Teratogens

Question 1

ACE inhibitors

Answer 1

Renal damage

Question 2

Alkylating agents

Answer 2

Missing digits, multiple other probs

Question 3

Aminoglycosides

Answer 3

CN 8 tox

Question 4

Carbamazepine

Answer 4

Neural tube defects
Craniofacial defects
Fingernail hypoplasia
Developmental delay
IUGR

Question 5

DES

Answer 5

Vaginal clear cell adenoCA

Congenital mullerian anomalies

Question 6

Folate antagonists

Answer 6

Neural tube defects

Question 7

Lithium

Answer 7

Ebstein anomaly (atrialized RV)

Question 8

Methimazole

Answer 8

Aplasia cutis congenita

Question 9

Phenytoin

Answer 9

Fetal hydantoin syndrome:

• microcephaly
• dysmorphic craniofacial features
• hypoplastic nails and distal phalanges
• cardiac defects
• IUGR
• ID

Question 10

Tetracyclines

Answer 10

Discolored teeth

Question 11

Thalidomide

Answer 11

Limb defects (phocomelia, micromelia)

Question 12

Valproate

Answer 12

Neural tube defects (inhibits maternal folate absorption)

Question 13

Warfarin

Answer 13

Bone defects
Fetal hemorrhage
Abortion
Ophthalmologic abnormalities

Question 14

EtOH

Answer 14

Fetal alcohol syndrome:

• ID
• Developmental retardation
• Microcephaly
• Holoprosencephaly
• Limb dislocation
• Heart defects
• Face probz: smooth philtrum, thin upper lip, small palpebral fissure, hypotelorism

Question 15

Cocaine

Answer 15

Abnormal fetal growth
Baby coke addict
Placental abruption

Question 16

Smoking

Answer 16

Low birth wt
Preterm labor
Placental probs
IUGR
ADHD

Question 17

Iodine

Answer 17

Cretinism

Question 18

Maternal DM

Answer 18

Caudal regression syndrome: anal atresia-sirenomelia
Congenital heart defects
Neural tube defects

Question 19

Excess vitamin A

Answer 19

SAb
Cleft palate
Cardiac abnormalities

Question 20

X-rays

Answer 20

Microcephaly

ID