test 2 Flashcards
AFRS fungi (IGE sensitized)
Bipolaris, Curvularia, Exserohilum, Drechslera, Fusarium, Helminothosporium
- type 1 hypersensitivity to fungal antigens
- nasal polyps
- characteristic CT findings of high attenuation areas in affected sinuses
- eosinophilic mucin
- a positive fungal smear
AFRS criteria
increased nasal airflow
sympathetic activity, exercise, increased blood CO2, epinephrine
decreased nasal airflow
menstruation, puberty, pregnancy
positive methacholine challenge
20% fall in FEV1
T cells express to migrate to the skin
CLA, CCR4, CCR10, CRTH2
CCR7 expressed on T cells
migration of T cells into secondary lymphoid organisms through HEV
Heterozygous, germline, gain-of-function variants in CXCR4 (lymphocyte migration to secondary lymph nodes)
warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome
dermatitis, low platelets, recurrent infections
Wiskott Aldrich syndrome
chronic AD with impetigo, lung infections
Hyper IGe syndrome
infant with dermatitis, intractable diarrhea, diabetes, hypothyroid
IPEX
difficult to treat viral skin infections
Dock 8 deficiency
infant with dermatitis not responsive to steroids, periorificial rash, necrotic areas around the nose, diarrhea
zinc deficiency, acrodermatitis enteropathica
chemical preservative found in many water-based products such as sunscreen, cosmetics, hair products, liquid soap, laundry products, premoistened facial wipes and baby wipes.
methylisothiazolinone (MI)
sporting goods such as tennis rackets, building construction, and vehicle parts; therefore, favoring the distribution of the rash is on the hand
Bisphenol A
shoes and leather so the rash distribution is usually on the dorsum of the feet
potassium dichromate
dental implants, artificial joints, and engines
cobalt dichloride
contact derm hair products
- Cocamidopropyl betaine
- Para-phenylenediamine (PPD)
- Fragrances
- Preservatives
- Glycerol thioglycolate
fever, urticarial rash, conjunctival ingestion, arthralgia, attacks start hours after exposure to cold
FCAS (familial cold autoinflammatory syndrome)
IL-1 - anti is canakinumab
sudden onset of asthma, typically within minutes to hours after a single high-level exposure to an irritating agent, typically a gas, vapor, or smoke. no history of prior asthma
reactive airway dysfunction syndrome
evidence of exposure (history and positive IgG to culprit antigen), chest x-ray or high-resolution CT with reticular, nodular or ground-glass opacities, bronchoalveolar lavage with lymphocytosis > 20% but often >50% with CD4:CD8 ratio < 1, histopathology of lesion with non-caseating granulomas or mononuclear cell infiltrate and symptoms upon reexposure (positive inhalational challenge).
hypersensitivity pneumonitis
80-90% maximum heart rate for 8 minutes and 10% drop in FEV1
exercise challenge test
hazelnut protein birch pollen
cor a 1
components associated with clinical reactivity to hazelnut
cor a 8,9,14
