Test #1

Question 1

myeloid vs lymphoid

Answer 1

lymphoid = T and B cells
myeloid = everything else

Question 2

mechanism of Tpo

Answer 2

produced in liver at constant rate, binds to receptor MPL and promotes platelet production

Question 3

MPL

Answer 3

receptor for Tpo, leads to production of platelets

Question 4

bone marrow aspiration occurs…

Answer 4

anywhere in children, axial skeleton in adults

Question 5

acute vs chronic hematologic malignancies

Answer 5

acute = blast
chronic = mature

Question 6

CD20

Answer 6

B cell marker

Question 7

Ages of ALL and AML

Answer 7

AML - older

ALL - younger

Question 8

genetic disorders that cause leukemia

Answer 8

down syndrome, kleinfelter, Turner, neurofirbomtosis, fanconi anemia

Question 9

clinical presentation of leukemia

Answer 9

leukostasis, BM faliure, coagulopathy, extra medullary manifestations, metabolic abnormalities

Question 10

leukostatis more common in….

Answer 10

AML

Question 11

coagulopathy in leukemia

Answer 11

elevated PT and PTT, low fibrinogen

Question 12

extramedullary manifestations in ALL

Answer 12

lymphadenopathy, mediastinal mass, CNS rare, testes

Question 13

tumor lysis syndrome

Answer 13

in ALL - massive cell turnover can lead to renal faliure

Question 14

hypokalemia in AML

Answer 14

tubular damage by lysozyme release in myeloblasts

Question 15

hypoglycemia in leukemia

Answer 15

artifical after blood draw

Question 16

Auer rods

Answer 16

linear aggregates of granules in myeloblasts

Question 17

M3 classification of AML

Answer 17

promyelocytic, hypergranular,

Question 18

diagnosis of AML vs ALL

Answer 18

AML - lysozyme, myeloperoxidase, esterase in monocytic subtype

ALL - TdT is enzyme in lymphblast

Question 19

treatment/support in leukemia

Answer 19

• transfusion if platelets below 10,000
• leukostatis - fluids, hydroxyurea, steroids (ALL)
• DIC - replace with FFP and replacement of firbinogen
• tumor lysis - hydration, allopurinol to block uric acid, rasburicase for uric acid

Question 20

APL - acute promeylotic leukemia

Answer 20

15:17 translocation of retinoic acid

Question 21

15:17

Answer 21

APL - type of AML (M3), Auer rods, favorable, treatment with retinoic acid

Question 22

8:21

Answer 22

favorable AML - core Biding factor CBF alteration

Question 23

unfavorable AML

Answer 23

del5Q del7q, 11q23(MLL), inv3

Question 24

myeloblast markers

Answer 24

CD13, CD33, CD117

Question 25

12:21

Answer 25

favorable ALL, TEL-AML1 genes in children

Question 26

9:22

Answer 26

unfavorable in ALL, brc-abl fusion protain

Question 27

MLL 11q23

Answer 27

unfavorable ALL, commin in children

Question 28

lymphoma staging

Answer 28

1- single node group
2- two groups on same side of diaphragm
3- two groups on different sides of diaphragm
4- extranodal disease

Question 29

staging symptoms of NHL

Answer 29

• fevers without source
• night sweats
• > 10% weight loss

Question 30

prognosis factors of NHL

Answer 30

APLES

• Age
• Performance(naps)
• LDH
• Extranodal
• Stage

Question 31

8:14

Answer 31

c-Myc:IGH - burkitt’s lymphoma

Question 32

most lymphoma are _ cell origins

Answer 32

B

Question 33

A vs B in lymphoma

Answer 33

A - local

B- systemic

Question 34

most common indolent NHL

Answer 34

follicular

Question 35

most common aggressive NHL

Answer 35

diffuse large B cell