Drug names Flashcards
1
Q
cyclophosphamide
A
nitrogen mustard
- acrolein
- hemorrhagic cyctitis
- cardiotoxic
2
Q
ifosfamide
A
nitrogen mustard
- P450 for activation
- more acrolein
- penetrates BBB**
- blue**
- neurotoxic
- nephrotoxic
- hemorrhagic cyctitis
3
Q
chlorambucil
A
nitrogen mustard
4
Q
melphalan
A
nitrogen mustard
5
Q
cisplatin
A
platinum analog
- nausea, vomiting
- nephrotoxic
- neurotoxic
- ototoxic
- visual disturances
6
Q
carboplatin
A
platinum analog
- hypersensitivity
- neurotoxic in past cisplatin users
- taxane first
7
Q
oxaliplatin
A
platinum analog
- sensory neuropathy in COLD
8
Q
dacarbazine
A
triazene
part of ABVD for hodgkins
9
Q
doxorubicin
A
anthracyclines - topo II inhibitor
- *cardiotoxic (radicals) - CHF - monitor EF
- meylosuppression
- vessicant
10
Q
daunorubicin
A
anthracyclines - topo II inhibitor
- *cardiotoxic (radicals) - CHF - monitor EF
- meylosuppression
- vessicant
11
Q
methotrexate
A
antimetabolic
- *fluid space
- leucovorin resuce
- nephrotoxic
- Gi toxic
- hepatotoxic
- derm problems
12
Q
5-flurouracil
A
antimetabolic
- inhibits thymidylate synthase
- mucositis
- diarrhea
13
Q
hydroxyurea
A
antiometabolic/analog
14
Q
cytarabine
A
pyrimidine analog
- pyrimidine analog
- cross BBB
- mucositis
- ***cerebellar toxic
- ocular toxic
15
Q
gemcitabine
A
pyrimidine analog
- deoxycytidine analog
- myelosuppression
- flu like
- radiosensitizer
16
Q
fludarabine
A
purine analog
17
Q
bleomycin
A
anti-tumor antibiotic
18
Q
vincristine
A
vinca alkaloid
- microtubule formation
- peripheral neuropathy
- constipation**
19
Q
vinblastine
A
vinca alkaloid
- microtubule formation
- myelosuppression
20
Q
vinorelbine
A
vinca alkaloid
- microtubule formation
- myelosuppression and peripheral nueropathy
21
Q
paclitaxel
A
taxane
- meylosuppresion
- peripheral neuropathy
22
Q
docetaxel
A
taxane
- meylosuppresion
- peripheral neuropathy
23
Q
irinotecan
A
camptothecin
- topoisomerase I inhibitor
- meylosuppresion
- diarrhea (GI)
24
Q
dexamethasone
A
glucocorticoid
25
prednisone
glucocorticoid
26
danazol
androgen
27
flutamide
anti-androgen
- hot flash
- libido
- LFT
28
bicalutamide
anti-androgen
- hot flash
- libido
- LFT
29
tamoxifen
anti-estrogen
- menopause
- DVT
- edema
30
raloxifene
anti-estrogen
31
anastrozole
aromatase inhibitor
- athenia
- hot flash
32
letrozole
aromatase inhibitor
- arthralgia
- hot flash
33
exemestane
aromatase inhibitor
- hot flash
- fatigue
34
leuprolide
LH-RH agonist
- hot flash
- cholesterol
- edema
35
goserelin
LH-RH agonist
- hot flash
- cholesterol
- edema
36
trastuzumab
anti-HER2
- infusion
- pain
- myelosuppresion
- cardio
37
bevacizumab
anti-VEGF
- * wound healing/hemorrhage
- anything with blood
38
cetuximab
anti-EGFR
- infusion
- rash
- hepatotoxic
- NV
39
rituximab
anti CD-20
- NHL
- immunosuppressive (hep B)
- tumor lysis
40
eculizumab
anti-complement (C5)
41
brentuximab
anti-CD30
42
ipilimumab
anit-CTLA4
43
nivolumab
anti-PD1
44
imatinib
BCR-ACL inhibitor
- fluid retention
- myelosuppression
45
thalidomide
imid
- antiangiogenesis (antiVEGF)
- immunomodulatory (apoptosis)
- sensory
- sedation
- cardiovascular
46
lenalidomide
imid
- antiangiogenesis (antiVEGF)
- immunomodulatory (apoptosis)
- sensory
- sedation
- cardiovascular
- antiangiogenesis (antiVEGF)
- immunomodulatory (apoptosis)
47
azacytidine
demethylating agent
- MDS
- myelosuppression
- NV
48
decitabine
demethylating agent
- MDS
- myelosuppression
- NV
49
bortezomib
proteasome inhibitor
- fatigue
- malasie
- myelosuppression
50
ATRA
vitamin A analog
51
ATO
arsenical
52
enoxaparin
LMWH
53
dalteparin
LMWH
54
fondaparinux
synthetic heparin
55
lepirudin
direct thrombin inhibitor
56
argatroban
direct thrombin inhibitor
57
dabigatran
direct thrombin inhibitor
58
idarucizumab
reversal agent of dabigatran
59
rivaroxaban
Direct factor Xa inhibitor
60
abciximab
GpIIb/IIIa antagonist
61
aminocaproic acid
anti-fibrinolytic
62
romiplostim
thrombopoietin mimetic
63
eltrombopag
thrombopoietin mimetic
64
ondansetron
serotonin antagonist
- headache
- QT
65
aprepitant
NK-1 antagonist
- for delayed vomiting
- hiccup
66
dexamethasone
glucocorticoid
-glucose intolerace
67
prochlorperazine
dopaminergic antagonist
- for delayed vomiting
- extrapyramidal
68
metoclopramide
dopaminergic antagonist
- for delayed vomiting
- extrapyramidal
69
leucovorin
stabilizes 5-FU
| rescues from methotrexate
70
mensa
binds acrolein in bladder, protects from ifosfamide
71
atropine
treatment for early onset diarrhea
72
atropine
treatment for early onset diarrhea in irinotecan
73
filgrastim
G-CSF
- fever, bone pain
74
pegfilgrastim
G-CSF
- fever, bone pain
75
RhoGAM, WinRHo
anti-D immune globulin
76
bleomycin
antibiotic
- treat hodgkin disease
- lung toxicity
77
Li-Fraumeni
sarcoma, breast, leukemia
78
PTEN
Cowden, hamartomas, papilloma, breast, thyroid
79
CDHI (gastric cancer syndrome)
gastric, breast
80
APC
colon
81
LKB1
colon
82
MMR
colon - lynch syndrome
83
CDKN2
melanona
84
p16lnk4a
melanoma
85
MTS1
melanoma
86
base exicision repair
xerderma pigmentosum
87
VHL
pheochromocytoma
88
NF1
neurofibromatosis
89
CA-125
ovarian
90
CK
carcinoma
91
EMA
carcinoma
92
LCA
lymphoma
93
S100
melanoma
94
chromogranin
neuroendocrine
95
synaptophysin
neuroendocrin
96
NSE
neuroendocrin
97
AFP
germ cell
98
vimentin
sarcoma
