test 2 lec 3 Flashcards
test 2 lec 3
name 4 different type of VDKC
Ia, Id,Ik,Im
test 2 lec 3
which one of the VDKC are LVA?
Ia, Id,Im
test 2 lec 3
which VDKC activate and inactivate rapidly?
Ia
test 2 lec 3
which one of the VDKC is medium inactivating?
Id
test 2 lec 3
which on of the VDKC is activated while the Na+ channels are activated?
Ia,Id
test 2 lec 3
which one of the VDKC is considerd HVA? It is slow of fast inactivating?
Ik, slow inactivating
test 2 lec 3
how long does Ik stay active?
as long as the membrane potential is strongly depolarized,
test 2 lec 3
what is the function of Ik?
to bring the membrane potential back down in the resting potential taneg
test 2 lec 3
how does Ik inactivate?
they help create condition that inactivate them , by bringing the membrane potentail near resting potential
test 2 lec 3
which one of the VDKC in considered non-inactivating?
Im
test 2 lec 3
which one of the VDKC is not inactivated by voltage change?
Im
test 2 lec 3
which is the effect of voltage on Ik after its being activated?
nothing
test 2 lec 3
which ion can block all kinds of VDKC?
Cs
test 2 lec 3
which of the VDKC are blcoked by DTX?
Ia, Id, Ik
test 2 lec 3
which one of the VDKC is activated by Retigabine?
Ia and Im
test 2 lec 3
which is the ingridient that help reverse male-pattern baldness and what does it do?
Minoxidil and it activates the Id VDKC
test 2 lec 3
which one of the VDKC are activated by adding a sugar to the extracellular side of it?
Ik,
test 2 lec 3
how is Ik activated
by Glycosylation
test 2 lec 3
which one of the VDKC is not blocked by DTX?
Im
test 2 lec 3
which one of the VDKC is blocked by DTX?
Ia,Id,Ik
test 2 lec 3
which scorpian toxin blocks VDKC Ia,Id,Ik?
DTX (dendrotoxin)
test 2 lec 3
which drug blocks the fast , slow and medium inactivation VDKC?
TEA, 4-AP (4-aminoperidine)
test 2 lec 3
which VDKC is blocked by TEA?
Ia,Id,Ik
test 2 lec 3
which drug can activate Id?
Minoxidil
test 2 lec 3
what drug can activate Ia and Im?
retigabine
test 2 lec 3
what are the 2 drug that only blockes Im?
Linopiridine, muscarinic agonist
test 2 lec 3
which potassium channel is HVA and SI?
Ik
test 2 lec 3
whatmechanism is responsible for activation of VDKC?
Voltage-dependent conformational movement of negatively charged portions of the alpha subunits activate K influx
test 2 lec 3
which subunit of VDKC is responsible for the K influx?
alpha subunit
test 2 lec 3
which subunit is responsible for inactivation of VDKC?
Beta subunit which is inside the membrane
test 2 lec 3
how does B-subunit blockes the VDKC?
Inactivation involves voltage-dependent binding of any 1 of 4 positively charged ball and chain portions of beta subunits to block K influx
test 2 lec 3
which one of the VDKC lacks B-subunit?
Im which is the non-inactivating one
test 2 lec 3
why is Im VDKC in called non-inactivating?
because it lacks B-subunit
test 2 lec 3
what is the Anomalous and Ih rectifier K channel made of?
4 seperated subunit with 2 Transmembrane segment each
test 2 lec 3
what is the structural difference of the tandom channel eith other VDKC?
4 different sets of subunits with 4 transmembrane segments each, dimerize (2 sets of 4) to yield a single protein with 2 pores
test 2 lec 3
which potassium channel is considered both rectifying and VDKC?
Ik
test 2 lec 3
how does Ik activates?
activate when membrane is depolarized, and it is a HVA channel
test 2 lec 3
which one of the Rectifying channel is Slow inactivating?
all of them, Ik, HA and Anomalous, Ih, tandom pore
test 2 lec 3
which one of the Rectifying channel has no known blocker?
Tandom pore
test 2 lec 3
how does anomalous and IH channels are activated?
they are hyperpolarization activated
test 2 lec 3
what does anomalous and Ih channel do to the membrane potential?
they bring the membrane back to the resting potential by generating the inward K+ current
test 2 lec 3
how does the 2 activators of Tandom pore?
Halothane and Isoflurane, they recryfie the membrane potential, they bring it down to resting potential
,explain how local anesthetics work
test 2 lec 3
does changing the membrane voltage affect the activation of tandom pore?
no
test 2 lec 3
what is the effect of voltage change on tandom pore?
They are not affected by voltage
test 2 lec 3
what is the side effect of the chronic exposure to the Halothane?
they cause sever liver damage to the people who is in operating room that is exposed in daily bases
test 2 lec 3
what decreases the current flow in Metabotropic-gated channels ?
kinase’s activity (phosphorylation) decrease theoutward current to Metabotropic-gated channels
test 2 lec 3
what process can increase the current flow of Metabotropic-gated channels ?
phosphatases can increase the current flow to thoes channels.
test 2 lec 3
what are the four types of Metabotropic-gated channels?
Im,Iatp,Iahp,Isahp
test 2 lec 3
Metabotropic-gated channels are activated by:
they tight to ion channel which are activated indirectly by binding of ligand to receptor and binding of inactive G-protein to thoes receptor and then the exchange of GTP for GDP then the dissociation of alpha and beta-gamma subunit then _.. Read the process of G-protein life cycle
test 2 lec 3
what kinase is activated by CAMP?
PKA, it takes 4 CAMP to fully activates it, then that kinase can phosphorylate protein including these channels and inactivate them and decrease the flow of current.
