Test #1 Flashcards
hallmark of anxiety
avoidance
blackbox warning for SSRIs
suicidal ideation
the great masquarader
trauma and PTSD
qualification of ADHD
must experience symptoms in 2 settings
MOA of methylphenidate
promotes the release of dopamine and norepinephrine into the synapse
main side effects of stimulants (methylphenidate)
insomnia, psychosis in high doses, CV issues, high blood pressure to to increase in NO, GI issues
Methylphenidate avoid in…
patients taking MAO inhibitors (will lead to too much norepi in system)
Atomoxetine
used for ADHD treatment, selectively inhibits norepi reuptake, can not be abused, CYP metabolism is important
Guanfacine
alpha-2 agonist - antihypertensive, non-stimulant, also used for ADHD treatment
Caffeine
Competitive inhibitor of adenosine receptors, keep you awake
modafinil MOA
increases dopamine levels via inhibition of reuptake
use of modafinil
excessive sleepiness caused by narcolepsy
Gamma hydroxybutryate
actually a CNS depressant, exhibit effects on GABA and dopamine, used for treatment of cataplexy in nacoleptic patients
sibutramine and phentermine
anorexiants, promotes norepi release,
topiramate
used with phentermine for weight loss, mechanism unlcear
Lorcaserin
selective serotonin agonist for weight loss
mesolimibic
antipsychotic positive symptoms
mesocortical
antipsychotic negative symptoms
nigralstriatal
extrappyrimidal movements
tuberoinfundibular
prolactin release
MOA of most antipsychotics
blockade of dopamine receptors
major side effect of typical antipsychotic drugs
extrapyramidal symptoms due to blockade of dopamine receptors - leads to movement disorders
side effects of atypical antipsychotic drugs
insulin resistance, dyslipidemia and weight gain due to antagonism of histamine and serotonin receptors
difference in use in older and newer agents
older helps with positive symptoms, Newer helps with Negative symptoms
