Ch 19, 20, 21 Flashcards
Biophysical risk factors for women
Genetic conditions
Chromosomal abnormalities
Multiple pregnancies
ABO incompatibility
Large fetus
Medical and oB conditions
Preterm
Cardiovascular disease (HTN)
Cervical insufficiency
Placental abnormalities
INfection, diabetes
Maternal collagen disease
Thyroid, asthma
Post term preg
Hemoglobinopathies
Nutritional status
Underweight/overweight
Hematocrit less than 33%
Psychosocial risk factors affecting womens pregnancy
Smoking
Caffeine
Alcohol and substance abuse
Maternal obesity
Inadequate support system
Situational crisis
History of violence
Emotional distress
Unsafe cultural practices
Sociodemographic risk factors affecting womens pregnancy
Poverty
Lack of prenatal care
Younger than 15, older than 35
Parity - all 1st and more than 5
Matiral statis - increased risk for unmarried
Ethnicity - increased risk for non-white women
Environmental risk factors affecting womens pregnancy
Infections
Radiation
Pesticides
Illicit drugs
industrial pollutants
Second hand cig smoke
Personal stress
Abortion
Loss of early pregnancy, usually before week 20
Can be spontaneous or induced
Spontaneous abortion
Loss of fetus resulting from natural causes
Stillbirth
Loss of fetus after 20th week
Miscarriage
Loss before week 20
What are the maternal conditions that can contribute to spontaneous abortions in 2nd trimester?
Cervical insufficiency, congenital or aquired anomaly of uterine cavity, hypothyroidism, DM, Chronic nephritis, cocaine, thrombophilias, lupus, PCOS, HTN, acute infection - rubella, cytomegalovirus, herpes, BV and toxoplasmosis.
Ectopic preg occur 1 in every ____
50
2% of preg in US
What medications are used for ectopic pregnancy?
Methotrexate
Prostaglandins
Misoprostol
Actinomycin
What is methotrexate typically used for
Chemotherapeutic treatment of leukemia, lymphomas, and carcinomas
Linear salpingostomy
used to preserve the tube - important for women who want to keep their fertility for future
The complete mole is assoc with development of
Choriocarcinoma
Partial mole has __karyotype?
triploid 69 chromosomes bc two sperm cells provided a double contribution by fertilization ovum
How does a complete mole present
uterine enlargement greater than expected, hyperemesis and pre-eclampic symptoms
What happens in molar pregnancy?
Trophoblastic cells that normally would form placenta proliferate and chorionic villi become edematous. They become grapelike clusters
What are 5 remarkable features of molar pregnancy?
Ability to invade into the wall of uterus
Recur in subseq pregnancies
Poss develop into choriocarcinoma
Influence of nutritional factors, protein def
Affect older women more
Symptoms of choriocarcinoma
SOB - indicative of metastasis to the lungs (most common site)
*asian, native and African increased risk
What is the patho for cervical insufficiency
Increased relaxin, when pressure of expanding uterus becomes greater than ability of cervical sphincter, cervix relaxes, allowing effacement and dilation
What is possibly the reason for cervical insufficiency
Congenital cervical hypoplasia, inutero DES exposure, trauma to cervix, amputation, OB lacteration, forced cervical dilation, prolonged 2nd stage of labor, increased relaxin and profesterone, increased uterine volume
Cervical cerclage
Sewing closed the cervix
Cervical pessary
a round silicone device at mouth of cervix
Complications assoc with cervical cerclage
suture displacement
rupture of membranes,
chorioamnionitis
How is cervical shortening viewed on ultrasound
as funneling. Amount can be determined by dividing funnel length by cervical length
Placenta accreta
placenta directly attached to myometrium
Placenta increta
Placenta penetrated into myometrium
Placenta percreta
Placenta invade myometrium into peritoneal covering, causing rupture of uterus
What are the risks for placental abruption
Ob hemorrhage, need for blood transfusions, em hysterectomy, DIC, sheehan syndrome, pp gland necrosis, renal failure
If a women develops DIC treatment focuses on
underlying cause
replacement therapy by transfusion of fresh frozen plasma factors along with cryoprecipitate
What is DIC
bleeding disorder characterized by an abnormal reduction in elements involved in blood clotting resulting from widespread intravascular clotting
DIC can occur secondary to
placental abruption, amniotic fluid embolism, endotoxin sepsis after abortion, retained fetus, posthemorrhagic shock, hydatidiform mole, HELLP syndrome, gyn malignancies
Complications of DIC
acute kidney failure
hepatic dysfunction
cardiac tamponade
gangrene
loss of digits
shock
death
What labs assist in diagnosis of DIC
Decreased fibrinogen and platelets
prolonged PT and aPTT
Positive D-dimer test and fibrin degradation products
Signs and symptoms of DIC
Bleeding gums
tachycardia
oozing from IV insertion site
petechiae
When is placenta accreta typically diagnosed
after birth
What are the theories for hyperemesis gravidarum
Endocrine
Metabolic
Genetic
Psycholigical
Endocrine - high level of hCG and estrogen
Metabolic - vit b def
Genetic - may predispose
Psycholigical - stress increase symptoms
What is the first choice for fluid replacement for hyperemesis gravidum
Normal saline which aids in preventing hyponatremia, which vitamins b6 and electrolytes added
What are nonpharmacological methods to treat myeremesis gravidum
Acupressure, hypnosis, massage, therapeutic touch, ginger, wear se-bands,
What happens if hyperemesis gravidum goes untreated?
can lead to neurological disturbances, renal damage, dehyrdation, ketosis, hypokalemia, retinal hemorrhage and/or death
What do the following lab tests tell about hyperemesis gravidum
Liver enzymes
CBC
Urine keytones
Liver enzymes - rule out hepatitis, pancreatitis, cholestasis; elevation of aspartate aminotrasnferase (AST) and (ALT) are usually present
CBC - elevated rbc and hematocrit - dehydration
**Urine keytones **- postive when body breasks down fat with inadequate intake
What do the following lab tests tell about hyperemesis gravidum
TSH and T4
Blood urea nitrogen
Urine specific gravity
serum electrolytes
Ultrasound
**TSH and T4 **- rule out thyroid disease
**Blood urea nitrogen **- increased in presence of salt and water depletion
Urine specific gravity - greater than 1.025 - linked to inadequate fluid intake or excessice loss, ketouria
serum electrolytes - decreased levels of potassium, sodium, and chloride, hydrochloric acid
Ultrasound - eval for molar preg or muliple gestation
Chronic HTN
exists prior to preg or develops before 20wks with bp greater than 140/90
Gestational htn
New onset bp elevation (140/90) id after 20 wks without proteinuria; bp returns to normal by 12 weeks pp
PreE/E and HELLP
develops with proteinuria after 20wks
Multisystem of:
elevated creatinine, liver involvement, epigastric or ab pain, neurological complications, hematologic and ueteroplacental dysfunction
Chronic htn w. superimposed pE
Develops afte 20wks
increased maternal / fetal morbidity rates
Risk factors for development of preE
Multifetal gestation, prev preg with preE, renal disease, autoimmune disease, DM, 1st preg, periodontal disease, chronic HTN, obesity
Define proteinuria
300mg or more of urinary protein per 24hrs more than 1+ protein by chemical reagent strip or dipstick of at least 2 random urine samples collected at least 4-6 hours apart
What to monitor when giving mag sulf
Serum mag levels
Assess DTRs, check for ankel clonus
Monitor for signs of toxicity, flushing, sweating, hypotension, cardiac and CNS dep