Test 2 Inflammation Flashcards
What help in the storage of fats? What helps in the release of fat as FFA’s?
Storage: Chylomicrons, VLDL (lipoprotein lipase)
Release:
ATGL, HSL (hormone sensitive lipase)
What neurotransmitters are signals in weight management?
NE
Dopamine
Serotonin
Orexin
What are the 8 category causes of obesity
- Genetics
- Sedentary lifestyle
- Inflammation (overeating and adipose produce inflammatory signals)
- Sleep patterns/stress (increased cortisol which increases appetite)
- taste, satiety and portions
- obesogens
- viruses
- gut micro flora
What are examples of obesogens that are one cause of obesity?
Endocrine disrupters
BPA, phthalates
What country spends the least amount of money on food? Most?
US
Most: azerbaijan
<16 BMI
Severe thinness
16-16.9
17-18.5
Moderate thinness
Mild thinness
Normal BMI
18.5-24.9
Pre-obese BMI
25-29.9
Obese class 1, 2, 3 BMI
1: 30-34.9
2: 35-39.9
3: 40+
Health waist circumference in males? Females?
Men: < 40
Female: < 35
Healthy waist to hip ratio men? Women?
Men: <0.95
Female: <0.8
Waist to height ratio male and female:
Underweight
Slim
Underweight Male and female: <0.35
Slim-male: 0.35-0.43
Female: 0.35-0.42
Waist to heigh ratio male/female-healthy?
Male: 0.43-0.53
Female: 0.42-0.49
Waist to height ratio male/female—obese?
Male: 0.58-0.63
Female: 0.54-0.58
Rate of weight loss for BMI 27-35?
0.5-1lb/wk for 6mo
Rate of weight loss for BMI >35?
1-2lbs/wk for 6 months
Lifestyle modifications for weight loss?
-Goal setting (Increase walking/1fruit at lunch) -Self-monitoring (diary/weigh ins) Stimulus control (ABC) Cognitive restructuring (challenge/correct negative thoughts)
Dietary modifications for weight loss
- restricted energy diets
- formula diets/meal replacements
- commercial programs
- very low calorie diets
- fasting
Restricted-energy diet
Calorie deficit of 500-1000
Focus on whole plants
Limit alcohol and high sugar
Formula diets/meal replacements
Lean cuisine, slim fast/cliff bars
Used to promote structure/portion sizes
Very low calorie diets
<800 cal/d
Only used on those with >30 BMI
Fasting
<200cal/d
50% of rapid weight loss is fluid
Increases likelihood of gout/gallstones
What diet is best for preservation of lean mass: alternate day fast or very low calorie?
Alternate day fasting
And on fasting days may eat up to 500 cal for female and males 600 cal
Recommended amount of physical activity for weight loss?
60-90 min/day
Weight maintenance: 150–250min/wk
What are some weight loss medications often prescribed?
Orlistat
Lorcaserin
Phentermine-topiramate
Orlistat
Pancreatic lipase inhibitor
GI upset, leaky stools
Ex: Xenical
Alli
Lorcaserin
Serotonin receptor agonist that acts as an appetite suppressant
HA, cough, fatigue, constipation (do not take with antidepressants)
Ex: Belviq
Phentermine-topiramate
Appetite suppressant
Tingling of hands and feet, dizziness, trouble sleeping and birth defects
Ex: Qsymia
Supplement for weight loss
CLA—required in 3.4g/day
Used to reduce body fat and build muscle
What supplements may act as fat burners?
Bitter orange
Green Tea Extract (heart arrythmias)
Raspberry ketones
What nutritional deficiencies are prominent in patients who have undergone bariatric surgery?
Iron
Ca
Vit D, B12
General causes of unintentional weight loss
Wasting-chronic infection Poor food intake Malabsorption Hormonal imbalances (thyroid) Increase in activity without increase in energy intake Poor living situation CA (cancer)
What are some major risk factors for CVD?
HTN Age Diabetes Microalbuminuria Family history
What are some modifiable risk factors for CVD?
Lipoproteins High LDL High TG High TMAO Low HDL Inflammatory markers (CRP, fibrinogen)
What are lifestyle risk factors for CVD
Smoking Poor physical activity Poor diet Stress Lack of sleep Alcohol
What are co-morbidities for CVD
HTN
Obesity
Metabolic syndrome
Desirable level for:
Total cholesterol
<200
Desirable level for:
HDL
> 60
Desirable level for:
LDL
<100
Desirable level for:
Triglycerides
<150
What is metabolic syndrome?
