drugs

Question 1

amphetamine

Answer 1

for ADHD treatment, releases more monoamine transmitters, can cause CV problems and psychosis, dependence

Question 2

methylphenidate

Answer 2

for ADHD treatment, releases more monoamine transmitters, can cause CV problems and psychosis, dependence

Question 3

atomoxetine

Answer 3

For ADHD treatment, selective reuptake inhibitor, selective for norepinephrine, CYP is important for metabolism, mild antimuscarinic properties, increase suicidal ideation

Question 4

guanfacine

Answer 4

For ADHD treatment, MOA unclear, centrally acting alpha-2 agonist, causes sedation and hypotension

Question 5

caffeine

Answer 5

For sleep, adenosine receptor antagonist, increased arousal, cardiac and smooth muscle effects, anorexia

Question 6

modafinil

Answer 6

Stimulant, blocks dopamine transporter, increases synaptic dopamine and increases sensitivity of dopamine receptor

Question 7

gamma hydroxybutyrate

Answer 7

Used for cataplexy and refractory narcolepsy, give a strong sleep and wakefullness the next day, GABA and dopamine like effects

Question 8

phentermine

Answer 8

Anorexiant, NE transporter inhibition, promotes NE release

Question 9

topiramate

Answer 9

Used in combination with phentermine for weight loss

Question 10

lorcaserin

Answer 10

anorexiant, 5HT receptor agonist

Question 11

bupropion + naltrexone

Answer 11

Anorexiant, DA reuptake inhibitor and opioid receptor antagonist

Question 12

chlorpromazine

Answer 12

older agent, antipsychotic, low potency

Question 13

perphenazine

Answer 13

older agent, antipsychotic, medium potency

Question 14

haloperidol

Answer 14

older agent, antipsychotic, high potency

Question 15

Clozapine

Answer 15

newer agent, antipsychotic, SA - weight gain, metabolic problems, seizures, agranulocytosis

Question 16

Risperidone

Answer 16

newer agent, antipsychotic

Question 17

Olanzapine

Answer 17

newer agent, antipsychotic

Question 18

Quetiapine

Answer 18

newer agent, antipsychotic

Question 19

Aripiprazole

Answer 19

newer agent, antipsychotic

Question 20

diphenhydramine and benztropine

Answer 20

used for treating acute dystonic reactions in patients with psychosis taking anti-psychotics, anticholinergic - balances low dopamine with lower Ach

Question 21

levodopa

Answer 21

used for parkinson treatment, crosses the BBB, converted to dopamine

Question 22

carbidopa

Answer 22

used for Parkinsons treatment, inhibits peripheral carboxylase to allow levodopa in the brain

Question 23

entacapone

Answer 23

COMT inhibitor, prevents breakdown of Levadopa in periphery, used as adjunctive therapy, can cause nausea, diarrhea and colored urine

Question 24

selegiline and rasagiline

Answer 24

MAO type B inhibitors, results in accumulation of dopamine, causes nausea and dizziness

Question 25

Pramipexole

Answer 25

Non-ergot dopamine agonist, less dyskinesia, harder to dose, caution with driving, compulsive behavior

Question 26

Ropinirole

Answer 26

Non-ergot dopamine agonist, less dyskinesia, harder to dose, caution with driving, compulsive behavior

Question 27

Apomorphine

Answer 27

Used for intermittent treatment of hypomobility, orthostatsis