terms Flashcards
Oligodendrocytes assist the myelin sheath where?
Central Nervous System
Schwan cells assist the myelin sheath where?
Nerves outside the brain and spinal cord
What function do microglia serve? What do they play a role in?
Immune function, play a role in learning and memory.
What is the degeneration of Microglia linked ith?
Alzheimer’s
What are asrocytes use for?
Formation of the immune system for the brain
What disease are astocytes linked to?
Neurodegenerative diseases
What % water is a neuron made of?
80%
What are the dissolved chemicals in a neuron?
Na+, Cl-, K+
Acetylcholine
Excitatory
Learning, muscle action
Glutamate
Excitatory
Learning, movement
GABA
Inhibitory
Learning, anxiety regulation through inhibition of neurons
Dopamine
Both
Learning, reward/pleasure
Serotonin
Both
Elevation/depression of mood
Norepinephrine
Both
Elevation/depression of mood
Endorphins/Enkaphlains
Both
Regulation of pain responses
CT scan
Computerized Tomography
Uses x-rays that pas through body, can generate images of “slices” of the body
ex. detect changes in structure to to disease
pros/cons of CT scan
pro:
- Fast, cheap, non-invasive
con:
- radiation exposure
- only less us see the structures of the brain, not the brain in action
MRI
Magnetic Resonance Imaging
Uses magnetic fields to image alignments of H+ ions (diff tissues have diff amts of water
ex. can detect changes in structure due to disease
pros/cons of MRI
pro:
- noninvasive, great precision, no radiation
con:
- very expensive
- cannot have biomedical devices or metal in patients
- just gives an image of the brain, not the brain in action
fMRI
functional MRI
uses magnetic fields to image alignments of H+ ions. exposed to magnetic field –> tracks oxygenated blood
More active parts of brain will consume more oxygenated blood
ex. can measure activation during task/stimulation
DTI
Diffusion Tensor Imaging
tracks and images water movement alone neural pathways, can measure density of neural tracts (bundles of axons). Tracks nerves of the brain and the connections between different areas
ex. study white matter degeneration in disease
pros/cons of DTI
pro:
- noninvasive
- no radiation
- no injections
con:
- interpretation can be difficult in tracts with diff kinds of fibers
pros/cons of fMRI
pro:
- noninvasive
- no radiation
- no injections
con:
- cardiovascular disease/compromise function can make measurements unreliable –> elay between stimulus/output
- shows the brain in action
PET/SPECT
Single Photon Emission Computed Tomography
Uses ingested radioactive compound to track molecular changes, person is injected with radioactive substance
ex. visualize the activity of specific neurotransmitters
What substance are patients usually injected with for a PET scan?
Glucose
Pros/cons of PET/SPECT
pro:
- can see molecular changes in real time
- determine which part of brain is more active
- can see brain in action
con:
- radiation exposure
What is psychology
SCIENTIFIC study of how we think, feel, and behave
Why can we not rely on common sense?
common sense for one person may not be common sense for another
it does not generate new knowledge
Rationalism
We must use pure logic reasoning, and critical thinking
–> senses are deceiving and we cannot use them to learn about the natural work
Empiricism
We must use our senses, experiences, and systematic observations
What did Kant say?
We must use both are sense and our logic so that we can put things together in a coherent and meaningful way
what is the scientific method
- identify
- gather info
- develop hypothesis
- design/conduct experiment
- analyze data and draw conclusion
- restart process
what is a hypothesis?
a tentative statement
what is the requirement for a hypothesis?
must be falsifiable
Henry Molaison case study
as a boy, experienced mild seizures after falling off his bike and hitting his head
last resort → bilateral ablation (medical procedure to remove or otherwise destroy tissue) to ventral medial temporal lobes
- removed hippocampus
seizures stopped, but he couldn’t form new memories
what are the 2 divisons of the nervous system
- central nervous system
- peripheral nervous system
what are the cells of the NS
neurons, glial cells
what does the NS do
receive info from the external world and analyze/organize/interpret the information in a meaningful way
send messages to muscles so that they can produce behaviours
what do neurons do?
basic unit of communication that is an electrochemical process
what is action potential
electrical impulse that travels down the neuron and leads to the release of neurotransmitters
what are neurotransmitters
chemicals that carry messages to other neurons
soma
nucleus/DNA inside soma
manufactures everything the neuron needs to survive
dendrites
increase surface area of soma without taking up space
antennas of neuron, receives messages from other neurons
axon
where action potential travels down until it reaches terminal buttons
axon branches/terminals
little knobs at the ends of axon branches that contain the neural transmitters
terminal buttons
action potential release neural signals when they reach the terminal buttons
myelin sheath
white, fatty-like substance that provides insulation to axon
allows information to transmit very fast
do all axons have myelin sheath?