Having 3+ of the following:
Waist circumference > 40(M), >35 F TG: >150 HDL: <40 BP: >130/85 Fasting glucose: >110
What are some recommended swaps for decreasing risk of CVD?
- Swap trans fat for MUFA/PUFA
- Swap saturated fat for PUFA
- Do not swap UFA for carbs
Diets proved to decrease risk of CVD?
- Mediterranean
- DASH
- Vegan
What are the basics of the Mediterranean diet?
0-1 serving: eggs/dairy 0-2: vegetable oils 1-2: nuts/seeds 3-4: fruits 6-9: veggies 5-12: whole grains 1-3: legumes/soy
***mostly whole grains, veggies, and fruits
What are the basics of the DASH diet?
Low fat, low sodium diet
- plant based
- lean meats
- nuts
- seeds
- low-fat diary
- high potassium, mg, Ca, fiber
25-30% fat (MUFA) 25% protien
Limit foods that have more sodium than calories!!
Nutritional therapy for elevated LDL?
- Consume high veggies, fruits, whole grains. Some: low-fat dairy, poultry, fish, legumes/nuts
- Limit sweets, sugar sweetened beverages and red meat
- Aim for 7-10% of energy from saturated fat
- Avoid trans fat
- Exercise 3-4x/wk of mod/Vig.
Nutritional therapy for elevated TG
- Eat high veggie, fruit, whole grain. Some: low fat diary, poultry, fish, legumes, and nuts
- Limit sweets, sugar sweetened beverages and red meats
- 2-4g of EPA & DHA daily (omega 3)—FISH!!
- 3-4x/wk exercise
Normal BP
> 120
>80
Elevated BP
120-129 and >80
High BP stage 1
130-139 or 80-89
High BP stage 2
140+ or 90+
Hypertensive crisis
180+ and/or 120+
What 3 food/nutrients have the largest affect on BP?
Sodium (less than 2300mg)
Plant-based diet
Weight loss (3-5% body weight)
What is the nutritional therapy for hypertension?
- High veggies, fruits, whole grains. Some: low-fat dairy, poultry, fish, legumes, nuts
- Lower Na, increase K intake
- 3-4x/wk exercise
What are the 3 most preventable risk factors for chronic disease?
Unhealthy diet
Smoking
Physical inactivity
Deficiency
Low level of nutrient found in blood that CAUSES a specific disease
Insufficiency
Subclinical or deficiency nutrient pools due to chronic poor intake
Deficiency vs insufficiency-which MC to see in practice
Insufficiency
What are some chemical mediators in inflammation?
Cytokines
Lipid-derived compounds (prostaglandins, leukotrienes, thromboxanes)
ROS
Estimated that 30% of patients baseline level of inflammation is due to _______ produced by________q
Cytokines produced by adipocytes
More adipocytes= more inflammation
Gut inflammation precedes weight gain and adipocytes inflammation and can cause M2 macrophages to switch to M1 that have what effects?
M1: pro-inflammatory
Microbicidal
TH1 Rxn
Tissue damage
M1 means “kill”
Pathway of inflammation
- Diet/stress lead to changes in the gut microbiome. (More LPS-lipopolysaccharides produced with high fat diet.).
- Gut changes:
—> increased LPS activates NF-kB—> stimulate production of inflammatory cytokines—> produce ROS (also increase NF-kB) - Immune cell activation—aka systemic inflammation
What are some biomarkers of chronic inflammation
CRP
TNF-a
ESR
Liver: ALT/AST (liver inflammation), GGT (liver disease) Eosinophils (allergies, parasites, autoimmune, CA) Lipid peroxides (oxidative stress)
What are some nutrient modulators of inflammation
Omega 3/6 Mg Zn B complex vitamins Flavonoids
What are the co-enzymes and cofactors for AA and EPA?
Mg, Zn,
Vitamin A, C, B6, Niacin
Coenzyme: desaturase and elongase
What mineral acts as a calcium-channel blocker and low dietary intake is a major risk factor for chronic disease?
Magnesium
What are Mg’s balanace parterns?
Mg: Ca and Zn
What mineral is associated with obesity-induced inflammation?
Magnesium
RDA for Magneium (roughly)
310-320mg
What foods is Mg rich in?>
Nuts/seeds
What mineral deficiency causes decrease production of T-lymphocytes?
Zinc