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Repro R&M > Teratogens > Flashcards

Teratogens Flashcards

p554

1
Q

ACE inhibitors

A

Renal damage

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2
Q

Alkylating agents

A

Missing digits, multiple other probs

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3
Q

Aminoglycosides

A

CN 8 tox

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4
Q

Carbamazepine

A 
Neural tube defects
Craniofacial defects
Fingernail hypoplasia
Developmental delay
IUGR
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5
Q

DES

A

Vaginal clear cell adenoCA

Congenital mullerian anomalies

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6
Q

Folate antagonists

A

Neural tube defects

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7
Q

Lithium

A

Ebstein anomaly (atrialized RV)

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8
Q

Methimazole

A

Aplasia cutis congenita

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9
Q

Phenytoin

A

Fetal hydantoin syndrome:

  • microcephaly
  • dysmorphic craniofacial features
  • hypoplastic nails and distal phalanges
  • cardiac defects
  • IUGR
  • ID
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10
Q

Tetracyclines

A

Discolored teeth

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11
Q

Thalidomide

A

Limb defects (phocomelia, micromelia)

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12
Q

Valproate

A

Neural tube defects (inhibits maternal folate absorption)

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13
Q

Warfarin

A

Bone defects
Fetal hemorrhage
Abortion
Ophthalmologic abnormalities

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14
Q

EtOH

A

Fetal alcohol syndrome:

  • ID
  • Developmental retardation
  • Microcephaly
  • Holoprosencephaly
  • Limb dislocation
  • Heart defects
  • Face probz: smooth philtrum, thin upper lip, small palpebral fissure, hypotelorism
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15
Q

Cocaine

A

Abnormal fetal growth
Baby coke addict
Placental abruption

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16
Q

Smoking

A 
Low birth wt
Preterm labor
Placental probs
IUGR
ADHD
17
Q

Iodine

A

Cretinism

18
Q

Maternal DM

A

Caudal regression syndrome: anal atresia-sirenomelia
Congenital heart defects
Neural tube defects

19
Q

Excess vitamin A

A

SAb
Cleft palate
Cardiac abnormalities

20
Q

X-rays

A

Microcephaly

ID

Repro R&M (7 decks)

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