Test 1 Flashcards
Where does SJW grow naturally?
USA and Europe
What is the scientific name of St. John’s Wort?
Hypericum perforatum
What part or SJW plant is used?
Aerial portion - harvested during the flowering season
What are the two important active constituents of SJW?
Hypericin
Hyperporfin
Describe the bioavailability and metabolism of SJW
Both are poorly understood
What are 5 physiological effects of SJW?
- Inhibits monoamine oxidase
- Inhibition of neurotransmitter reuptake
- Modify receptors and modulate the hypothalamic-pituitary-adrenal axis
- Induces cytochrome P-450 activity
- Effects metabolism of several drugs
What has clinical research shown SJW to be effective for?
Mild to moderate depression by reducing sadness, hopelessness, worthlessness, exhaustion and poor sleep
(Ancient Greece - neuralgia, anxiety, neurosis, depression)
The Detoxification/Restorative Program assumes that exposure to xenobiotics may occur from
which parts of the external environment?
Fat stored drugs and chemical residue coming from medical and pharmaceutical drugs as well as industrial, commercial and agricultural chemicals.
How are exercise and heat used in detoxification strategies?
The program is designed to increase mobilization of toxic substances, sauna to make them sweat and prevent their re-absorption and recirculation.
Name the five organs of detoxification.
Intestine, liver, kidney, skin, lungs.
What are the sources of endotoxin production in the human body?
Free radicals and their metabolites from ionizing radiation, low polyunsaturated fat, and inadequate antioxidant nutrients and cofactors.
What is the relationship between intestinal dysbiosis and systemic diseases?
Bad type of bacteria in the gut will create a bad environment including toxins. Our cells need perfect nutrition for optimal health. Abnormal flora de-activates some digestive enzymes. The GI tract is the largest immune organs in the body
What is the relationship between food allergy and intestinal hyperpermeability?
Allergies can be an irritant that leads to hyperpermeability.
What happens in Phase 1 of Liver detoxification?
Cytochrome P-450 mixed function oxidase enzyme pathway. Enzymes in cells of liver membrane and are synthesized when exposed to certain chemicals and converts toxins into less harmful chemicals and produce free radicals. The free radicals can be converted into potentially carcinogenic items.
What happens in Phase 2 of liver detoxification?
Conjugation pathway. The liver adds another substance to a toxic chemical. This makes the toxin water soluble, and can then be excreted in bile or urine. This conjugation is done with sulphur-containing amino acids
Name the four methods for restoring detoxification function of the intestine.
Improve digestion, improve elimination, treat hyperpermeability, improve intestinal microecology (dysbiosis).
Describe the detoxification methods used in the Hubbard program
Daily doses of Niacin to stimulate lipid mobilization, moderate aerobic exercise, intermittent sauna to force sweating, ingestion of cold-pressed oils to help prevent re-absorption, Vitamin and mineral supplements.
. As reported in the scientific literature, what types of health problems and toxic exposures has
the Hubbard program been successfully used to treat?
Reducing levels of foreign compounds stored in fat, and significantly improve neurological function.
How could a patient have an allergy that is provoking symptoms without knowing they have an allergy?
Symptoms of food allergy or intolerance may not be triggered immediately after reintroduction of the foods; therefore, a person can get an erroneous impression their allergy or intolerance is cured. With repeated ingestion of the food, however, symptoms may gradually return
What are the pros and cons of laboratory testing for food allergies?
Costly and often unreliable, because there are several possible mechanisms for allergic responses, and lab tests must usually be specific for one mechanism, such as either IgE or IgG. Furthermore, some known mechanisms are not testable at this time, such as T-cell mediated sensitivities.
What foods are almost always eliminated in a food allergy elimination diet?
Wheat, corn, citrus, soy, other legumes, nuts, milk, eggs, beef, pork, shellfish, coffee, tea, chocolate, yeast
Describe how you would explain the method of the allergy elimination and challenge program to a patient
Food allergies and intolerance are best treated by avoidance of the offending food for a prescribed period of time, followed by a “rotation” diet, in which problem foods are only eaten every three to four days, instead of daily
What health problems or risks may be helped by the prostaglandin-modification program?
Chronic inflammation, conditions relating to platelet function, smooth muscle irritability, cardiovascular disease, reducing Triglycerides.
What food sources of arachidonic acid should be limited in the prostaglandin-modification program?
Animal flesh, dairy fats, egg yolk.
What foods can be eaten frequently to improve the balance between “friendly” and “unfriendly” prostaglandins?
Cofactors for optimal prostaglandin metabolism like vitamin B6, magnesium, zinc. Provide precursors or friendly prostaglandins.
What are the sources for gamma-linolenic acid supplementation?
2-6 capsules of borage oil, 6-18 capsules of primrose oil
What are the sources like For omega-3 fatty acid supplementation?
2-4 oz, fish has 1000mg, need 5-10 high-potency fish oul capsules per day.
What precautions should be taken when using Omega 3’s?
Omega-3 can lead to increased bleeding time and should be avoided by people that bleed easy. During pregnancy strictly avoid fish oil that has high levels of retinol (vitamin A). Avoid supplements that contain mercury.
What are three mechanisms behind the concept of an anti-inflammatory diet?
