TEST 1 Flashcards
Fertilization
Fusing of ovum and sperm
*Starting point of pregnancy //typically occurs around 2 weeks after last normal menstrual period in 28-day cycle
How many sperm are contained in ejaculated semen?
200 mil/ML
Zona Pellucida
Clear protein layer blocks sperm
Disappears in about 5 days
Sex determination is determined when and how
at fertilization and on whether the ovum is fertilized by Y bearing sperm or X bearing sperm.
XX zygote becomes?
XY zygote becomes?
XX - Female
XY - Male
Ectoderm forms?
Central nervous system, special senses, skin and glands
Mesoderm forms
Skeletal, urinary, circulatory, and reproductive organs
The endoderm forms?
Respiratory system, liver, pancreas and digestive system
Where does fertilization take place?
In ampulla of fallopian tube
Union of sperm and ovum forms?
zygote (46 chromosomes)
Cleavage cell division continues to form a
Morula (mass of 16 cells)
The inner cell mass is called?
Which forms?
Blastocyst
Forms embryo and amnion
The outer cell mass is called?
which forms?
Trophoblast
Placenta and chorion
Implantation occurs –how many days>? and where
7-10 days after conception in endometrium
When do the embryonic membranes begin to form?
around time of implantation
What does the chorion consist of?
Trophoblast cells and mesodermal lining
Chorionic villi?
Finger like projections from chorion
What does the amnion originate from?
What is amnion?
Expands until?
-Ectoderm germ layer
-It is a thin protective membrane that contains amniotic fluid.
-It expands until it touches the chorion (outer layer)
*These two layers form fluid filled amniotic sac
How much amniotic fluid is there at term?
approx 1 L
Where is amniotic fluid derived from?
Fluid transported from maternal blood across the amnion and fetal urine
What does amniotic fluid do?
-Help maintain consistent body temp
-Permit symmetric growth and development, -Cushion the fetus from trauma
-Allow umbilical cord to be free from compression
-Promote fetal movement to enhance musculoskeletal development.
Amniotic fluid is composed of ?
Alkaline or acidic?
Contains?
98% water, 2% organic matter
-Slightly alkaline
-Contains albumin, urea, bile, renin, glucose, hormones, uric acid, creatinine, bilirubin, lecithin, sphingomyelin, epithelial cells, vernix and fine hair.
Oligohydramnios
Too little amniotic fluid <500 mL at term
What is oligohydramnios associated with
uteroplacental insufficiency, fetal renal abnormalities, and higher risk of surgical births and low birth weight
Hydramnios
too much amniotic fluid
(>2000mL at term)
What is hydramnios associated with
maternal diabetes, neural tube defects, chromosomal deviations and malformations of CNS and/or GI tract that prevent normal swallowing of amniotic fluid by fetus
**threaten premature rupture of membranes due to uterine over distention
Umbilical cord is formed from
amnion
Umbilical cord contains how many veins and arteries?
1 large vein
2 small arteries
Wharton jelly?
Specialized connective tissue
SUrrounds 3 blood vessels in umbilical cord to prevent compression
Umbilical cord reaches max length at?
Avg cord is how long
30 weeks
22 inches long, 1 inch wide
What are the precurser cells of placenta?
Trophoblasts
What makes hCG and what does it do?
as early as 3 days after conception, the trophoblasts make hCG
hCG hormone ensures the endometrium will be receptive to implanting the embryo.
What does the placenta do?
Makes hormones to control basic physiology of the mother so fetus is supplied with nutrients and oxygen
Protects fetus from immune attack
Removes waste products
Induces mother to bring more food
HOrmones to ready fetal organs for life
Placenta function depends on
Maternal blood pressure supplying circulation
Placental barrier
Fetal tissues that separate maternal blood and fetal blood
Materials are only interchanged through diffusion
What delivers nutrients to the placenta?
What carries fetal waste away?
Maternal uterine arteries
Mothers uterine veins carry fetal waste away
What week is the structure of the placenta completed?
usually week 12
Chorionic gonadotropin (CG)
Preserves the corpus luteum and its progesterone production so that the endometrial lining is maintained.
