Test 2 Flashcards
How do drugs work
Mimic neurochemistry
Antagonist
Blocks neurotransmitter
Agonist
Increases neurotransmitter
How are drugs categorized
Predominant effect
What do stimulants do
Increased excitement, alertness, motor activity, and elevate mood
Ex of stimulant drugs
Amphetamines, cocaine, Ritalin, ecstasy, nicotine
Cocaine and amphetamines do what in the brain
Block dopamine transporters/reuptake
Ritalin blocks DA transporters/reuptake at a more _____ rate
Gradual
Why do hyperactive kids respond well to stimulants
It’s a way for their body to regulate activity
Needs more dopamine
What is nicotine’s receptor?
ACH
What does nicotine do in the brain
Causes nucleus accumbens to release more dopamine than normal
Opiate drugs:
Decrease sensitivity to pain/increase relaxation
Where do fentanyl and heroin work in the brain
Natural endorphin system
What are endorphins?
Androgynous peptides; indirect agonist of DA
What do endorphins do?
Inhibit GABA, flood of dopamine
What does GABA do?
Break down DA
What do hallucinogenic drugs do in the brain?
Distort perceptions by binding to and stimulating 5HT receptors for too long
Autoreceptors
Presynaptic receptors sensitive to the same neurotransmitter they release
What kind of reinforcement do autoreceptors provide? How?
Negative. Detect the amount of transmitter released and inhibit further synthesis and release
Synapse
Specialized gap between neurons
Placed rats in a Skinner Box that allowed self-stimulation of brain by pressing lever -
rats pressed over 2,000 time per hour to release DA in nucleus accumbens
What behaviors release DA
Sexual excitement
Gambling
Video games
Major depression ___________ response in the nucleus accumbens
Less than normal
Small parts of the nucleus accumbens respond to ______
Pleasure (liking)
______ parts of the nucleus accumbens respond to motivation/wanting
Larger
Affinity
How well drug binds to receptor
If a drug binds fast and strong it has a ____ affinity
High
Efficacy
Relationship between receptor occupancy and the ability to initiate a response
Affected by how well the drug can bind to a receptor, affinity, and how it is able to cause a reaction
Potency
Methylphenidate blocks
The reuptake of DA more gradually
Tetrahydocannabinol (THC)
Main active ingredient in marijuana
Endogenous cannabinols
Anandamide and 2-AG
Types of Hallucinogens
LSD MDMA (ecstasy)
What is long-term use of hallucinogenic drugs associated with
Impaired memory and learning and loss of 5HT (DA) receptors
MDMA is a _____ in small doses and a _____ in larger doses
Stimulant, hallucinogen
Alcoholism that has
Later onset
Gradual onset
Fewer genetic relatives with alcoholism
Type 1/Type A alcoholism
Type 2/Type B alcoholism
Earlier onset
More rapid onset
More genetic relatives
What does research on sons of alcoholic fathers conclude>
Less average intoxication after 1 drink
Stress decreased more than for the avg person after a drink
Smaller than normal amygdala
Do genes influence the likelihood alcoholism
Yes
How does Antabuse work?
Antagonizing the effects of acetaldehyde dehydrogenase (it makes u throw up)
Methadone
Opiate Used to combat substance abuse, similar to heroin and morphine, satisfies cravings
Dorsal
Towards the back
Ventral
Toward stomach
Towards the front
Anterior
Posterior
Toward rear
Inferior
Below
Superior
Above
Lateral
Toward side, away from midline
Toward midline, away from side
Proximal
Close to point of attachment
Distal
Far from point of origin/attachment
Ipsilateral
Same side
Contra lateral
Different side
Coronal plane
Shows sutures from front