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GI Pharmacology > Motility Drugs > Flashcards

Motility Drugs Flashcards

1
Q

Class of Botulism Toxin

A

Neuromuscular blocker, Toxin

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2
Q

Common Name of Botulism Toxin

A

Botox

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3
Q

MOA of Botox/Botulism Toxin

A

Inhibits ACh release from the presynaptic surface – reducing neuromuscular transmission/muscular activity

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4
Q

GI Indication for Botox

A

LES/Internal/Anal Sphincter Achalasia

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5
Q

ADR for Botox

A

Dysuria, Dsphagia, Constipation, headache, fever, sweating

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6
Q

Class of Promethizine

A

phenothiazines, antiemetic

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7
Q

Common Name of Promethizine

A

Phenergan

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8
Q

MOA of Promethizine

A

Acts on the CNS, muscarininc blocking

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9
Q

GI Indication for Promethizine

A

vomiting

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10
Q

ADR for Promethizine

A

drowsiness, confusion, anxiety

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11
Q

Class of Prochlorperazine

A

antiemetic, phenothiazines

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12
Q

Common Name of Prochlorperazine

A

Compazine

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13
Q

MOA of Prochlorperazine

A

Acts on the CNS, D2 dopamine receptor antagonist

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14
Q

GI Indication for Prochlorperazine

A

Vomiting, nausea, vertigo

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15
Q

ADR for Prochlorperazine

A

drowsiness, confusion, anxiety

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16
Q

Class of Metoclopramide

A

Antiemetic, dopamine antagonist

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17
Q

Class of Ondansetron

A

Antiemetic

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18
Q

Class of Nifedipine

A

Calcium Channel Blocker (CCB)

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19
Q

Class of Neostigmine

A

Acetylcholinesterase Inhibitor

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20
Q

Class of Verapamil

A

Calcium Channel Blocker (CCB)

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21
Q

Common Name of Metoclopramide

A

Reglan

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22
Q

Common Name of Ondansetron

A

Zofran

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23
Q

Common Name of Nifedipine

A

Nifedicep

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24
Q

Common Name of Neostigmine

A

Prostigmine

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25
Q

Common Name of Verapamil

A

calan

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26
Q

MOA of Metoclopramide

A

Acts on CNS and ANS, stimulates gastric peristalsis to facilitate gastric emptying, tightens LES to prevent reflux

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27
Q

MOA of Ondansetron

A

5-HT3 seretonin receptor antagonist, peripherally and at vagal nerve terminals

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28
Q

MOA of Nifedipine

A

inhibits calcium form enter the slow channels or voltage sensitive areas of smooth muscle

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29
Q

MOA of Neostigmine

A

prevents ACh destruction by Aceytlcholinesteras

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30
Q

MOA of Verapamil

A

inhibits calcium form enter the slow channels or voltage sensitive areas of smooth muscle

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31
Q

GI Indication for Metoclopramide

A

gastroparesis, gastric stasis, vomiting, particularly due to gastric dysmotility

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32
Q

GI Indication for Ondansetron

A

nausea and vomiting in pt on chemo

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33
Q

GI Indication for Nifedipine

A

Esophageal and internal anal sphincter achalasia

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34
Q

GI Indication for Neostigmine

A

increases bowel motility in the LGI

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35
Q

GI Indication for Verapamil

A

Esophageal and internal anal sphincter achalasia

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36
Q

ADR for Metoclopramide

A

restlessness, functional dystonia, tardive dyskinesia

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37
Q

ADR for Ondansetron

A

headache, malaise, fatigue, constipation

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38
Q

ADR for Nifedipine

A

flushing, edema, dizziness, headache, nausea, heartburn, constipation

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39
Q

ADR for Neostigmine

A

arrythmia,cardiac arrest, tachycardia, convolsion, dizziness, diarrhea, dysphagia, flatulence, hyperperistalsis, nausea

40
Q

ADR for Verapamil

A

flushing, edema, dizziness, headache, nausea, heartburn, constipation

41
Q

CCBs

A

Verapamil, Nifedipine

42
Q

antiemetic’s

A 
Promethizine (Phenergan)
Prochlorperazine (Compazine)
Metoclopramide (Reglan)
Diphenhydramine (Benadryl)
Ondansetron (Zofran)
43
Q

Class of Diphenhydramine

A

antiemetic. Antihistamines, ethanolamines

44
Q

Class of Maclizine

A

Antiemetic, antihistamine

45
Q

Class of Bethanechol

A

Cholinergic Agonist

46
Q

Class of Al-Mg Antacids

47
Q

Class of Cimetidine

A

H2 receptor antagonist, antacid

48
Q

Class of Ranitidine

A

H2 receptor antagonist, antacid

49
Q

Class of Misoprostil

A

PGE2 receptor stimulator, cytoprotective agen

50
Q

Class of Sucralfate

A

cytoprotective agent,

51
Q

Class of Omeprazole

A

PPI, general GI wonderdrug

52
Q

Class of Lansoprazole

A

PPI, general GI wonderdrug

53
Q

Class of Esomeprazole

A

PPI, general GI wonderdrug

54
Q

Common Name of Diphenhydramine

55
Q

Common Name of Bethanechol

A

Urecholine

56
Q

Common Name of Al-Mg Antacids

A

Mylanta, Maalox is actually Ca2CO3

57
Q

Common Name of Cimetidine

58
Q

Common Name of Ranitidine

59
Q

Common Name of Misoprostil

60
Q

Common Name of Sucralfate

A

(Carafate)

