Test 3 BOok

Question 1

Exploratory vs validating cohort

Answer 1

Exp - assess whether certain lab vlaue can make dx

Validating - Assess performance of a single cut-off value

Question 2

Most appropriate cutoff

Answer 2

Maximize true positives and minimize number of false positives

Question 3

Verification bias

Answer 3

If results of diagnostic test are used to determine whether a gold standard test is necessary…this is when gold standard test is invasive, risky or expensive

Question 4

Harms from screeninig tests

Answer 4

False neg - if pt develops morbidity from dz going undetected

False positive - subject pt to unnecessary dx testing and potentiall unnecessary tx

True pos - overdiagnsosis

Question 5

Length bias

Answer 5

More slowly progressing cases found vs. rapidly progressing cases