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neuropharmacology test 2 > test 2 lec 3 > Flashcards

test 2 lec 3 Flashcards

1
Q

test 2 lec 3

name 4 different type of VDKC

A

Ia, Id,Ik,Im

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2
Q

test 2 lec 3

which one of the VDKC are LVA?

A

Ia, Id,Im

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3
Q

test 2 lec 3

which VDKC activate and inactivate rapidly?

A

Ia

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4
Q

test 2 lec 3

which one of the VDKC is medium inactivating?

A

Id

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5
Q

test 2 lec 3

which on of the VDKC is activated while the Na+ channels are activated?

A

Ia,Id

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6
Q

test 2 lec 3

which one of the VDKC is considerd HVA? It is slow of fast inactivating?

A

Ik, slow inactivating

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7
Q

test 2 lec 3

how long does Ik stay active?

A

as long as the membrane potential is strongly depolarized,

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8
Q

test 2 lec 3

what is the function of Ik?

A

to bring the membrane potential back down in the resting potential taneg

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9
Q

test 2 lec 3

how does Ik inactivate?

A

they help create condition that inactivate them , by bringing the membrane potentail near resting potential

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10
Q

test 2 lec 3

which one of the VDKC in considered non-inactivating?

A

Im

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11
Q

test 2 lec 3

which one of the VDKC is not inactivated by voltage change?

A

Im

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12
Q

test 2 lec 3

which is the effect of voltage on Ik after its being activated?

A

nothing

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13
Q

test 2 lec 3

which ion can block all kinds of VDKC?

A

Cs

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14
Q

test 2 lec 3

which of the VDKC are blcoked by DTX?

A

Ia, Id, Ik

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15
Q

test 2 lec 3

which one of the VDKC is activated by Retigabine?

A

Ia and Im

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16
Q

test 2 lec 3

which is the ingridient that help reverse male-pattern baldness and what does it do?

A

Minoxidil and it activates the Id VDKC

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17
Q

test 2 lec 3

which one of the VDKC are activated by adding a sugar to the extracellular side of it?

A

Ik,

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18
Q

test 2 lec 3

how is Ik activated

A

by Glycosylation

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19
Q

test 2 lec 3

which one of the VDKC is not blocked by DTX?

A

Im

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20
Q

test 2 lec 3

which one of the VDKC is blocked by DTX?

A

Ia,Id,Ik

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21
Q

test 2 lec 3

which scorpian toxin blocks VDKC Ia,Id,Ik?

A

DTX (dendrotoxin)

22
Q

test 2 lec 3

which drug blocks the fast , slow and medium inactivation VDKC?

A

TEA, 4-AP (4-aminoperidine)

23
Q

test 2 lec 3

which VDKC is blocked by TEA?

A

Ia,Id,Ik

24
Q

test 2 lec 3

which drug can activate Id?

A

Minoxidil

25
Q

test 2 lec 3

what drug can activate Ia and Im?

A

retigabine

26
Q

test 2 lec 3

what are the 2 drug that only blockes Im?

A

Linopiridine, muscarinic agonist

27
Q

test 2 lec 3

which potassium channel is HVA and SI?

A

Ik

28
Q

test 2 lec 3

whatmechanism is responsible for activation of VDKC?

A

Voltage-dependent conformational movement of negatively charged portions of the alpha subunits activate K influx

29
Q

test 2 lec 3

which subunit of VDKC is responsible for the K influx?

A

alpha subunit

30
Q

test 2 lec 3

which subunit is responsible for inactivation of VDKC?

A

Beta subunit which is inside the membrane

31
Q

test 2 lec 3

how does B-subunit blockes the VDKC?

A

Inactivation involves voltage-dependent binding of any 1 of 4 positively charged ball and chain portions of beta subunits to block K influx

32
Q

test 2 lec 3

which one of the VDKC lacks B-subunit?

A

Im which is the non-inactivating one

33
Q

test 2 lec 3

why is Im VDKC in called non-inactivating?

A

because it lacks B-subunit

34
Q

test 2 lec 3

what is the Anomalous and Ih rectifier K channel made of?

A

4 seperated subunit with 2 Transmembrane segment each

35
Q

test 2 lec 3

what is the structural difference of the tandom channel eith other VDKC?

A

4 different sets of subunits with 4 transmembrane segments each, dimerize (2 sets of 4) to yield a single protein with 2 pores

36
Q

test 2 lec 3

which potassium channel is considered both rectifying and VDKC?

A

Ik

37
Q

test 2 lec 3

how does Ik activates?

A

activate when membrane is depolarized, and it is a HVA channel

38
Q

test 2 lec 3

which one of the Rectifying channel is Slow inactivating?

A

all of them, Ik, HA and Anomalous, Ih, tandom pore

39
Q

test 2 lec 3

which one of the Rectifying channel has no known blocker?

A

Tandom pore

40
Q

test 2 lec 3

how does anomalous and IH channels are activated?

A

they are hyperpolarization activated

41
Q

test 2 lec 3

what does anomalous and Ih channel do to the membrane potential?

A

they bring the membrane back to the resting potential by generating the inward K+ current

42
Q

test 2 lec 3

how does the 2 activators of Tandom pore?

A

Halothane and Isoflurane, they recryfie the membrane potential, they bring it down to resting potential
,explain how local anesthetics work

43
Q

test 2 lec 3

does changing the membrane voltage affect the activation of tandom pore?

A

no

44
Q

test 2 lec 3

what is the effect of voltage change on tandom pore?

A

They are not affected by voltage

45
Q

test 2 lec 3

what is the side effect of the chronic exposure to the Halothane?

A

they cause sever liver damage to the people who is in operating room that is exposed in daily bases

46
Q

test 2 lec 3

what decreases the current flow in Metabotropic-gated channels ?

A

kinase’s activity (phosphorylation) decrease theoutward current to Metabotropic-gated channels

47
Q

test 2 lec 3

what process can increase the current flow of Metabotropic-gated channels ?

A

phosphatases can increase the current flow to thoes channels.

48
Q

test 2 lec 3

what are the four types of Metabotropic-gated channels?

A

Im,Iatp,Iahp,Isahp

49
Q

test 2 lec 3

Metabotropic-gated channels are activated by:

A

they tight to ion channel which are activated indirectly by binding of ligand to receptor and binding of inactive G-protein to thoes receptor and then the exchange of GTP for GDP then the dissociation of alpha and beta-gamma subunit then _.. Read the process of G-protein life cycle

50
Q

test 2 lec 3

what kinase is activated by CAMP?

A

PKA, it takes 4 CAMP to fully activates it, then that kinase can phosphorylate protein including these channels and inactivate them and decrease the flow of current.

neuropharmacology test 2 (8 decks)

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