neuropharm flash card lec 5

Question 1

neuropharm lecture 5

regions of brain where NR1 can be found

Answer 1

everywhere there is an AMPA receptor

Question 2

neuropharm lecture 5

NR2a and NR2b can be found

Answer 2

in the forebrain and hippocampus

Question 3

neuropharm lecture 5

NR2c can be found

Answer 3

almost exclusively in cerebellum and olfactory bulb

Question 4

neuropharm lecture 5

NR2d can be found

Answer 4

cerebellum, midbrain, brainstem and olfactory bulb

Question 5

neuropharm lecture 5

unique structure of NRs

Answer 5

2NR1+2NR2 ( dual heterodimer= tetramer

Question 6

neuropharm lecture 5

NR2 bind

Answer 6

Glutamate

Question 7

neuropharm lecture 5

NR1 bind

Answer 7

Serine

Question 8

neuropharm lecture 5

Therapeutic uses of NMDARs

Answer 8

dissociative anesthesia, cough suppression, helping with learning and memory (ex: Alzhaimer), Ischemia neuroprotection, stroke and drowning

Question 9

neuropharm lecture 5

Non- therapeutic uses of NMDARs

Answer 9

Dissociative hallucinogen

Question 10

neuropharm lecture 5

NR1 antagonist that bind to PCP

Answer 10

PCP, angeldustin, MK801, Ketamine, memantine, dextromethorphan, nitrous oxide

Question 11

neuropharm lecture 5

effects of NR1 antagonist that bind to PCP

Answer 11

Dissociative anesthesia

Question 12

neuropharm lecture 5

Mg2+

Answer 12

NR1 antagonist that blocks open channels

Question 13

neuropharm lecture 5

PO4-

Answer 13

endogenous positive modulator(phosporylation) for NR1. it prolongs open channel

Question 14

neuropharm lecture 5

Ethanol

Answer 14

antagonist for NR1 that binds to ethanol and prevents channel openning

Question 15

neuropharm lecture 5

Ifenprodil

Answer 15

exogenous antagonist that bind to polyamine site of NR2 and decrease glutamate binding

Question 16

neuropharm lecture 5

two endogenous antagonist that bind to polyamine site of NR2

Answer 16

Cadaverine, putrescine

Question 17

neuropharm lecture 5

heavy metals

Answer 17

Decrease glutamate binding affinity

Question 18

neuropharm lecture 5

MK801

Answer 18

blocks excitotoxic apoptosis

Question 19

neuropharm lecture 5

competative agonist for NR2

Answer 19

NMDA, Glutamate(endogenous)

Question 20

neuropharm lecture 5

competative antagonist for NR2

Answer 20

APV (AP5), CPP

Question 21

neuropharm lecture 5

what can NR non-competitive antagonist cause in high doses?

Answer 21

impair learning

Question 22

neuropharm lecture 5

NR1 agonists

Answer 22

serine and glycine

Question 23

neuropharm lecture 5

NR1 partial agonist

Answer 23

DCS ( D- cycloserine)

Question 24

neuropharm lecture 5

NR1 competative antagonist

Answer 24

Kynurenate (Kyn)- endogenous, 5,7-Cl-Ky,

Question 25

neuropharm lecture 5

Glutamate EPSPs

Answer 25

heterogenous (mediated by multiple receptor type)

Question 26

neuropharm lecture 5

NMDA gene family

Answer 26

NR1, NR2a, NR2b, NR2c, NR2d, NR3a, NR3b

Question 27

neuropharm lecture 5

Gene families of AMPA

Answer 27

GLuR1, GLuR2, GLuR3

Question 28

neuropharm lecture 5

Hiil coefficient for glutmate binding of NR2

Answer 28

two

Question 29

neuropharm lecture 5

Hill coefficient for serine binding of NR1

Answer 29

two

Question 30

neuropharm lecture 5

Polyamine site

Answer 30

Where other types of receptors can bind

Question 31

neuropharm lecture 5

the only type of NT receptor system that requires 2 distinct sets of signals for activation

Answer 31

NMDA receptors

Question 32

neuropharm lecture 5

one of the most important functions of NMDA receptors

Answer 32

They are sites for Ca2+ influx