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Reproductive > Teratogens > Flashcards

Teratogens Flashcards

1
Q

Lamotrigene

A

Folate antagonism

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2
Q

Cholestyteramine

A

depletion of B12, DHFR co factor

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3
Q

Valproic Acid

A

folate antimetabolite

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4
Q

Bosentan

Isotretinoin

A

interference w/ neural crest migration, RA and RX receptors

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5
Q

DES

A

androgen/estrogen balance

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6
Q

Thalidomide

A

ROS generated by fetal metabolism (PG synthetases, lipooxygenases)

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7
Q

Misoprostol, ergotamine

A

placental obstruction, spasm

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8
Q

ACEs, ARBs

A

renal bloodflow & development

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9
Q

Statins

A

Cholesterol depletion (membranes and signals)

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10
Q

NSAIDS

A

COX inhibition

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11
Q

Sumatriptan, fluoxetine

A

serotonin receptors, transporters

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Reproductive (6 decks)

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