61
Q

Common Name of Omeprazole

A

(Prilosec)

62
Q

Common Name of Lansoprazole

A

(Prevacid)

63
Q

MOA of Diphenhydramine

A

Acts on the CNS, an H1 histamine receptor antagonist

64
Q

MOA of Maclizine

A

central anticholinergic action by blocking chemoreceptor trigger zone; decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways

65
Q

MOA of Bethanechol

A

stimulation of the parasympathetic nervous system, stimulates gastric motility, increases gastric tone, stimulates peristalsis

66
Q

MOA of Al-Mg Antacids

A

neutralizes intestinal acid, forms Al (Cl)3 salt + H2O or MgCl2

67
Q

MOA of Cimetidine

A

Competitive inhibition of histamine at H2 receptors of the gastric parietal cells resulting in reduced gastric acid secretion, gastric volume and hydrogen ion concentration reduced

68
Q

MOA of Ranitidine

A

Competitive inhibition of histamine at H2 receptors of the gastric parietal cells resulting in reduced gastric acid secretion, gastric volume and hydrogen ion concentration reduced

69
Q

MOA of Misoprostil

A

stimulates PGE2 receptors, resulting in inhibition of acid secretion and stimulation of mucus and bicarbonate production.

70
Q

MOA of Sucralfate

A

binds with positively charged protein exudates to form a viscous paste that creates a protective coating in the stomach. Does not alter stomach flora by changing chemical composition.

71
Q

MOA of Omeprazole

A

selectively inhibit the Hydrogen/Potassium ATPase pump on the pareital cell apical surface. Inhibits both stimulated and basal gastric H+ secretion.

72
Q

MOA of Lansoprazole

A

selectively inhibit the Hydrogen/Potassium ATPase pump on the pareital cell apical surface. Inhibits both stimulated and basal gastric H+ secretion.

73
Q

MOA of Esomeprazole

A

selectively inhibit the Hydrogen/Potassium ATPase pump on the pareital cell apical surface. Inhibits both stimulated and basal gastric H+ secretion.

74
Q

GI Indication for Diphenhydramine

75
Q

GI Indication for Maclizine

A

nausea related to vertigo and motion sickness

76
Q

GI Indication for Bethanechol

A

GERD, to increase UGI motility

77
Q

GI Indication for Al-Mg Antacids

A

PUD and GERD, mainly sx relief

78
Q

GI Indication for Cimetidine

A

duodenal and gastric ulcers (speed healing, reduce sx), gastric hypersecretion, GERD, part of H. pylori multidrug therapy

79
Q

GI Indication for Ranitidine

A

duodenal and gastric ulcers (speed healing, reduce sx), gastric hypersecretion, GERD, part of H. pylori multidrug therapy

80
Q

GI Indication for Misoprostil

A

prevention of gastric ulcers, especially w NSAID use

81
Q

GI Indication for Sucralfate

A

short term management of ulcers

82
Q

GI Indication for Omeprazole

A

GERD, PUD, H. pylori, Zollinger-Ellison syndrome, erosive esophagitis

83
Q

GI Indication for Lansoprazole

A

GERD, PUD, H. pylori, Zollinger-Ellison syndrome, erosive esophagitis

84
Q

GI Indication for Esomeprazole

A

GERD, PUD, H. pylori, Zollinger-Ellison syndrome, erosive esophagitis

85
Q

ADR for Diphenhydramine

A

drowsiness, confusion, anxiety

86
Q

ADR for Maclizine

A

drowsiness, fatigue, headache, vomiting, blurred vision, anaphylaxis

87
Q

ADR for Bethanechol

A

hypotension, tachycardia, headache, abdominal cramps, belching, borborygmi, diarrhea, colicky pain, nausea, vomiting

88
Q

ADR for Al-Mg Antacids

A

Al - constipation, Mg - diarrhea

89
Q

ADR for Cimetidine

A

diarrhea, nausea, vomiting, anaphylaxis, headache, dizziness, bradycardia, tachycardia (what?!), vasculits, there are more and im done typing

90
Q

ADR for Ranitidine

A

abdominal discomfort or pain, constipation, diarrhea, nausea, vomiting, agitation, dizziness, headache

91
Q

ADR for Misoprostil

A

Constipation, dyspepsia, flatulence, nausea, vomiting, headache

92
Q

ADR for Sucralfate

A

constipation

93
Q

ADR for Omeprazole

A

abdominal pain, diarrhea, nausea, vomiting, headache, dizziness, rash

94
Q

ADR for Lansoprazole

A

abdominal pain, diarrhea, nausea, vomiting, headache, dizziness, rash

95
Q

ADR for Esomeprazole

A

abdominal pain, diarrhea, nausea, vomiting, headache, dizziness, rash

96
Q

Common Name of Esomeprazole

GI Pharmacology (3 decks)

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