Test #1

Question 1

hallmark of anxiety

Answer 1

avoidance

Question 2

blackbox warning for SSRIs

Answer 2

suicidal ideation

Question 3

the great masquarader

Answer 3

trauma and PTSD

Question 4

qualification of ADHD

Answer 4

must experience symptoms in 2 settings

Question 5

MOA of methylphenidate

Answer 5

promotes the release of dopamine and norepinephrine into the synapse

Question 6

main side effects of stimulants (methylphenidate)

Answer 6

insomnia, psychosis in high doses, CV issues, high blood pressure to to increase in NO, GI issues

Question 7

Methylphenidate avoid in…

Answer 7

patients taking MAO inhibitors (will lead to too much norepi in system)

Question 8

Atomoxetine

Answer 8

used for ADHD treatment, selectively inhibits norepi reuptake, can not be abused, CYP metabolism is important

Question 9

Guanfacine

Answer 9

alpha-2 agonist - antihypertensive, non-stimulant, also used for ADHD treatment

Question 10

Caffeine

Answer 10

Competitive inhibitor of adenosine receptors, keep you awake

Question 11

modafinil MOA

Answer 11

increases dopamine levels via inhibition of reuptake

Question 12

use of modafinil

Answer 12

excessive sleepiness caused by narcolepsy

Question 13

Gamma hydroxybutryate

Answer 13

actually a CNS depressant, exhibit effects on GABA and dopamine, used for treatment of cataplexy in nacoleptic patients

Question 14

sibutramine and phentermine

Answer 14

anorexiants, promotes norepi release,

Question 15

topiramate

Answer 15

used with phentermine for weight loss, mechanism unlcear

Question 16

Lorcaserin

Answer 16

selective serotonin agonist for weight loss

Question 17

mesolimibic

Answer 17

antipsychotic positive symptoms

Question 18

mesocortical

Answer 18

antipsychotic negative symptoms

Question 19

nigralstriatal

Answer 19

extrappyrimidal movements

Question 20

tuberoinfundibular

Answer 20

prolactin release

Question 21

MOA of most antipsychotics

Answer 21

blockade of dopamine receptors

Question 22

major side effect of typical antipsychotic drugs

Answer 22

extrapyramidal symptoms due to blockade of dopamine receptors - leads to movement disorders

Question 23

side effects of atypical antipsychotic drugs

Answer 23

insulin resistance, dyslipidemia and weight gain due to antagonism of histamine and serotonin receptors

Question 24

difference in use in older and newer agents

Answer 24

older helps with positive symptoms, Newer helps with Negative symptoms