TEST 3 STUDY GUIDE EMBRYOLOGY, INFERTILITY, US IN OB Flashcards
____ are derived from primordial germ cells , multiply quickly and w/ degeneration at birth there are 1-2 million.
oogonium
oogonia differentiate into primary oocytes w/ a single layer of granulosa cells from the cortical cord forming the _____ _____; this process remains arrested untill puberty.
primordial Follicles (ovaries)
true or false?the ductus venosus shunts oxygenated blood past the liver into the IVC
true
what is the first system to become functional in the embryo?
cardiovascular
the celiac artery, SMA, and IMA develop from the ______ _____ _____
vitelline artey complex
gestational (postovulatory) age is considered from:
2 weeks from the first day of the LMP
What caries oxygenated blood from the embryonic portion of the placenta to the embryonic tubular heart?
umbilical veins
the pancreas is formed from the ___
foregut
during embryonic life, what is the spleen responsible for?
producing RBC and WBC
the external genitals of male and femaly embryos are undifferentiated until the 8th week of gestation; before that all embryos have a region known as the _____ _____.
genital tubercle
when does neural tube formation take place?
3 to 4 weeks gestation
the liver and pancreas originate in the embryonic ____
duodenum
the _____ & ____ systems develop simultaneously arising from mesoderm on common ridge.
urinary and reproductive
congenital anomalies of the ___ system is highly associated with the ____ system.
urinary; reproductive
the _____ ____ (Woofian duct) develops into the urinary system.
Mesonephric duct (Woofian duct)
true or false? gonadal ridges are formed before the ovaries or testies
true
the ______ _____ (Mullerian duct) developos into the female reproductive system
paramesonephric ducts (Mullerian duct)
The mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Mullerian duct) arise from mesoderm on ____ _____.
common ridges
the female reproductive system development is linked to ___ ___
renal system
what is the formula to calculate pediatric ovarian size?
prolate ellipse formula
L x H x W x 0.523= ___cm3
what is the prolate elipse formula?
measure pediatric ovarian size
prolate elips formula: L x H x W x 0.523= ___ cm3
when do the external genitalia develop by?
12 weeks
no morphologic indication of sex until __ weeks. until this point male and female embryos appear identical
9
what type o sonography outlines vagina to see pelvic mass or complex congenital abnormality?
hydrosonovaginography
what is the measurement of the bladders smooth thin wall when full or partial full?
< 3 mm if full or <5 mm if partial full
what should we look for when imaging the bladder and how do we angle the transducer?
look for bilateral ureteral jets
angle transducer cauded to view bladder neck and urethra
what do we look for post void of urinary bladder?
check for urinary residual, or to seperate cyst from bladder
what is the newborn uterus measurements and what does it look like?
- prominent 3.5 cm thickened, bright echogenic endometrial lining
- teardrop shape (inverse pear) shape until 2-3 months old
what is the measurement of the prepubertal uterus and what shape is it?
prepubertal uterus:
- 2.5-3 cm length
- fundus to cx ratio decreases to 1:1
- inverse pear shape
- endometrial stripe not visualized (because endometrium doesnt thicken until period starts)
what supples the uterus with blood?
uterine arteries branch off internal iliac arteries
true or false? it is possible to see flow in myometrial tissue w/ no flow in endometrium
true
how is the vagina best visualized?
on midline longitudinal image TA
what does the vagina look like sonographically?
- tubular structure behind bladder continuous with cervix
- mucosal wall cause bright echo within tubular structure
what is the best way to measure ovarian size?
ovarian volume using the prolate-ellipse formula:
L x H x W x 0.523 = ___ cm3
what supplies the ovaries w/ blood
blood supply from the ovarian artery originating from aorta and uterine artery
approximately 0.5% of femal patients have ____ uternine anomalies. ___ ____ abnormalites are about 50% of the total number.
congenital
urinary tract
what are some congenital anomalies associated with?
spontaneous abortion, and obstetric complications
what is the most comon genital anomaly detected in utero?
hydrometrocolpos (fluid filled vagina and uterus)
true or false? hydrometrocolpos can sometimes compress urinary tract to cause hydronephrosis or hydroureter
true
hydrometrocolpos
fluid filled uterus (metro) and vagina (colpos)
what are the 6 types of Mullerian anomalies?
- incomplete vaginal canalization (segmental mullerian agenesis)
- unicornuate uterus
- uterus didelphys
- bicornuate uterus (best trans)
- septate uterus
- DES exposure in utero
the ___ portion of the paramesonephric (Mullerian) duct fuses and develops into the uterus and part of the vagina
caudal
the ____ parts of the paramesonephric (Mullerian )ducts form the uterine tubees
cranial
what forms most of the female genital tract?
paramesonephric (Mullerian duct)
what causes the newborn female uterus to appear prominent with thickened hyperechooic endometrial lining?
hormonal stimulation received in utero
prepubertal size of the uterus demonstrates a fundus:cx ratio of what?
