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board review Flashcards

1
Q

nonstandardized allergen extracts units

A

PNU/mL

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2
Q

tropomyosin cross reacting with shrimp`

A

der p 10

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3
Q

rat and mice allergens found in

A

urine

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4
Q

ozone

A

summer, highest in evening

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5
Q

immunotherapy changes

A

As the shift occurs from TH2 to TH1, IFN-γ goes up and IL-4 goes down, resulting in an increase in the ratio

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6
Q

FENO level caffeine

A

reduced

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7
Q

three major criteria of mAPI

A

asthma, personal atopic dermatitis and sensitization to aeroallergens; Elevated eosinophils and wheezing apart from colds are minor criteria in the mAPI

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8
Q

class swtiching

A

change in constant region

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9
Q

activation of AID, occurs in B cell follicle

A

somatic hypermutation

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10
Q

gM+, CD20+, CD27+, CD38+ and CD43+ cells

A

B1 B cells,seeded from the bone marrow during fetal development and self-renew from these peripheral cells for the rest of the individual’s life, do not require T cell help, bind antimicrobial carbohydrate antigens

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11
Q

UNG

A

hyper IgM with no recurrent infections

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12
Q

SH3 binds

A

proline residues

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13
Q

Most TLR activation results in .

A

NFkB activation

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14
Q

All TLRs utilize IRAK4/MyD88 to signal except

A

TLR3

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15
Q

TCR diversity

A

N additions placed by TdT ; shuffling of different V segments, D segments and J segments.

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16
Q

TLR activation results in processing of pro-IL-1beta to

A

IL-1beta

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17
Q

US most common cause introperative anaphylaxis

A

antibiotics

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18
Q

seen in patients receiving exogenous sources of glucocorticosteroids

A

Homogenous and posterior cataracts

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19
Q

atopic keratoconjunctivitis

A

anterior cataract development

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20
Q

Factor H deficiency is associated with

A

Neisserial infections and hemolytic uremic syndrome

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21
Q

atrial myxoma secretes

A

IL-6

22
Q

Allergens that can present with positive results beyond 5 days

A

metals (gold, potassium dichromate, nickel and cobalt), antibiotics (neomycin, bacitracin), corticosteroids, dyes (p-pheneylenediamine, disperse blue) and acrylates.

23
Q

marker of activation in BAT

A

CD69

24
Q

dendritic cell complement receptor

A

CR4

25
Q

B lymphocyte coreceptor complex

A

CD19 21 (CR2) 81

26
Q

CD11c/CD18

A

integrin beta chain (LAD-1)

27
Q

ICs cause disease with

A

moderate antigen excess

28
Q

Type IVB

A

DRESS, morbilliform drug rash

29
Q

NLRP3 inflammasome

A

caspase cleaves pro-IL1beta to IL-1beta

30
Q

Myd88/IRAK4

A

TLR signaling pathway except TLR3

31
Q

TLR 3 signaling

A

TRIF and TRAF

32
Q

mature naive T cells express

A

CCR7 and migrate along CCL19/21 gradient into LN parafollicular zone

33
Q

T cells express to get out of LN

A

S1P1

34
Q

Th1 tx factor

A

Tbet, STAT4

35
Q

Th2 tx factor

A

STAT6, GATA3

36
Q

Th17 tx factor

A

RORgammaT, STAT3

37
Q

T reg tx factor

A

Foxp3, STAT5

38
Q

central memory T cells

A

CD45RA neg, CD27 pos, CCR7 pos, CD62 pos (L-selectin), home to LNs

39
Q

effector memory T cells

A

CD45RAneg, CD27 neg, CCR7 neg, CD62 neg (L-selectin), home to peripheral sites

40
Q

B cells express CXCL5 migrate into

A

LN via CXCL13

41
Q

follicular B cells activated by

A

CCR7

42
Q

memory B cells express high levels of

A

anti-apoptotic Bcl-2

43
Q

plasma cells home to BM maintained by

A

BAFF

44
Q

class switching need

A

CD40/40L, AID, UNG - if absent, hyper IgM syndrome

45
Q

somatic hypermutation occurs in

A

germinal center

46
Q

intrinsic lymphocyte apoptosis

A

Bim binds Bax and Bak -> cytochrome c, caspase 9

47
Q

extrinsic lymphocyte apoptosis

A

FasL to Fas -> caspase 8

48
Q

ILC2 express

A

GATA3

49
Q

mast cell and basophil tx factor

A

GATA2

50
Q

eosinophil tx factor

A

GATA1

51
Q
A

board review book (5 decks)

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