NO
synpase
place where neurons meet to communicate
synaptic cleft/gap
space between 2 neurons at the synapse
presynaptic vs postsynaptic neuron
presynaptic sends out messages
postsynaptic receives messages
what are the glial cells to neurons
NANNIES of neurons
help with development, nutrition, insulation, protection, cleaning
what is the function of glial cells
involved in higher mental functioning -> learning, memory, intelligence
linked with brain diseases
ions in a neuron at rest?
- negatively charged INSIDE (-70mV)
- positively charged OUTSIDE
- membrane is polarized
inhibitory messages
instruct neuron not to fire
how do inhibitory neurons change the concentration of ions
from -70 –> -77mV
HYPERPOLARIZED
excitatory neurons
instruct neuron to fire
how to excitatory neurons change the concentration of ions
from -70 –> -63 mV
DEPOLARIZED
when do neurons fire their signal
about -50mV
nodes of ranvier
gaps in the myelin sheath
what are nodes of ranvier for
channels so that ions can get in/out of the neuron
what happens chemically when neurons receive inhibitory messages
Cl- channels open and ions move INSIDE the neuron (influx)
inside of neuron is more negative (HYPERPOLARIZED(
what happens chemically when a neuron receives excitatory messages?
Na+ channels open and ions move INSIDE neuron (influx)
increases positive charge in neuron
if it charge reaches -50mV(threshold of excitation) neuron will fire
what happens after Na+ channels open in order to go back to its resting potential?
K+ channels open and ions leave neuron (efflux)
neuron reaches -70mV again
refractory period
period where neuron will not fire again if stimulated due to hyperpolarization
more negative than -70 due to K+ ions moving out of neuron
where does a neurotransmitter attach
to receptor sites
reuptake
neurotransmitters go back to the neuron that released it and is recycled for future use
degradation of neurotransmitters
enzyme breaks it down
why must a neurotransmitter be deavtivated
it will deliver the same message over and over again
overexcited the neurotransmitter
what are abnormal levels of dopamine linked to
shizophrenia
where do drugs produce their levels at
synapse
agonists (drugs)
enhance activity of neurotransmitters
can mimic a neurotransmitter and will deliver the same message
antagonists (drugs)
decrease/block activity of a neurotransmitter
competitive –> direct (drugs)
directly compete with neurotransmitters for parking spot
non-competitive –> indirect (drugs)
will not compete for same parking spot, will find another spot to attach to
enhances, reduces, or blocks activity of neurotransmitter
brainstem
connects brain to spinal cord
–> started where spinal cord ends
LIFE CENTER –> contains structures that control vital functions essential for survival (medulla, pons, RAS)
how is the brainstem a crossover point
info coming from LEFT will cross to RIGHT and vice versa
pons functions
connect CNS to PNS
regulate basic functions we don’t consciously think about
regulate arousal, coordinate senses, control facial expressions
what is RAS
network of neurons
where is RAS located
center of medulla and pons
RAS functions
bridges functions of body and brain via connections to spinal cord and thalamus
regulate levels of arousal and focus
to what disorder is RAS linked to
ADHD
cerebellum
controls voluntary movement, balance and muscle tone
–> involved in motor movements that become automatic
what amount of the brain does the cerebellum take up
1/10
what is the cerebellum linked to
learning, memory, creativity, reasoning, language
autism
getting “drunk”
thalamus
relay station –> all senses except smell send info to thalamus which then releases it to other areas of the brain
filters information and highlights what is important
what is the thalamus linked to
goosebumps
limbic system
contains hippocampus and amygdala
linked to emotion, memory, learning, motivation
hippocampus
involved in the formation of new memories and maintenance of cognitive maps
what is the hippocampus vulnerable to
chronic stress
what part of the brain does alzheimer’s affect first
hippocampus
amygdala
associated with aggression and the experience of emotions, especially fear
also associated with perception of emotions and emotional memories