1:1
congenital anomalies of the uterus have a high association with ___ anomalies
renal
hydrocolpos
fluid filled vagina
bicornuate uterus
duplication of the uterus w/ a common cervix
- low incidence of infertility
- best seen in trans
- rudimentary horn may cause complications
unicornuate uterus demonstrates:
uterus is small and laterally positioned
- infertility and pregnmancy loss
- renal agenesis contralateral side
- uterus long and slender
- difficult to differentiate from normal
- deviated long, slender (ex cigar) uterine shape
didelphys uterus demonstrates:
complete duplication of the uterus, cervix, and vagina
- complete duplication
- does not usually require tmt
- 2 endometrial complexes
what causes vaginal atresia and how is it diagnosed?
- cause: segmental agenesis or incomplete canalization of the vagina.
- Diagnosed by: development of fluid or blood in the uterus and cervix (hydrocolpos, hydrometrocolpos, or hematometrocolpos)
septate uterus demonstrates:
2 closely spaced uterine cavities w/ 1 fundus and 2 cervical canals or vaginal septum
- high incidence of fertility problems
- septum can be removed by hysteroscope
____ _____ has the highest incidence of fertility problems; the septum may be removed hysteroscopically
septate uterus
segmental mullerian agenesis ( incomplete vaginal canalization) appearance:
- produces transverse vaginal septum or vaginal atresia
- Dx by dev of hydrocolpos, hydrometrocolpos or hematometrocolpos
- Cx may by absent w/ or w/o blood in uterus or cx
- in neonatal -large cystic pelvic/abd mass bec. maternal sim or it is sen at puberty
- may also be caused by imperforate hymen
unicornuate uterus appears:
- renal agenisis on contralateral side
- uteus long & slender (ex cigar), small and positioned laterally
- hard to tell from normal
infertility and pregnancy loss
uterus didelphys appears:
complete duplication w/ 2 endometrial compleses
(doesnt urually require treatment
bicornuate uterus appears:
duplication w/ common cervix
best seen in trans
low incidence of infertility
rudimentary horn may cause problems
septate uterus appears:
(we dont usually see this because it is very thin)
2 uterine cavities closely spaced w/ 1 fundus and 2 cervical canals or vaginal septum
**highest incidence of infertility**
septum can be removed w/ hysteroscope
DES exposure in utero appearance:
normal uterus w/ t-shaped endometrial cavity
causes vag malignancies-
their mothers took DES in 70s due to risk of abortion
difficult to diagnose w/ US
the most common cause of female pseudohermaphroditism is:
a congenital virilizing adrenal hyperplasia.
an increase in androgens leads to masculinization
true or false? Mullerian abnormalities include improper fusion, incomplete development of one side, and incomplete vaginal canalization.
true
what is percocious puberty?
onset of normal physiologic and endocrine processes of puberty in girls before age 8.
- must have all 3 signs (breast dev., pubic and axillary hair, menstruation)
causes of precocious puberty
- idiopathic 80% secondary to eary activation of hypothalmic-pituitary-gonadal axis
- may be related to CNS lesion tht effects hypothalmus
- 20% 2o to causes other than pit axis= pseudoprecocious
precocious puberty sonographic appearance:
- adult configured uterus
- symetric ovarian enlargement *VERIFIES true precocious puberty
precocious puberty treatment
hormone replacement therapy w/ US follow ups to monitor size and volume changes
pseudoprecocious puberty definition and causes
- incomplete precocious puberty
- do not have all 3 signs
- **breast development, axillary and pubic hair, menstruation**
- do not have all 3 signs
- hormone secretion from pathology other than hypothalmic-pituitary-axis
- CAUSES: enchphalitis; hypothyroidism, mccune albright syndrome, ovarian neoplasm , brain tumor
pseudoprecocious puberty sonographic findings:
- infantile uterus and ovaries
- if infantile uterus and asymetrical enlarged ovaries, suggest ovarian pathology
- usually CT or MRI of adrenal and hypothalmic region
Neonatal Cysts appearance
typical ovary heterogeneous & cystic
Most cysts < 9mm resolve spontaneously
Cysts >2 cm; pathology
true or false? neonatal cysts have a higher incidence w/ babies whos mothers had toxemia, diabetes, and Rh isoimmunization, hypothyroidism
true
appearance & complications of neonatal cysts
- complications: hemorrhage, salpingotorsion
- appearance
- various size
- simple
- or hemorrhagic w/ internal exhoes
- may be caued by torsion
- may see hemorrhagic ascites and/or peritonitis (free fluid)
- may compress other organs
ovarian torsion facts
- usually occur w/in first 2 decades of life
- rt side 3x more likely to torse than left (less space on left due to gut)
- s/s: severe onset abd pain
- Sonographic: enlarged ovary, fluid in cul de sac, or tumor
- Color doppler: variable
Ovarian teratomas are uncomon in neonate and adolescents
- ___ ____ tumors 60% of ovarian neoplams in pt < age 20
germ cell
what is the most common benign pediatric germ cell tumor?
benign mature teratoma or dermoid cyst
benign mature teratoma or dermoid cyst appearance & complication:
- size: 5-15 cm
- multiple appearance
- most common complication: torsion (16-40%)