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Heme/onc > Drug names > Flashcards

Drug names Flashcards

1
Q

cyclophosphamide

A

nitrogen mustard

  • acrolein
  • hemorrhagic cyctitis
  • cardiotoxic
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2
Q

ifosfamide

A

nitrogen mustard

  • P450 for activation
  • more acrolein
  • penetrates BBB**
  • blue**
  • neurotoxic
  • nephrotoxic
  • hemorrhagic cyctitis
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3
Q

chlorambucil

A

nitrogen mustard

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4
Q

melphalan

A

nitrogen mustard

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5
Q

cisplatin

A

platinum analog

  • nausea, vomiting
  • nephrotoxic
  • neurotoxic
  • ototoxic
  • visual disturances
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6
Q

carboplatin

A

platinum analog

  • hypersensitivity
  • neurotoxic in past cisplatin users
  • taxane first
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7
Q

oxaliplatin

A

platinum analog

  • sensory neuropathy in COLD
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8
Q

dacarbazine

A

triazene

part of ABVD for hodgkins

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9
Q

doxorubicin

A

anthracyclines - topo II inhibitor

  • *cardiotoxic (radicals) - CHF - monitor EF
  • meylosuppression
  • vessicant
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10
Q

daunorubicin

A

anthracyclines - topo II inhibitor

  • *cardiotoxic (radicals) - CHF - monitor EF
  • meylosuppression
  • vessicant
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11
Q

methotrexate

A

antimetabolic

  • *fluid space
  • leucovorin resuce
  • nephrotoxic
  • Gi toxic
  • hepatotoxic
  • derm problems
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12
Q

5-flurouracil

A

antimetabolic

  • inhibits thymidylate synthase
  • mucositis
  • diarrhea
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13
Q

hydroxyurea

A

antiometabolic/analog

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14
Q

cytarabine

A

pyrimidine analog

  • pyrimidine analog
  • cross BBB
  • mucositis
  • ***cerebellar toxic
  • ocular toxic
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15
Q

gemcitabine

A

pyrimidine analog

  • deoxycytidine analog
  • myelosuppression
  • flu like
  • radiosensitizer
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16
Q

fludarabine

A

purine analog

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17
Q

bleomycin

A

anti-tumor antibiotic

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18
Q

vincristine

A

vinca alkaloid

  • microtubule formation
  • peripheral neuropathy
  • constipation**
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19
Q

vinblastine

A

vinca alkaloid

  • microtubule formation
  • myelosuppression
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20
Q

vinorelbine

A

vinca alkaloid

  • microtubule formation
  • myelosuppression and peripheral nueropathy
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21
Q

paclitaxel

A

taxane

  • meylosuppresion
  • peripheral neuropathy
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22
Q

docetaxel

A

taxane

  • meylosuppresion
  • peripheral neuropathy
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23
Q

irinotecan

A

camptothecin

  • topoisomerase I inhibitor
  • meylosuppresion
  • diarrhea (GI)
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24
Q

dexamethasone

A

glucocorticoid

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25
Q

prednisone

A

glucocorticoid

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26
Q

danazol

A

androgen

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27
Q

flutamide

A

anti-androgen

  • hot flash
  • libido
  • LFT
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28
Q

bicalutamide

A

anti-androgen

  • hot flash
  • libido
  • LFT
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29
Q

tamoxifen

A

anti-estrogen

  • menopause
  • DVT
  • edema
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30
Q

raloxifene

A

anti-estrogen

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31
Q

anastrozole

A

aromatase inhibitor

  • athenia
  • hot flash
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32
Q

letrozole

A

aromatase inhibitor

  • arthralgia
  • hot flash
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33
Q

exemestane

A

aromatase inhibitor

  • hot flash
  • fatigue
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34
Q

leuprolide

A

LH-RH agonist

  • hot flash
  • cholesterol
  • edema
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35
Q

goserelin

A

LH-RH agonist

  • hot flash
  • cholesterol
  • edema
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36
Q

trastuzumab

A

anti-HER2

  • infusion
  • pain
  • myelosuppresion
  • cardio
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37
Q

bevacizumab

A

anti-VEGF

    • wound healing/hemorrhage
  • anything with blood
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38
Q

cetuximab

A

anti-EGFR

  • infusion
  • rash
  • hepatotoxic
  • NV
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39
Q

rituximab

A

anti CD-20

  • NHL
  • immunosuppressive (hep B)
  • tumor lysis
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40
Q

eculizumab

A

anti-complement (C5)

