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Heme/onc > quiz > Flashcards

quiz Flashcards

1
Q

Fanconi

A

DNA repair and damage, 12 different genes

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2
Q

Shwachman Diamond

A

same gene, ribosomal RNA, mitotic spindle

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3
Q

dyskeratosis

A

telomerase function abnormally short, Xlinked

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4
Q

congenital amegakaryocytic thrombocytopenia

A

thrombocytopenia and absent kegakaryocytes, mutations in MPL

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5
Q

paroxysmal nocturnal hemoglobinuria

A

hemolysis and BM failure, less GPI anchor on RBC, complement lysis, thrombosis

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6
Q

toxic granulation

A

dark granules in neutrophils seen with infection or G-CSF

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7
Q

Dohle bodies

A

ribosome rich ER seen in sepsis, G-CSF use

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8
Q

Pelger-Huet

A

bilobed nucleus, myelodysplastic syndrome

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9
Q

anemia

A

decrease in hemoglobin and hemotocrit

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10
Q

MCV

A

size of RBC

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11
Q

MCH

A

hemoglobin concentration

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12
Q

MCHC

A

hemoglobin concentration in volume of red cells

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13
Q

RDW

A

red cell distribution

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14
Q

reticulocyte

A

pre red cell

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15
Q

retic count

A

percentage of retics in RBC

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16
Q

reticulocyte index

A

retic count X Hct / 40

should be greater than 2 in anemic patient with good response

17
Q

hypo vs hyper proliferative depends on…

A

reticulocyte index or absolute retic count

18
Q

tranferrin

A

iron transport in blood

19
Q

hepcidin

A

prevents iron release, prevents absorption, prevents iron export

20
Q

serum ferritin

A

relfect iron stores

21
Q

labs in iron def

A

low MCV
low MCH
decreased RBC
low retic

22
Q

serum iron studies in Fe def

A

low serum Fe
High TIBC - transferrin can bind
Ferritin - low
transferritin sat - low

23
Q

difference in anemia of chronic disease in iron test

A

decreased TIBC and increased or normal ferritin

24
Q

hereditary spherocytosis

A

defects in spectrin, ankyrin, band 3 and pallidin, memebrane deformability

25
Q

labs in HS

A

reticulocytes, spherocytes, osmotic fragility test, increase MCHC

26
Q

things seen in G6PD

A

Heinz bodies, ghost cells and bite cells

27
Q

warm vs cold AIHA

A

warm - IgG

cold IgM

Heme/onc (5 decks)

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