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GI Pharmacology > Test 3 > Flashcards

Test 3 Flashcards

1
Q

Levothyroxine MOA

A

Synthetic thyroxine binds to the T4 receptor and imitates the reaction of T4

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2
Q

Levothyroxine Class

A

Thyroid hormone analog

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3
Q

Levothyroxine indications

A

Hypothyroidism and pituitary TSH suppression

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4
Q

Methimazole MOA

A

Inhibits oxidation of iodine in the thyroid gland, preventing T3 and T4 formation

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5
Q

Methimazole Class

A

Thiomide, Anti-Thyroid Agent

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6
Q

Methimazole indications

A

Hyperthyroidism and Graves’ disease

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7
Q

Propylthiouracil MOA

A

Inhibits oxidation of iodine in the thyroid gland, preventing T3 and T4 formation

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8
Q

Propylthiouracil Class

A

Thiomide, Anti-Thyroid Agent

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9
Q

Propylthiouracil indications

A

Hyperthyroidism and Graves’ disease

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10
Q

Propanolol MOA

A

Competitively blocks beta-adrenergic receptors

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11
Q

Propanolol Class

A

Non-specific beta-blocker

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12
Q

Propanolol Indicaitons

A

Thyrotoxicosis, thyroid storm

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13
Q

Iodine-131 MOA

A

Radiologically destroys the thryoid gland tissue through beta particle emission

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14
Q

Iodine-131 Class

A

Radiopharmaceutical antithyroid agent

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15
Q

Iodine-131 Indications

A

Hyperthyroidism, imaging modality

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16
Q

Bisphosphonates MOA

A

Binds to bone tissue and prevents osteoclast degradation

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17
Q

Bisphosphonates Class

A

Antiosteoporotic agent

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18
Q

Bisphosphonates Indications

A

Osteoporosis, Paget’s disease

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19
Q

Calcitonin MOA

A

Antagonizes effects of PTH inhibiting osteoclast bone resorption, increases renal excretion of phosphate and calcium

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20
Q

Calcitonin Class

A

Hormone

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21
Q

Calcitonin Indications

A

Osteoporosis, Paget’s disease, hypercalcemia

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22
Q

Calcitriol MOA

A

Activates vitamin D receptors to increase serum calcium and decrease PTH levels

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23
Q

Calcitriol Class

A

Vitamin D analog

24
Q

Calcitriol Indications

A

Hypocalcemia, hyperparathyroidism, chronic kidney disease

25
Q

Cinacalcet MOA

A

Increases sensitivity of the CaSR on the parathyroid gland, loweing serum calcium and phosphate

26
Q

Cinacalcet Class

A

Calcimimetic

27
Q

Cinacalcet Indications

A

Secondary hyperparathyroidism, hypercalcemia

28
Q

Hydrochlorothiazone MOA

A

Inhibits sodium and potassium reabsorption in distal tubules

29
Q

Hydrochlorothiazone Class

A

Antihypertensive diuretic

30
Q

Hydrochlorothiazone Indications

A

Corticosteroid and estrogen therapy

31
Q

Cortisol MOA

A

Stimulates glucocorticoid receptors on various tissues

32
Q

Cortisol Class

A

Corticosteroid

33
Q

Cortisol Indications

A

Inflammation, glucocorticoid insufficiency

34
Q

Prednisolone MOA

A

Glucocorticoid analog

35
Q

Prednisolone Class

A

Corticosteroid

36
Q

Prednisolone Indications

A

High glucocorticoid, low mineralocorticoid use

37
Q

Fludrocortisone MOA

A

Mineralocorticoid analog

38
Q

Fludrocortisone Class

A

Corticosteroid

39
Q

Fludrocortisone Indications

A

Low glucocorticoid, high mineralocorticoid use

40
Q

Dexamethasone MOA

A

Glucocorticoid analog

41
Q

Dexamethasone Class

A

Corticosteroid

42
Q

Dexamethasone Indications

A

Glucocorticoid insufficiency

43
Q

Metyrapone MOA

A

Inhibits production of cortisol and increases urine output of cortisol precursor metabolites

44
Q

Metyrapone Class

A

Glucocorticoid blocker

45
Q

Metyrapone Indications

A

Hypothalamic-pituitary ACTH function measurement, Cushing’s syndrome treatment

46
Q

ACTH MOA

A

Acts on the various components of the adrenal medulla to increase overall production of various hormones produced therein

47
Q

ACTH Class

A

Adrenal steroid activator

48
Q

ACTH Indication

A

ACTH insufficiency

49
Q

Mifepristone MOA

A

Synthetic steroid competitively binding to intracellular progesterone and glucocorticoid receptors

50
Q

Mifepristone Class

A

Hormone receptor blocker

51
Q

Mifepristone Indications

A

Hypercortisolism, Cushing’s syndrome, abortion

52
Q

Ketoconazole MOA

A

Inhibits formation of testosterone and cortisol

53
Q

Ketoconazole Class

A

Antiandrogenic, anti-glucocorticoid

54
Q

Ketoconazole Indications

A

Glucocorticoid suppression, Cushing’s syndrome, prostate cancer

55
Q

Spironolactone MOA

A

Competitive antagonist of aldosterone in distal tubules and arteriolar smooth muscles

56
Q

Spironolactone Class

A

Aldosterone blocker

57
Q

Spironolactone Indications

A

Mineralocorticoid suppression, hyperaldosteronism

GI Pharmacology (3 decks)

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