Test 2 Flashcards
Population genetics
Study of the distribution of alleles in populations and causes of allele frequency changes
Allele frequency
- The proportion of all copies of a gene that is made up of a particular gene variant (allele)
- the number of copies of a particular allele divided by the number of copies of all alleles at the locus in a population
In population genetics, allele frequencies are used to depict..
The amount of genetic diversity at the individual, population, and species level
Who developed an equation for population genetics?
Hardy and Weinburg
Hardy-Weinburg equilibrium
Population allele frequencies do not change if:
- population is infinitely large
- geneotypes do not differ in fitness
- there is no mutation
- mating is random
- there is no migration
Through mathematical modeling based on probability, they concluded that..
Gene pool frequencies are inherently stable but that evolution should be expected in all populations virtually all of the time
Hardy-Weinburg theorem proves that allele frequencies do not change in the absence of..
Drift, selection, mutation, and migration
Mechanisms of ___ are forces that change allele frequencies
Evolution
___ frequencies predict ___ frequencies
Allele, genotype
Predictions from Hardy-Weinburg
p^2 + 2pq + q^2
p - frequency of dominant allele
q - frequency of recessive allele
1 in 1700 U.S. Caucasian newborns have ___
Cystic fibrosis
Genetic drift
- along with natural selection, mutation, and migration - is one of the basic mechanisms of evolution
- simply the evolutionary equivalent of a sampling error
Hardy-Weinburg serves as the fundamental ___ in population genetics
Null model
Drift reduces ___ in a population
Genetic variation
Alleles are lost at a faster rate in ___ populations
Small
Bottlenecks ___ genetic variation
Reduce
A bottleneck ___ genetic drift
Causes
Population bottlenecks occur when..
A populations size is reduced for at least one generation
Founder effect
Occurs when a new colony is started by a few members of the original population
Both drift and founder effect result from __
Random sampling
Fitness
Reproductive success of an individual with a particular phenotype
Components of fitness
- survival to reproductive age
- mating success
- fecundity
Relative fitness
Fitness of a genotype standardized by comparison to other genotypes
Natural selection is more powerful in ___ populations
Large
___ weaker in large populations
Drift
Alleles that lower fitness experience ___ selection
Negative
Alleles that increase fitness experience ___ selection
Positive
Additive
Allele yields twice the phenotypic effect when two copies present
Dominance
Dominant allele masks presence of recessive in heterozygote
Estimate of new mutations each generation in humans
9.8 billion
Frequency-dependent selection
An evolutionary process where the fitness of a phenotype is dependent on its frequency relative to other phenotypes in a given population
In positive (diversifying) frequency-dependent selection,
The fitness of a phenotype increases as it becomes more common
In negative (purifying) frequency-dependent selection,
The fitness of a phenotype increases as it becomes rarer
Inbreeding coefficient
Probability that two alleles are identical by descent
Polygenic trait
Influenced by many genetic loci
- interaction between alleles (epistasis)
- interaction with environment (phenotypic plasticity)
Quantitative genetics
Study of the genetic mechanisms of continuous phenotypic traits
Epistasis
Phenomenon in which the expression of one gene depends on the presence of one or more “modifier genes”
A gene whose phenotype is expressed is called ___.
Epistatic
A gene whose phenotype is altered or suppressed is called ___.
Hypostatic
Phenotypic plasticity
Ability of an organism to change its phenotype in response to changes in the environment
Phenomenon in Daphnia, known today as cyclomorphosis
When exposed to the presence of a predator they respond by altering the shape of their body to produce a “helmet”
Heritability
Proportion of phenotypic variance due to genetic differences
Broad sense of heritability includes:
- additive effects
- dominance effects
- epistatic effects
- maternal/paternal environmental effects
Natural selection
Only the organisms best adapted to their environment tend to survive and transmit their genetic characteristics in increasing numbers to succeeding generations while those less adapted tend to be eliminated
Natural selection will operate on anything that has the following properties:
- reproduction
- inheritance
- variation in fitness
- variation in individual characteristics
Directional selection
Favors those individuals who have extreme variations in traits within a population
- greyhound dog bred to run faster
Stabilizing selection
Favors the norm, the common, average traits in a population
- husky needs to be perfectly medium - too big will sink in snow, too small would not be strong enough