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DMIC 5001 > Test 2: Antigens and Antibodies > Flashcards

Test 2: Antigens and Antibodies Flashcards

1
Q

Antigen traits

A
  • Immunogenicity
  • Antigenicity
  • Allergenicity
  • Tolerogenicity
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2
Q

Immunogen traits (antigens that cause an immune response)

A
  • molecular size
  • chemical composition and molecular complexity
  • Foreignness
  • Stimulate B/T cells
  • Degradability
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3
Q

Epitope

A

binding site of antigen, more complex forms attach better

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4
Q

Haptens

A

cannot stimulate antibody alone but can with a carrier

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5
Q

Autoantigen

A

antigen from within body

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6
Q

Alloantigen

A

antigen from same species

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7
Q

Heteroantigen

A

antigen from different species, can cause uncontrolled immune response

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8
Q

Heterophile antigens

A

antigen from two different species that have the same function

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9
Q

Adjuvant

A

substance with immunogen that increases immune response (included in vaccines)

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10
Q

MHC class I on APC

A

intracellular defense, cancer, viral (antigen already within cell)

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11
Q

MHC class II on APC

A

bacterial, anything extracellular, exogenous antigen

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12
Q

Isotype heavy chain

A

same heavy chain for each class of Abs

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13
Q

Allotype heavy chain

A

variations in constant regions of each class of Abs

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14
Q

Idiotype heavy chain

A

variations in variable regions that give specificity

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15
Q

IgG characteristics

A
  • monomer
  • 80% in serum
  • 1/2 life:23 days
  • initiates complement
  • ONLY ONE that crosses placenta
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16
Q

IgM characteristics

A
  • pentamer
  • 5-10% in serum
  • 1/2 life: 5 days
  • initiates complement
  • 1st antibodies during infection
17
Q

IgA characteristics

A

-dimer
-10-15% in serum
1/2 life: 6 days
-does not initiate complement

18
Q

IgD characteristics

A

-monomer
-.2% in serum
1/2 life: 3days
-present on naive B cells

19
Q

IgE characteristics

A
  • monomer
  • .002% in serum
  • 1/2 life: 2 days
  • bound to mast cells and basophils
  • doesn’t initiate complement
  • helps with allergies and parasites
20
Q

Cross reactivity

A

one antibody can bind with multiple antigens

21
Q

Streptococcus pyogenes

A

cell wall proteins called M antigens–can cross react with myocardial and skeletal muscle proteins

DMIC 5001 (15 decks)

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