Motility Drugs Flashcards
Class of Botulism Toxin
Neuromuscular blocker, Toxin
Common Name of Botulism Toxin
Botox
MOA of Botox/Botulism Toxin
Inhibits ACh release from the presynaptic surface – reducing neuromuscular transmission/muscular activity
GI Indication for Botox
LES/Internal/Anal Sphincter Achalasia
ADR for Botox
Dysuria, Dsphagia, Constipation, headache, fever, sweating
Class of Promethizine
phenothiazines, antiemetic
Common Name of Promethizine
Phenergan
MOA of Promethizine
Acts on the CNS, muscarininc blocking
GI Indication for Promethizine
vomiting
ADR for Promethizine
drowsiness, confusion, anxiety
Class of Prochlorperazine
antiemetic, phenothiazines
Common Name of Prochlorperazine
Compazine
MOA of Prochlorperazine
Acts on the CNS, D2 dopamine receptor antagonist
GI Indication for Prochlorperazine
Vomiting, nausea, vertigo
ADR for Prochlorperazine
drowsiness, confusion, anxiety
Class of Metoclopramide
Antiemetic, dopamine antagonist
Class of Ondansetron
Antiemetic
Class of Nifedipine
Calcium Channel Blocker (CCB)
Class of Neostigmine
Acetylcholinesterase Inhibitor
Class of Verapamil
Calcium Channel Blocker (CCB)
Common Name of Metoclopramide
Reglan
Common Name of Ondansetron
Zofran
Common Name of Nifedipine
Nifedicep
Common Name of Neostigmine
Prostigmine
Common Name of Verapamil
calan
MOA of Metoclopramide
Acts on CNS and ANS, stimulates gastric peristalsis to facilitate gastric emptying, tightens LES to prevent reflux
MOA of Ondansetron
5-HT3 seretonin receptor antagonist, peripherally and at vagal nerve terminals
MOA of Nifedipine
inhibits calcium form enter the slow channels or voltage sensitive areas of smooth muscle
MOA of Neostigmine
prevents ACh destruction by Aceytlcholinesteras
MOA of Verapamil
inhibits calcium form enter the slow channels or voltage sensitive areas of smooth muscle
GI Indication for Metoclopramide
gastroparesis, gastric stasis, vomiting, particularly due to gastric dysmotility
GI Indication for Ondansetron
nausea and vomiting in pt on chemo
GI Indication for Nifedipine
Esophageal and internal anal sphincter achalasia
GI Indication for Neostigmine
increases bowel motility in the LGI
GI Indication for Verapamil
Esophageal and internal anal sphincter achalasia
ADR for Metoclopramide
restlessness, functional dystonia, tardive dyskinesia
ADR for Ondansetron
headache, malaise, fatigue, constipation
ADR for Nifedipine
flushing, edema, dizziness, headache, nausea, heartburn, constipation