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Step Drugs > Teratogens > Flashcards

Teratogens Flashcards

1
Q

What effect do ACE inhibitors have on the fetus?

A

renal damage

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2
Q

What effect do alkylating agents have on the fetus?

A

absence of digits

multiple anomalies

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3
Q

What effect do aminoglycosides have on the fetus?

A

CN 8 tox

“A mean guy hit the baby in the ear”

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4
Q

What effect does carbamazepine have on the fetus?

A 
neural tube defects
craniofacial defects
fingernail hypoplasia
devel. delay
IUGR
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5
Q

What effect does DES have on the fetus?

A

vaginal clear cell carcinoma

congenital Mullerian anomalies

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6
Q

What effect do folate antagonists have on the fetus?

A

neural tube defects

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7
Q

What effect does lithium have on the fetus?

A

Ebstein anomaly (atrialized R ventricle)

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8
Q

What effect does methimazole have on the fetus?

A

aplasia cutis congentia

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9
Q

What effect does phenytoin have on the fetus?

A

fetal hydantoin syndrome = microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, intellectual disability

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10
Q

What effect do tetracyclines have on the fetus?

A

discolored teeth

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11
Q

What effect does thalidomide have on the fetus?

A

limb defects (phocomelia, micromelia- flipper limbs)

“limb defects with tha-LIMB-domide”

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12
Q

What effect does Valproate have on the fetus?

A

inhibition of maternal folate abs –> neural tube defects

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13
Q

What effect does Warfarin have on the fetus?

A

bone deformities
fetal hemorrhage
abortion
opthalamo abnormalities

“Do not wage WARFARe on the baby- keep it HAPpy with HEParin”

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14
Q

What drug causes renal damage to the fetus?

A

ACE inhibitors

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15
Q

What drug causes absence of digits and multiple anomalies to the fetus?

A

alkylating agents

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16
Q

What drug causes neural tube defects, craniofacial defects, fingernail hypoplasia, devel. delay, IUGR to the fetus?

A

carbamazepine

17
Q

What drug causes CN 8 tox to the fetus?

A

aminoglycosides

18
Q

What drug causes vaginal clear cell carcinoma

and congenital Mullerian anomalies to the fetus?

A

DES

19
Q

What drug causes neural tube defects to the fetus?

A

folate antagonists

20
Q

What drug causes Ebstein anomaly (atrialized R ventricle)to the fetus?

A

lithium

21
Q

What drug causes aplasia cutis congentia to the fetus?

A

methimazole

22
Q

What drug causes fetal hydantoin syndrome (microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, intellectual disability) to the fetus?

A

phenytoin

23
Q

What drug causes discolored teeth to the fetus?

A

tetracyclines

24
Q

What drug causes limb defects (phocomelia, micromelia- flipper limbs) to the fetus?

A

thalidomide

25
Q

What drug inhibits maternal folate abs –> neural tube defects?

A

valproate

26
Q

What drug causes bone deformities, fetal hemorrhage, abortion, opthalamo abnormalities to the fetus?

A

warfarin

27
Q

What drug causes intellectual disability, devel. retardation, microcephaly, holoprosencephaly, facial abnormalities (smooth philtrum, thin upper lip, small palpebral fissures, hypertelorism), limb dislocations, and heart defects to the fetus?

A

alcohol (fetal alcohol syndrome)

28
Q

What drug causes abnormal fetal growth, fetal addiction, and placental abruption?

A

cocaine

29
Q

What drug causes low birth weight, ADHD, IUGR to the fetus?

A

nicotine/CO from smoking

30
Q

What drug causes cleft palate and cardiac abnormalities to the fetus?

A

vitamin A excess

31
Q

What does alcohol do to the fetus?

A

fetal alcohol syndrome: intellectual disability, devel. retardation, microcephaly, holoprosencephaly, facial abnormalities (smooth philtrum, thin upper lip, small palpebral fissures, hypertelorism), limb dislocations, and heart defects

32
Q

What does cocaine do to a fetus?

A

causes abnormal fetal growth, fetal addiction, and placental abruption

33
Q

What does vitamin A excess do to a fetus?

A

causes cleft palate and cardiac abnormalities

34
Q

What does smoking do to a fetus?

A

causes low birth weight, ADHD, IUGR

35
Q

What do xrays do to a fetus?

A

cause microcephaly, intellectual disability

Step Drugs (3 decks)

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