teratogens Flashcards

1
Q

Ace inhibitors

A

renal damage

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2
Q

alkylating agents

A

absence of digits

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3
Q

aminoglycosides

A

ototoxicity

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4
Q

antiepileptic drugs

A

NTD

cardiac defects

cleft palate

skeletal abnormalities

recommended high dose folate

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5
Q

diethylstilbestrol

A

vaginal clear cell carcinoma

congenital mullerian anomalies

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6
Q

folate antagonists

A

NTD

trimethoprim, methotrexate, antiepileptics

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7
Q

isotretinoin

A

vitamin a

severe birth defects

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8
Q

lithium

A

ebsteins anomaly

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9
Q

methimazole

A

aplasia cutis congenita

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10
Q

tetracyclines

A

discolored teeth

inhibited bone growth

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11
Q

thalidomide

A

limb defects

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12
Q

warfarin

A

bone deformities

fetal hemorrhages

abortion

ophthalmologic abnormalities

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13
Q

alcohol

A

FAS

intellectual disability

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14
Q

cocaine

A

low birth weight

preterm labor

IUGR

placental abruption

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15
Q

smoking

A

low birth weight

preterm labor

placental problems

IUGR

SIDS

impaired oxygen delivery due to CO

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16
Q

iodine

A

congenital goiter or hypothyroidism

17
Q

maternal diabetes

A

caudal regression syndrome

congenital heart defects

NTD

macrosomia

neonatal hypoglycemia

18
Q

methymercury

A

neurotoxicity

swordfish, shark, tilefish, king mackerel

19
Q

vitamin A excess

A

spontaneous abortion

birth defects: heart, cleft palate

20
Q

x rays

A

microcephaly

intellectual disability