*The basis for pregnancy test
Prolactin
Mediates maternal metabolic adaptations to pregnancy by regulating insulin production and sensitivity; plays an important role in lactation
Human placental lactogen (hPL)
modulates fetal and maternal metabolism, participates in the development of maternal breasts for lactation, and decreases maternal insulin sensitivity to increase its availability for fetal nutrition
Estrogen (Estriol)
Causes enlargement of a womans breasts, uterus, and external genitalia, stimulates myometrial contractility
Progesterone (progestin)
Maintains the endometrium, decreases the contractility of the uterus, stimulates maternal metabolism and breast development, provides nourishment for early conceptus
Relaxin
Potent vasodilator and regulates maternal hemodynamics. Acts synergistically with progesterone of the pelvic ligaments, soften cervix in prep for birth
Teratogens
Substances that cause birth defects
(alcohol, drugs, infections, radiation, nutritional deficiencies
Fetal stage
from 8th week until birth
Longest period of prenatal development
Conceptus is mature enough to be called fetus
The lung function is taken over by what during fetal life? and where does fetal circulation oxygenation occur?
Placenta & placenta
What 3 shunts are present during fetal life?
Ductus venosus
Ductus arteriosus
Foramen ovale
Ductus venosus
Bypasses liver and connects the umbilical vein to inferior vena cava
Ductus arteriosus
bypasses the lungs and connects the main pulmonary artery to descending aorta
Foramen ovale
bypasses the right ventricle and lungs via an anatomic opening between the right and left atrium
What carries oxygenated blood from placenta to fetus?
What carries unoxygenated blood from?
umbilical vein
2 umbilical arteries
Genetics
Genomics
Genetics - study of heredity and its variation
Genomics - study of all genes and includes interactions among genes and its environment
Amniocentesis and chorionic villus sampling test what
confirm genetic anomaly
a fetal nuchal translucency test can suggest
presence of trisomy 21 or down syndrome if nuchal thickness is found
Genome
entire hereditary information encoded on DNA
Each chromosome is made up of_____
and define
Genes - individual units of heredity of all traits and are organized into long segments of DNA that occupy a specific location on a chromosome to determine a particular characteristic in an organism
Genotype
Genotype - specific genetic makeup of an individual, usually in form of DNA
Allele
1 of 2 or more alternative versions of a gene at a given position or locus on chromosome
Phenotype
the observed or outward characteristics of an individual
Homozygous
Heterozygous
Homozygous - same for charaterisitc
Heterozygous - different
Humans have how many chromosomes?
How many nonsex or autosomes and how many sex?
46
22 pairs of non sex
1 pair of sex
Karyotype
pictorial analysis of the number, form and size of an individuals chromosomes
Ex 46, XX for a female
46 XY for a male
Mendelian laws of inheritance
Patterns occur because a single gene is defective and disorders that result are referred to as monogenic or mendelian
Monogenic disorders include:
Autosomal dominant
Autosomal recessive
X-linked dominant
X-linked recessive
Autosomal dominant inheritance disorder
occur when a single gene in the heterozygous state is capable of producing the phenotype
**mutant gene overshadows normal gene and person will show signs
Common types of genetic disorders that follow autosomal dominant pattern of inheritance include
neurofibromatosis, marfan syndrome, hungtington disease, achondroplasis, polycystic kidney disease
Autosomal recessive inheritance disorders
occur when 2 copies of the mutant gene in homozygous state are necessary to produce the phenotype
Common types of genetic disorders that follow autosomal recessive inheritance include
Cystic fibrosis
phenylketonuria
Tay-sachs disease
Sickle cell disease
X-linked inheritance disorders
associated with altered genes present on X chromosome
Male - will express conditon bc they have only one X
Females - have 2 X so either heterozygous or homo
X linked recessive inheritance
demonstrated recessive pattern of inheritance
More affected males than females bc all genes on male are X so it will be expressed
Females will need 2 abnormal X to exhibit otherwise are carriers
No male to male transmission // male will have carrier daughters
Common types of genetic disorders that follow X linked recessive include
Hemophilia
Color blindness
Duchenne muscular dystrophy
X-linked dominant inheritance
Conditions
When a male has abnormal X chromosome or female has 1 abnormal X
**have lethal results in males
Rare
Hypophophatemic rickets and fragile X syndrome
Multifactorial inheritance disorders
thought to be caused by multiple gene and environment factors
Nontraditional inheritance patterns and examples
Do not follow typical patterns
Mitochondrial inheritance and genomic imprinting
Mitochondrial inheritance
Examples
Usually passed from mother to offspring
Often seen in one or more organs - brain, eye and skeletal muscle
Often assoc with energy deficits in cells with high energy requirements such as nerve and muscle cells
Ex. Kearns-Sayre syndrome and lebers hereditary optic neuropathy
Genomic imprinting
Phenomenon by which the expression of a gene is determined by its parental origin //both maternal and paternal alleles are present but only 1 is expressed
Ex Prader-willi syndrome, angelman syndrome, beckwith-wiedemann syndrome
Chromosomal abnormalities
Do not follow striaghtforward pattern of inheritance
Occur due to random events during formation of reproductive cells
-most occur due to error in egg or sperm