41
Q

brentuximab

A

anti-CD30

42
Q

ipilimumab

A

anit-CTLA4

43
Q

nivolumab

A

anti-PD1

44
Q

imatinib

A

BCR-ACL inhibitor

  • fluid retention
  • myelosuppression
45
Q

thalidomide

A

imid

  • antiangiogenesis (antiVEGF)
  • immunomodulatory (apoptosis)
  • sensory
  • sedation
  • cardiovascular
46
Q

lenalidomide

A

imid

  • antiangiogenesis (antiVEGF)
  • immunomodulatory (apoptosis)
  • sensory
  • sedation
  • cardiovascular
  • antiangiogenesis (antiVEGF)
  • immunomodulatory (apoptosis)
47
Q

azacytidine

A

demethylating agent

  • MDS
  • myelosuppression
  • NV
48
Q

decitabine

A

demethylating agent

  • MDS
  • myelosuppression
  • NV
49
Q

bortezomib

A

proteasome inhibitor

  • fatigue
  • malasie
  • myelosuppression
50
Q

ATRA

A

vitamin A analog

51
Q

ATO

A

arsenical

52
Q

enoxaparin

A

LMWH

53
Q

dalteparin

A

LMWH

54
Q

fondaparinux

A

synthetic heparin

55
Q

lepirudin

A

direct thrombin inhibitor

56
Q

argatroban

A

direct thrombin inhibitor

57
Q

dabigatran

A

direct thrombin inhibitor

58
Q

idarucizumab

A

reversal agent of dabigatran

59
Q

rivaroxaban

A

Direct factor Xa inhibitor

60
Q

abciximab

A

GpIIb/IIIa antagonist

61
Q

aminocaproic acid

A

anti-fibrinolytic

62
Q

romiplostim

A

thrombopoietin mimetic

63
Q

eltrombopag

A

thrombopoietin mimetic

64
Q

ondansetron

A

serotonin antagonist

  • headache
  • QT
65
Q

aprepitant

A

NK-1 antagonist

  • for delayed vomiting
  • hiccup
66
Q

dexamethasone

A

glucocorticoid

-glucose intolerace

67
Q

prochlorperazine

A

dopaminergic antagonist

  • for delayed vomiting
  • extrapyramidal
68
Q

metoclopramide

A

dopaminergic antagonist

  • for delayed vomiting
  • extrapyramidal
69
Q

leucovorin

A

stabilizes 5-FU

rescues from methotrexate

70
Q

mensa

A

binds acrolein in bladder, protects from ifosfamide

71
Q

atropine

A

treatment for early onset diarrhea

72
Q

atropine

A

treatment for early onset diarrhea in irinotecan

73
Q

filgrastim

A

G-CSF

  • fever, bone pain
74
Q

pegfilgrastim

A

G-CSF

  • fever, bone pain
75
Q

RhoGAM, WinRHo

A

anti-D immune globulin

76
Q

bleomycin

A

antibiotic

  • treat hodgkin disease
  • lung toxicity
77
Q

Li-Fraumeni

A

sarcoma, breast, leukemia

78
Q

PTEN

A

Cowden, hamartomas, papilloma, breast, thyroid

79
Q

CDHI (gastric cancer syndrome)

A

gastric, breast

80
Q

APC

A

colon

81
Q

LKB1

A

colon

82
Q

MMR

A

colon - lynch syndrome

83
Q

CDKN2

A

melanona

84
Q

p16lnk4a

A

melanoma

85
Q

MTS1

A

melanoma

86
Q

base exicision repair

A

xerderma pigmentosum

87
Q

VHL

A

pheochromocytoma

88
Q

NF1

A

neurofibromatosis

89
Q

CA-125

A

ovarian

90
Q

CK

A

carcinoma

91
Q

EMA

A

carcinoma

92
Q

LCA

A

lymphoma

93
Q

S100

A

melanoma

94
Q

chromogranin

A

neuroendocrine

95
Q

synaptophysin

A

neuroendocrin

96
Q

NSE

A

neuroendocrin

97
Q

AFP

A

germ cell

98
Q

vimentin

A

sarcoma

Heme/onc (5 decks)

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