Teratogens

Question 1

What effect do ACE inhibitors have on the fetus?

Answer 1

renal damage

Question 2

What effect do alkylating agents have on the fetus?

Answer 2

absence of digits

multiple anomalies

Question 3

What effect do aminoglycosides have on the fetus?

Answer 3

CN 8 tox

“A mean guy hit the baby in the ear”

Question 4

What effect does carbamazepine have on the fetus?

Answer 4

neural tube defects
craniofacial defects
fingernail hypoplasia
devel. delay
IUGR

Question 5

What effect does DES have on the fetus?

Answer 5

vaginal clear cell carcinoma

congenital Mullerian anomalies

Question 6

What effect do folate antagonists have on the fetus?

Answer 6

neural tube defects

Question 7

What effect does lithium have on the fetus?

Answer 7

Ebstein anomaly (atrialized R ventricle)

Question 8

What effect does methimazole have on the fetus?

Answer 8

aplasia cutis congentia

Question 9

What effect does phenytoin have on the fetus?

Answer 9

fetal hydantoin syndrome = microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, intellectual disability

Question 10

What effect do tetracyclines have on the fetus?

Answer 10

discolored teeth

Question 11

What effect does thalidomide have on the fetus?

Answer 11

limb defects (phocomelia, micromelia- flipper limbs)

“limb defects with tha-LIMB-domide”

Question 12

What effect does Valproate have on the fetus?

Answer 12

inhibition of maternal folate abs –> neural tube defects

Question 13

What effect does Warfarin have on the fetus?

Answer 13

bone deformities
fetal hemorrhage
abortion
opthalamo abnormalities

“Do not wage WARFARe on the baby- keep it HAPpy with HEParin”

Question 14

What drug causes renal damage to the fetus?

Answer 14

ACE inhibitors

Question 15

What drug causes absence of digits and multiple anomalies to the fetus?

Answer 15

alkylating agents

Question 16

What drug causes neural tube defects, craniofacial defects, fingernail hypoplasia, devel. delay, IUGR to the fetus?

Answer 16

carbamazepine

Question 17

What drug causes CN 8 tox to the fetus?

Answer 17

aminoglycosides

Question 18

What drug causes vaginal clear cell carcinoma

and congenital Mullerian anomalies to the fetus?

Answer 18

DES

Question 19

What drug causes neural tube defects to the fetus?

Answer 19

folate antagonists

Question 20

What drug causes Ebstein anomaly (atrialized R ventricle)to the fetus?

Answer 20

lithium

Question 21

What drug causes aplasia cutis congentia to the fetus?

Answer 21

methimazole

Question 22

What drug causes fetal hydantoin syndrome (microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, intellectual disability) to the fetus?

Answer 22

phenytoin

Question 23

What drug causes discolored teeth to the fetus?

Answer 23

tetracyclines

Question 24

What drug causes limb defects (phocomelia, micromelia- flipper limbs) to the fetus?

Answer 24

thalidomide

Question 25

What drug inhibits maternal folate abs --> neural tube defects?

Answer 25

valproate

Question 26

What drug causes bone deformities, fetal hemorrhage, abortion, opthalamo abnormalities to the fetus?

Answer 26

warfarin

Question 27

What drug causes intellectual disability, devel. retardation, microcephaly, holoprosencephaly, facial abnormalities (smooth philtrum, thin upper lip, small palpebral fissures, hypertelorism), limb dislocations, and heart defects to the fetus?

Answer 27

alcohol (fetal alcohol syndrome)

Question 28

What drug causes abnormal fetal growth, fetal addiction, and placental abruption?

Answer 28

cocaine

Question 29

What drug causes low birth weight, ADHD, IUGR to the fetus?

Answer 29

nicotine/CO from smoking

Question 30

What drug causes cleft palate and cardiac abnormalities to the fetus?

Answer 30

vitamin A excess

Question 31

What does alcohol do to the fetus?

Answer 31

fetal alcohol syndrome: intellectual disability, devel. retardation, microcephaly, holoprosencephaly, facial abnormalities (smooth philtrum, thin upper lip, small palpebral fissures, hypertelorism), limb dislocations, and heart defects

Question 32

What does cocaine do to a fetus?

Answer 32

causes abnormal fetal growth, fetal addiction, and placental abruption

Question 33

What does vitamin A excess do to a fetus?

Answer 33

causes cleft palate and cardiac abnormalities

Question 34

What does smoking do to a fetus?

Answer 34

causes low birth weight, ADHD, IUGR

Question 35

What do xrays do to a fetus?

Answer 35

cause microcephaly, intellectual disability