptors will be bound; expressed as a molar concentration
when L = Kd
a drug will occupy 50% of the receptors present
bound receptors / total receptors
fractional occupancy; the fraction of total receptors that are occupied by a ligand
if L = kd
50% are bound
L > kd
more than 50% of receptors are bound