Eicosanoid modification, allergy elimination, natural substances (often found in plants) can lower indicators of systemic inflammation
What foods would typically appear in the anti-inflammatory diet (AI)?
- fruits, vegetables, good sources of Omega-3 FA, whole grains, brown rice, lean protein like chicken, ginger, curry, and other spices.
What foods should be limited or removed in the AI diet?
saturated or trans fats, refined carbs, white rice, red meat, dairy, refined or processed foods.
What are the 5 steps in the dyslipidemia care pathway? (very long answer, sorry)
1- Determine serum lipids, preferably full lipoprotein analysis after 12 hour fast.
2- Evaluate history of the primary risk factors. Men over 45 women over 55 (or postmenopausal), Family history of premature CHD (MI or sudden death) before 55 years in first degree relative male or 65 in first degree female, cigarette smoking, hypertension 140/90 and above or taking antihypertensive meds, HDL below 40, High HDL above 60 will take one risk factor away.
3- Determine the 10-year risk assessment for patients with 2 or more primary risk factors.
4- Determine required interventions for LDL cholesterol from the table.
5- Determine whether additional interventions are required for the metabolic (insulin-resistance) syndrome when any three of the following are present: abdominal obesity, TG levels 150 or above, Blood pressure is 130/85, fasting glucose 100 or above.
What clinical measurements are needed to assess whether the metabolic syndrome is present?
abdominal obesity, TG levels 150 or above, Blood pressure is 130/85, fasting glucose 100 or above.
. Which three dietary fats are limited in the Therapeutic Lifestyle Changes?
Saturated, trans, cholesterol
What additional dietary interventions beyond the Therapeutic Lifestyle Changes can also
specifically affect LDL levels?
Increase fiber from fruit, vegetables, whole grains, oat bran, flaxseed, glucomannan.
How may alcohol intake either improve or worsen certain serum lipid levels?
1-2 drinks a day for men or 1 for women can increase HDL levels.
Which supplements can have the most dramatic effects on LDL levels?
Red yeast rice, niacin, phytosterols, pantethine.
Which supplements can have the most dramatic effects on HDL levels?
Niacin, policosanol, chromium, gugulipid, pantetine, phytosterols.
Which supplements can have the most dramatic effects on triglyceride levels?
Fish oil, niacin, pantethine, inostitol hexaniacinate.
When might it be advisable to refer the patient to a dietitian or a personal trainer?
those marked for elevated LDL if elevations are severe or unresponsive to conservative interventions within 3-6 months. Choose those marked for elevated triglycerides if unresponsive to conservative interventions within 3-6 months
Explain why some supplements are reserved for aggressive intervention only
Can cause problems with liver and are basically the same as statins (red yeast rice).
How does excessive alcohol affect hypertension and the various types of dyslipidemia?
It can add 2-3 systolic points if more than 1-2 drinks a day.
What nutrients do the DASH diet supply that might contribute to its blood-pressure lowering
effect?
Vegetables, fruits and low fat dairy products. Also has very low Levels of sodium.
Which dietary supplements show the most promise for effectively lowering blood pressure?
Coenzyme Q and Garlic
What common foods are high in salt?
• Fast foods, pizza • Ethnic foods (Asian, Mexican, etc) • Salty snack foods (chips, crackers, pretzels, nuts, etc) • Smoked, cured, preserved, pickled foods (sausage, ham, lunchmeats, hot dogs, olives, pickles, etc.) • Tomato products • Cheese products • Canned soups • Canned vegetables
What precautions must be followed when recommending increased potassium intake?
Need to make sure the kidneys can eliminate the potassium. Can be contraindicated with kidney disease, some elderly patients, diabetic patients, and patients taking potassium-sparing diuretics.
Which supplements should be used for those with insulin resistance?
chromium, coenzymeQ, and magnesium.
What levels should you lower in order to reduce risk of stroke? and how would you do this?
Homocysteine reduction can lower the risk of strokes. Lower homocysteine levels by B12, B6, Whole grains, legumes, fruits, vegetables.
how can you reduce oxidized LDL levels?
stop smoking, increase monosaturated fats, vitamin E and C, Plant polyphenols.
. Which diets or supplements have been shown to prevent, slow, or reverse atherosclerosis in
humans?
Omega-3 polyunsaturated fatty acids, vitamin E, alcohol.
What foods have been combined into the cardiovascular risk reduction diets known as the Dietary Portfolio and the Polymeal?
Diets low in saturated fats, and use soy protein, nuts.
. Name the two or three best interventions for modifying insulin resistance
weight loss, low glycemic diet, chromium, magnesium, Co Q10
. Name the two or three best interventions for modifying coagulation dysfunction
asprin, Vitamin E, Alcohol, garlic
. Name the two or three best interventions for modifying vascular inflammation
Quit smoking, antioxidants, plant based diet, prostaglandin-modification.
. Name the two or three best interventions for modifying elevated homocysteine
folic acid, B12, B6, Plant based diet.
. Name the two or three best interventions for modifying oxidized LDL
quit smoking, meditranean diet, Vit E C, polyphenols.
. Name the two or three best interventions for modifying endothelial dysfunction/vascular compliance
Quit smoking, antioxidants, healthy diet, aerobics, polyphenols, fix everything else listed above.