Test 2 Flashcards
what are the two important filarid nematodes
-dirofilaria immitis (dogs and cats)
-acanthocheilonema reconditum (dipetalonema, dogs)
why do we need to differentiate between the two filarid nematodes
one of them doesnt require treatment so you can get sued if you treat wrong
lifecycle of filarid nematodes (general)
female -> mocrofilariae (pre-L1) -> blood sucking insect -> L3 -> definitive host -> predilection site
general characteristics of acanthocheilonema reconditum (microfilariae, adults, intermediate host)
microfilariae
-no taper at anterior end
-shorter and narrower than dirofilaria immitis
adults
-slender, 5cm long
-within CT
-not pathogenic
intermediate host
-fleas (lice)
lifecycle of acanthocheilonema reconditum
flea feeds on dog and transmits infective larvae -> adult nematodes in SQ and perirenal tissues release microfilariae -> flea bites dog and ingests microfilariae with blood meal -> microfilariae develop in flea to infective larvar
dirofilaria immitis (definitive host, predilection site, intermediate host)
definitive host
-dogs, cats, ferrets, wild canids
predilection site
-right caudal lobar artery
intermediate host
-mosquitoes
adult and microfilariae morphology of dirofilaria immitis
adult
-female = 20-30cm long
-male = smaller, tail has loose spiral
-size and site = diagnostic
microfilariae
-tapered anterior end
-longer and wider than A reconditum
cycle of dirofilaria immitis
- a mosquito bites an infected animal, ingesting heartworm microfilariae (pre-L1)
- microfilariae mature into heartworm larvae (L3) inside mosquito (10-14)
- infected mosquito bites a dog, transmitting the larvae (L3)
- larvae enter the dogs bloodstream, migrate to the heart and lungs, grow to a foot long and become sexually mature (7-9 months)
- adult heartworms can live within the heart and lungs for 5-7 years
lifecycle of dirofilaria immitis
-larvae in pulmonary arterioles (d70)
-pre-patent period (~7-9m)
-parasites live 5-7 years (dogs)
maturation time of dirofilaria immitis in mosquitoes
18C = 29d
26C = 12d
30C = 8 days
what is the general timeframe for the ability to transmit L3 to dogs in southern ontario
starts = june 1
ends = oct 8
is there higher prevalence of heartworm disease north or south of the 400 series highways
south
dirofilaria immitis in cats
-prevalence < dogs
-often very few parasites
-adult parasites live 1-2 years
-microfilaremic ~1m
dirofilaria immitis pathogenesis (3)
-obstruction of blood flow
-parasite excretory products mechanical activity = proliferative pulmonary endarteritis
-dead/dying parasites —> pulmonary embolism
dirofilaria immitis large parasite burden pathogenesis
same changes -> pulmonary hypertension -> right ventricular hypertrophy -> heart failure