Test 4 Flashcards

1
Q

pharmacodynamic

A

how the drug affects the body; based upon drug receptor binding

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2
Q

pharmacokinetics

A

how the body affects the drug

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3
Q

receptor

A

where a ligand or drug binds initiating an effect

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4
Q

when a binding substance (ligand, hormone, neurotransmitter) interacts with a receptor it can bind because of

A

typically reversible chemical bonds

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5
Q

binding reaction

A

rate of association (kon)

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6
Q

unbinding reaction

A

rate of dissociation (koff)

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7
Q

Kd

A

the point at which the formation of a drug receptor complex and the dissociation of a drug receptor complex will equal out; point of equilibrium

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8
Q

as ligand concentration increases the concentration of bound receptors will

A

increase

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9
Q

if the free receptor concentration increases, the concentration of bound receptors will

A

increase

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10
Q

an increase in concentration of either the ligand or free receptor will result in an

A

increase drug binding effect

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11
Q

kd

A

the ligand concentration at which 50% of all available receptors will be bound; expressed as a molar concentration

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12
Q

when L = Kd

A

a drug will occupy 50% of the receptors present

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13
Q

bound receptors / total receptors

A

fractional occupancy; the fraction of total receptors that are occupied by a ligand

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14
Q

if L = kd

A

50% are bound

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15
Q

L > kd

A

more than 50% of receptors are bound

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16
Q

L < kd

A

less than 50% of receptors are bound

17
Q

affinity

A

the tendency of a drug to combine with its receptor and is a measure of the strength of the drug receptor bond